Growth Hormone and longevity

[Steve_Combi]

@LukeMV

It’s also important to remember that HGH rejuvenated the thymus in every “older” person that participated in the TRIIM trials.

Also without adequate hGH your tendons and ligaments don’t heal like they do in our youth. When combined with BPC 157 which is purported to be a hGH receptor agonist in tendons and ligaments, hGH can then be more effective in healing those tissues. IF you have any being produced at ones age, mine would be near zero at 69y/o.

As someone who suffered for years with nagging tendon issues, which have resolved over the past 18 months, I’m super happy to be basically pain free and with full range of motion restored.

Even the crunching in my neck that was there for 6 or 7 years is gone.

Quality of life is my goal. Not “longevity”

To be clear, I personally would not use Somatotropin. I’m more interested in having my systems do their job and produce hGH “naturally” at the right time in the circadian/hormonal cycle.

Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in...

[LukeMV]

I still say all that improved quality of life will lead to better longevity in the end

[Steve_Combi]

@Steve_Combi

IF you have any being produced at ones age, mine would be near zero at 69y/o.

Growth Hormone in Aging

[Neo]

@Steve_Combi

Neo, I’m happy that you are presenting the other side of this discussion so others can make an informed decision.

Sounds good - it’s just to me that this does not feel like one of those 50/50 cases

For anyone new to the topic - and to both @Steve_Combi and @LukeMV

See below how for geroscientists, human data, investors and at least for dog, the FDA suggest that lower IGF-1 or IGF-1 inhibition is pro longevity.

If your goals are short term health, muscle building, perhaps wound healing the answer might be difference. For longevity the data seems to line up more in one way than the other

Greg Fahy: We may have discussed what this guy is doing but can we talk more about him

Luke, all the research I’ve read (and there is a lot of it) is that higher Growth Hormone/IGF-1 levels translate into shorter lives. In fact a lot of effort and money (tens of millions of $ just into Loyal), is going into new drugs to lower IGF-1/GH as longevity drugs. Here are some threads and links on this: IGF-1 inhibitors and lifespan extension? and Here: Another (likely) Longevity Drug - Somavert / Pegvisomant GH supplementation was big in the world of “anti-aging medicine” and the A4M about 15 to 20 years ago… when people are much older and in worse shape than you (say in their 60s and 70s) it is reputed that GH can make people feel better, stronger, etc. But as more and more research came out around IGF-1 over the decades, it fell out of favor and became known as clearly pro-aging in the long term. But there are likely short term benefits - especially after injury, etc. Unless you’ve seen some research I’ve missed, I suspect the ideal dosing is going to be something that…

IGF-1 inhibitors and lifespan extension?

Is there any studies on any drug that inhibit IGF-1 and which has shown good lifespan extension?

Another (likely) Longevity Drug - Somavert / Pegvisomant

There has been a ton of research on the Growth Hormone / IGF-1 pathway by geroscientists over the past few decades. And, the Loyal for Dogs company is currently working through an FDA approval process for an IGF-1 inhibition drug that may be the first drug approved by the FDA to increase healthspan and lifespan (for dogs). I came across this paper today and read the following paragraph, that caught my eye: Inhibitors of the GH/IGF-1 axis Although the lack of global IGF-1 signaling is lethal, data from studies conducted in animal models have shown that a reduction in IGF-1 levels or IGF-1 action can extend lifespan. Additionally, human IGF-1 receptor gene polymorphisms are associated with exceptional longevity (Suh et al., 2008), and recently, Barzilai and colleagues have shown that low plasma IGF-1 concentrations predict survival in long-lived people (Milman et al., 2014), specifically in women with a history of cancer. In animals, dwarf, long-lived mice lacking the growth hormone …

IGF-1 is Lower for Centenarians

Here’s an interesting tidbit from Nir Barzilai’s centenarian study. Centenarians have lower IGF-1 levels than is typical. I believe rapamycin will drop IGF1 [NOT The Longevity Genes!? Surprising Facts WHY Centenarians LIVE LONGER | Dr Nir Barzilai Clips]

$125M to extend dog lifespan

Antiaging pill for dogs clears key FDA hurdle (WaPo)

