I don’t know if this is hype, but I will investigate it. I am always looking for ways to reduce my stack or the number of pills/capsules that I take.
I am glad you pointed out Nacet vs Nac. I don’t know how I missed this. I am going to switch.
"NACET Supplement vs NAC Supplement
Pharmacokinetics and Bioavailability
NACET
Rapidly absorbed and enters cells more effectively than NAC ([2])
Higher oral bioavailability compared to NAC ([5])
Lipophilic nature allows easier crossing of cell membranes ([6])
NAC
Less effective cell penetration compared to NACET ([2])
Lower oral bioavailability compared to NACET ([5])
Antioxidant Properties
NACET
More efficient in increasing cell viability under oxidative stress ([1])
More effective in increasing intracellular reduced glutathione (GSH) levels ([1], [6])
Significantly increased glutathione content in various tissues, including the brain ([2])
NAC
Less efficient in increasing intracellular GSH levels compared to NACET ([6])
Showed benefits when combined with glycine (GlyNAC) in older adults ([3])
Efficacy in Specific Applications
NACET
Provided better protection against paracetamol intoxication in rats ([2])
Increased GSH levels in rats’ eyes after oral administration ([1])
NAC
No significant improvement in sport performance (mean increase 0.29%, 95% CI -0.67 to 1.25) ([4])
Risk of side effects not significantly different from placebo in sports performance studies ([4])
Potential Limitations
NACET
High concentrations may inhibit GSH synthesis ([6])
Conclusion
Based on the available research, NACET appears to have several advantages over NAC as a supplement. NACET demonstrates superior pharmacokinetics, including higher oral bioavailability and better cell penetration. It also shows more efficient antioxidant properties, particularly in increasing intracellular glutathione levels. However, it’s important to note that most of these studies were conducted in vitro or in animal models, and more human clinical trials are needed to confirm these benefits.
While NAC has been more extensively studied in human subjects, including its combination with glycine for older adults, it generally shows less efficacy compared to NACET in direct comparisons. The lack of significant benefits in sports performance for NAC also suggests limitations in its application.
It’s worth noting that high concentrations of NACET may inhibit GSH synthesis, indicating a potential need for careful dosing. Future research should focus on optimal dosing strategies for NACET and more extensive human trials to fully understand its benefits and potential side effects compared to NAC"
“Superior Properties of N-Acetylcysteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage - PMC
N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential - PubMed”
8 Likes
Interesting. What is the difference referred to here for absorption? 60% vs 70%?
I don’t know it’s just some supplement maker’s claims.
2 Likes
LaraPo
#304
What’s a good brand for NACET?
1 Like
Or just any brand anyone ever heard of…? I just did a search and came up empty on known brands.
1 Like
ng0rge
#306
See my post here: ( Lipmaxmall NACET - on Amazon)
https://mmabrasil.localizer.co/t/use-of-carnosine-as-a-natural-anti-senescence-drug-for-human-beings/5761/54?u=ng0rge
Also used by @Ericross2 , but again quality is unproven…I’ve been using it and it smells a little of sulfur, as it should, but no proof of purity or COA. No noticeable effects, I take it with glycine.
2 Likes
I never heard of this brand. If you guys survive, be sure to tell us if you got any benefits. I was amazed at the single digit absorption of NAC so I’m very interested. Thanks!
2 Likes
LaraPo
#308
Don’t know if it’s a good brand.
https://a.co/d/0awd6NIM
1 Like
Thanks. I never heard of them. The “analysis” documentation was from 2 years ago. I hope someone will volunteer to be the test pilot.
1 Like
ng0rge
#310
Their website looks good - Nature’s Fusions - and they’re in Utah! The bottom COA from Summit is 12/23 so I’d say they look better than Lipmaxmall. Again hard to be sure with these unknown companies…we need a ConsumerLab test.
https://www.naturesfusions.com/support/why-natures-fusions/#/
1 Like
FWIW: I ordered a bottle of this unknown brand because it was on sale to give it a try.
The reviews look pretty good but who knows?
It is the brand that the tables came from.
https://www.amazon.com/N-Acetyl-Cysteine-Ethyl-Ester-100mg/dp/B0B79Z6P29/
1 Like
I’ve taken NACET before. It is 10X more absorbable but it has only 10% of the NAC. So it’s a wash. It appears to be just as effective as NAC. It’s more expensive though.
2 Likes
They claim it crosses the BBB, regular NAC doesn’t.
They claim it causes more glutathione synthesis than NAC.
I don’t know if this is true, I am still investigating their claims.
2 Likes
I can’t comment on either of those. How exactly would you measure that? I’m not willing to do a brain biopsy. 
I’ll give it the benefit of the doubt in that I value it as equal to regular NAC. They need some kind of marketing gimmick to justify the more expensive price.
From my father’s experience, regular old NAC raises glutathione just fine, so I’m just going to stick with that.
1 Like
How will you assess its effectiveness? GGT is a marker of low glutathione / low antioxidant status
2 Likes
LukeMV
#317
I bought and have been using this brand for a few weeks. I don’t notice any subjective difference but I never really do with supplements in general. I’m also 38 years old so I might not notice what someone older than me would notice.
https://a.co/d/0dhE9cxO
2 Likes
NAC has a history of being researched as a medication for mental disorders. Bipolar-mania states, Schizophrenia, depression etc .
I find it unlikely that regular NAC or its metabolites don’t cross the BBB.
1 Like
I tended to have mild OCD in the past. NAC stopped that cold.
Since then, I have learned that OCD really helped me at my job. 
4 Likes
Beth
#320
I get that!!! I have untreated ADD, and while it’s annoying, I believe it inexplicably contributed to my success at work… in addition to making some parts harder. Don’t ask how, I don’t know!
1 Like
