I take 400mg GGC (Gamma-Glutamyl-Cysteine), an even more effective Glutathione precursor than Glycine+NAC, 2-3 times a day and it completely eliminated the brain-fog I had developed 2 years previously after an episode of TGA (Transient Global Amnesia, sometimes referred to as sleep-walking), and my brain-fog comes back anytime I forget to take GGC for more than 12 hours. I often wake up in the early hours of the morning with a slight headache (a precursor of my brain-fog) and taking GGC gets rid of it in 30 minutes and I fall back asleep.
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LukeMV
#289
Is this over the counter? Donât see it on amazon or any product links when I googled it
Please try this - https://www.glyteine.com/
Available through Amazon. Cheers
1 Like
LukeMV
#291
Thank you! So this is even better than NACET?
Yes, GGC (brand name glyteine) is 100% absorbed by cells in the body and then converted to Gluthathione. Hence 400mg every 12 hours is typically enough, even at an advanced age, unlike with NAC where you need to keep upping your dosage up to 9g/day and even then it is never clear if the tiny fraction your cells are able to convert to Gluthathione is enough. The rate limiting enzyme that produces GGC from Cysteine (derived from NAC) keeps decreasing with age.
Only one company (from Australia) sells it and they spent 20 years trying to synthesize GGC at reasonable cost and finally gave up and ended up extracting the rate limiting enzyme from freshly slaughtered beef kidney and reacting it with gluthathione + Cysteine : It is why their manufacturing plant is located in a Texas slaughterhouse district.
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LukeMV
#293
I ended up doing research and finding them. Man that is an expensive supplement though. Might just stick with NACET
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Whatâs the rationale for ongoing glutathione boosting with exogenous chemicals? Can a person work toward not depleting their own glutathione production? Reducing oxidative stress, mitochondrial health, etc.?
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tananth
#295
The current theory is that the GGC rate limiting enzyme inevitably declines with age, and I have not found any studies suggesting there is any way to avoid this. I wonder if John Hemmings Citrate therapy could rescue the production of this complicated enzyme, but so far the best you can do is measure your own rate of Glutathione production with a blood test for intra-cellular Glutathione. Other than cost, there seems to be no downside to excessive Gluthathione supplementation, since GGC circulates in blood for 3-4 hours and cells dump excess Gluthathione (from conversion of GGC) back into the blood stream on its way to the liver to be broken down into 3 amino acids. The exception might be if you are being treated for cancer, since Gluthathione may protect cancer cells (as well as healthy cells) from Chemotherapy drugs : Oncologists routinely counsel discontinuing all anti-oxidant supplements (other than Vitamin C).
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LukeMV
#297
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The paper you cited (https://www.sciencedirect.com/science/article/abs/pii/S0891584918311055) seems to say that even though NACET is more effective than NAC at boosting Gluthathione in vitro (cell culture studies) neither NACET nor NAC is likely to be very effective at boosting Gluthathione in clinical studies.
Once the GGC producing rate limiting enzyme has dropped below critical levels (seems to happen inevitably in old age) even very large doses of NAC or NACET will not restore youthful levels of Gluthathione and GGC (brand name glyteine) becomes the only Gluthathione precursor that will work. Since GGC is very expensive, you could use blood tests for Gluthathione levels ($59 from Marek Health) to determine if NAC or NACET (+Glycine) are still effective and keep raising the dosage of NAC or NACET until the cost becomes comparable to GGC ($3/day) or the NAC/NACET dosage produces unpleasant side effects (rotten egg farts from breakdown of NAC into Hydrogen Sulfide in the gut)
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My father is 77 yo. He takes both Glycine and NAC. His blood work shows glutathione levels at 1000 which is very youthful even for someone in their 20s. Supplementing with Glycine and NAC works even in your late 70s.
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LukeMV
#300
We have human studies showing GlyNAC boosts glutathione though. Iâd expect NACET and glycine together to be even better.
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I donât know if this is hype, but I will investigate it. I am always looking for ways to reduce my stack or the number of pills/capsules that I take.
I am glad you pointed out Nacet vs Nac. I donât know how I missed this. I am going to switch.
"NACET Supplement vs NAC Supplement
Pharmacokinetics and Bioavailability
NACET
Rapidly absorbed and enters cells more effectively than NAC ([2])
Higher oral bioavailability compared to NAC ([5])
Lipophilic nature allows easier crossing of cell membranes ([6])
NAC
Less effective cell penetration compared to NACET ([2])
Lower oral bioavailability compared to NACET ([5])
Antioxidant Properties
NACET
More efficient in increasing cell viability under oxidative stress ([1])
More effective in increasing intracellular reduced glutathione (GSH) levels ([1], [6])
Significantly increased glutathione content in various tissues, including the brain ([2])
NAC
Less efficient in increasing intracellular GSH levels compared to NACET ([6])
Showed benefits when combined with glycine (GlyNAC) in older adults ([3])
Efficacy in Specific Applications
NACET
Provided better protection against paracetamol intoxication in rats ([2])
Increased GSH levels in ratsâ eyes after oral administration ([1])
NAC
No significant improvement in sport performance (mean increase 0.29%, 95% CI -0.67 to 1.25) ([4])
Risk of side effects not significantly different from placebo in sports performance studies ([4])
Potential Limitations
NACET
High concentrations may inhibit GSH synthesis ([6])
Conclusion
Based on the available research, NACET appears to have several advantages over NAC as a supplement. NACET demonstrates superior pharmacokinetics, including higher oral bioavailability and better cell penetration. It also shows more efficient antioxidant properties, particularly in increasing intracellular glutathione levels. However, itâs important to note that most of these studies were conducted in vitro or in animal models, and more human clinical trials are needed to confirm these benefits.
While NAC has been more extensively studied in human subjects, including its combination with glycine for older adults, it generally shows less efficacy compared to NACET in direct comparisons. The lack of significant benefits in sports performance for NAC also suggests limitations in its application.
Itâs worth noting that high concentrations of NACET may inhibit GSH synthesis, indicating a potential need for careful dosing. Future research should focus on optimal dosing strategies for NACET and more extensive human trials to fully understand its benefits and potential side effects compared to NAC"
âSuperior Properties of N-Acetylcysteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage - PMC
N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential - PubMedâ
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Interesting. What is the difference referred to here for absorption? 60% vs 70%?
I donât know itâs just some supplement makerâs claims.
2 Likes
LaraPo
#304
Whatâs a good brand for NACET?
1 Like
Or just any brand anyone ever heard of� I just did a search and came up empty on known brands.
1 Like
ng0rge
#306
See my post here: ( Lipmaxmall NACET - on Amazon)
https://mmabrasil.localizer.co/t/use-of-carnosine-as-a-natural-anti-senescence-drug-for-human-beings/5761/54?u=ng0rge
Also used by @Ericross2 , but again quality is unprovenâŚIâve been using it and it smells a little of sulfur, as it should, but no proof of purity or COA. No noticeable effects, I take it with glycine.
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I never heard of this brand. If you guys survive, be sure to tell us if you got any benefits. I was amazed at the single digit absorption of NAC so Iâm very interested. Thanks!
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