#80

A lot of men get prostate cancer, much fewer die from it. However, that does not mean it is not an issue.

The prostate is interesting to me particularly because of its function of providing citrate for the fertilized egg (in seminal fluid).

It seems quite clear that there is a link between low levels of acetyl-CoA in prostate cells and aberrant splicing causing an enlarged prostate and then prostate cancer.

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#81

A new thought for me: How do you propose one could deal with low levels of acetyl-CoA specifically in prostate cells?

#82

If you want to live to the normal age of 77 for men, prostate cancer probably won’t kill you.

If you want to live longer than 100, prostate cancer has a good chance to kill you before that.

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#83

Its the usual mixture of things really. I do weekly blood tests, but don’t always have the PSA measured. From time to time I increase and reduce my citrate supplementation (remember it is relatively high even when it is to me low) and the PSA seems to go even lower when citrate supplementation is high.

These are the recent values in micrograms per litre:

0.77 0.78 0.85 0.92 0.75 0.73

The 0.92 figure coincided with a reduction in citrate supplementation.

Melatonin probably also helps in terms of resisting mitochondrial heteroplasmy.

About a year ago I had these values: 1.1 1.34 1.18

The last of those is 21 June 2023.

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#84

@John_Hemming Which citrate types do you find are useful in reducing your PSA?

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#85

The issue with citrate is the balance between the cations. When you increase the amounts of citrate you have to increase the cations. The cations I use are Sodium, Potassium, Magnesium and Calcium.

When you go for really high levels of citrate that will cause pressure on the kidneys. “Really high” is unclear I don’t think 10g is really high. Really high is probably 40 or more, but I don’t know and this will vary by individual.

Hence it is really important to monitor kidney function.

Best look at my protocol function to see the various ratios etc.

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#86

Ejaculation Frequency and Risk of Prostate Cancer: Updated Results with an Additional Decade of Follow-up: Men with ≥21 ejaculations per month were less likely to be subsequently diagnosed with prostate cancer

https://www.sciencedirect.com/science/article/abs/pii/S0302283816003778

Seems to dove-tail well with this research:

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#87

So, this would add some daily “routines” for those, taking care about their health… :slight_smile:

Would also take our discussion about possible effect of ezetimibe on BPH to this thread (for those, reading specifially this thread):

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#88

This is a bit funny and strange at the same time. What percentage of men over the age of say 30 achieve those numbers? I’d guess a very small %. Doesn’t seem like a credible stat.

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#89

Hahaha… very doable at 66 years.
Could be the TRT and Rapamycin combo. :stuck_out_tongue::wink:

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#90

You would be surprised how many can attain that level. If you’re falling behind on those numbers with your partner, you can always give yourself a hand. :wink:

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#91

Amid a global surge in prostate cancer cases, new tests are helping prevent overdiagnosis and catching the most severe cases in time to treat them.

We are finally improving prostate cancer diagnoses - here’s how

However, while the increase in cases is a foregone conclusion – a reflection of our ageing population – the increase in deaths isn’t. That is because, in recent years, we have begun to see a transformation in our diagnostic tools. These are helping doctors to identify the most severe prostate cancers earlier and more accurately than ever before, helping people like me make more informed choices about our options and increasing the likelihood that we won’t die of the condition. So, what exactly has happened, and what tests – if any – should I be signing up for?

Read the full article: We are finally improving prostate cancer diagnoses - here’s how (New Scientist)

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#92
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#93
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#94

Seems the open issue is the quality of that life post surgery…

The survival rate of men with prostate cancer who had their entire prostate gland removed immediately after the tumor was detected increased by 17 percentage points compared with those who did not have treatment until the tumor began to cause symptoms. On average, they also lived more than two years longer.

These are the final results of a 30-year Scandinavian study led by Uppsala University and published in the New England Journal of Medicine .

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#95

Have any cyclists here looked into the risk of prostate cancer and number of hours spent in the bike saddle (and what type of bike seat is best for this)?

Cycling and prostate health have been linked for several years, particularly in the wake of a 2014 study that discovered a direct relationship between the amount of riding time per week and the risk of a prostate cancer diagnosis.

He told the Sunday Times that he had been diagnosed with primary cancer in his prostate, which had spread to his bones - meaning it was stage four.

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#96

Like I said in another post, my first PSA test was my only alarming test, at 7.49, and it threw both me and my doctor into a panic. I was devastated and contemplating what to do in the most dire scenario. But first, the test had to be redone, which was in another week or so, and it came back just under 1. Thinking back on that first test, I realized that the day before I did a 5 hour bike ride along the coast. I mentioned that to my doc, who said “yep, that could account for it”. I have never since (almost 20 years) had anything above 1.1.

Pro tip: I was also alerted to the fact that many men get inaccurate PSA readings, because in the office they get the digital exam (finger-in-bum), and then go straight to the lab. There, the prostate which has been perturbed/bruised by that digital examination, will give you an elevated PSA reading, giving you sleepless nights and grim thoughts. So, shortly before you get a PSA test, make sure you have not stressed your prostate excessively, by bike rides, digital exams, even holding in your urine for too long (f.ex. in a movie theater). Also, no sex, or ejaculate 3 days before the PSA blood draw.

Pro tip 2: In the opposite direction. Please be aware, that some of the drugs and supplements you take, will bring down your PSA reading, like statins - but as a PC researcher (I think I heard it on one of Attia’s interviews), explained, that is a falsely low artificially suppresed reading not reflecting the true health of the prostate. So you have to take a correction on that reading - that 0.9 might be a 1.00 etc. depending on the drug or supplement. Why does that matter? Because as one of my favorite studies showed - a study I linked elswhere - Swedish scientists determined that a single reading at age 60 tells you if you might get PC, with very high probability. If your PSA reading at 60 yo, is at or below 1, the odds that you will die of PC by age 85 is extremely remote. And so, if you get a reading of 1 by age 60, if you are taking a drug that suppresses the PSA marker - the true reading is in fact 1.1, and you are suddenly not “in the clear” anymore. That’s why even small values this way or that can matter.

Bottom line, PSA is a valuable tool, but a tricky one to handle. And watch those bike rides.

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#97

Lepper makes a special seat that places no pressure on the family jewels. I have one if anyone wants it. I did not find it comfortable.

#98

My Urologist recommends the ISM seats. The lack of a nose feels a little unsafe to me, but my friend loves his.

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#99
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