FDA-Approved Drug Combo Rescues Alzheimer’s in Mice

Elizabeth_Kirby · 2025-07-23T12:14:13.590Z

scientists from the University of California San Francisco set out to find existing drugs that would be effective against Alzheimer’s disease.
The immunosuppressant rapamycin (sirolimus), known for its anti-aging properties, also made the cut

lifespan.io

FDA-Approved Drug Combo Rescues Alzheimer’s in Mice

Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s [1]. […]

adssx · 2025-07-23T19:35:17.345Z

Thanks. The paper: Cell-type-directed network-correcting combination therapy for Alzheimer’s disease 2025

AgentSmith · 2025-07-23T20:00:04.705Z

Interesting given that the forum has been very pro-estrogen and letrozole is a powerful aromatase inhibitor.

cl-user · 2025-07-23T20:47:52.516Z

It’s interesting to see that one of the other identified compounds is an antifungal agent (ciclopirox) but we know that rapamycin is also an antifungal agent and that fungi (Candida, etc.) is found in Alzheimer’s brains.