[imrs.php] Dog owners do many things to keep their companions happy and healthy. They could soon add an antiaging pill to their pooch’s regimen of walks, vet visits and belly rubs. Loyal, a biotech start-up based in San Francisco, said Wednesday that a drug it developed to increase canine lifespan passed a significant milestone on the way to regulatory approval. The Food and Drug Administration certified the daily pill as having a “reasonable expectation of effectiveness” at extending senior dogs’ lifespans. The regulator’s Center for Veterinary Medicine still has to certify that the drug is safe and that Loyal can manufacture it at scale before vets can prescribe the pill to dogs 10 years or older who weigh 14 pounds or more. While the drug’s cost to consumers is yet to be determined, Halioua said in a Zoom interview that she wants to make Loyal’s treatment accessible to as many dogs as possible, ideally for under $100 per month. Read the full story: See Spot live longer: A…

[Neo]

@LukeMV

It’s also important to remember that HGH rejuvenated the thymus in every “older” person that participated in the TRIIM trials.

Again if you talk with Greg Fahy the developer of this protocol (I have many times), he will be the first to tell you:

• the befits are from the Thymus regeneration itself and the immune benefits

• having to use GH is in order to get that generation, not because they wanted for other reasons to increase people’s GH (perhaps even despite)

• given that they designed it so the growth hormone is only given during a very limited period of time, and with hope of not having to repeat more than a few times during one’s entire life

so for the VAST majority of the time, their patients DO NOT supplement with GH

[Steve_Combi]

@Neo

their patients DO NOT supplement with GH

And neither do I…

From the paper I provided above

GHRH and GHS stimulate the secretion of GH. Since most AGHD is caused by pituitary lesions, and these patients, unlike healthy seniors, are unresponsive to GHRH or GHS, there are few studies of treatment with these agents.

Theoretically, treatment with GHRH or GHS should lead to more physiologic GH replacement, leading to a pulsatile rather than prolonged elevation in GH and preserving the ability for negative feedback inhibition of GH by increasing IGF-I. GHRH and GHS effects are influenced by the same factors which modulate endogenous GHRH secretion, such as negative feedback by somatostatin. This normal negative feedback regulation would be expected to result in buffering against overdose. The side effects of GHRH treatment are similar in character to GH treatment but are milder and less frequent. Since the GHS are smaller molecules than GH, and generally resistant to digestive enzymes, they can be administered via the oral, transdermal or nasal routes.

[Steve_Combi]

@Neo

lower IGF-1 or IGF-1 inhibition is pro longevity.

From the paper I referenced.

Mechanistic insights into the role of growth hormone and IGF-I in age-related alterations in cognitive function were assessed in several studies by Sonntag and colleagues demonstrating somatotrophic effects on rodent brain aging (26). These studies suggest that deficiencies in GH and IGF-I contribute to the functional decline in senescent rats whereas augmentation of GH or IGF-I improved cognitive function, increased glucose utilization throughout the brain, increased cortical vascularity, and ameliorated age-related decline in hippocampal neurogenesis**.**

A 2006 study of the effects of 6-months daily treatment with sermorelin acetate, a GHRH analogue, on cognitive function of 89 elderly adults found significant improvement on several cognitive assessments, particularly those involving problem solving, psychomotor processing speed, and working memory, but no change on tests reflecting crystallized intelligence (27). Higher GH levels were associated with higher Wechsler Adult Intelligence Scale performance IQ scores, and greater increases in IGF-1 were associated with higher verbal fluency test scores, while gender, estrogen status, and initial cognitive function did not interact with the GHRH effect on cognition.

A 2013 pilot study of 30 elderly adults given a stabilized analogue of GHRH, tesamorelin, versus placebo, used magnetic resonance spectroscopy to examine the effects of inhibitory and excitatory neurotransmitters (60). After 20 weeks GABA levels were increased in all brain regions, N-acetylaspartylglutamate levels were increased in the dorsolateral frontal cortex, and myo-inositol (an osmolyte linked to Alzheimer disease) levels were decreased in the posterior cingulate, with similar results across adults with mild cognitive impairment (MCI) and those with normal cognitive function. Treatment related changes in serum IGF-1 were positively correlated with changes in GABA and negatively correlated with myo-inositol. There was a favorable treatment effect on cognition (p = .03), but no significant associations were observed between treatment-related changes in neurochemical and cognitive outcomes.