#1

After my first 20mg dose post 6 year break. Ive been focusing on raising MTOR instead and repair some of the damage ive done to this vessel. I got extremely surpriced how much energy and mental clarity i got from it. In my other post i posted a study on how it effect blood flow to the brain. Saw this on reddit and it makes alot of sense now

From bed bound with severe PEM to playing basketball in 6 weeks: a rapamycin success story : r/covidlonghaulers

Within that first week, I started to feel a feeling I hadn’t felt in a long time. Instead of my muscles feeling oxygen starved, I started to feel like the oxygen was returning and they had more energy. I was far too afraid to push anything too quickly, though, so I stayed in bed and continued to rest. The next week when I took the second dose, the same headache and inflammation returned, albeit at a fraction of the intensity, maybe 25%. The same thing happened the week after, and the week after that, until I no longer noticed any differences before and after taking the drug. During this time, something strange happened: multiple times, I accidentally overexerted myself and awaited the incoming PEM, but woke up the next day and felt totally fine. Intrigued, I continued to test my limits in week 3 and found that nothing I did was causing PEM. From that week onwards I really started pushing and worked up to shooting hoops by week 6. Once again, no PEM. At week 8 now, I exercise multiple times a day and have no problems with fatigue at all. I have some serious deconditioning from lack of activity over the past couple of years, but I haven’t had any PEM since starting rapamycin

Anyone use 20mg every 10 days or do you always wait 14 days?

This felt alot more then lets say 5g L citruline regarding blood flow. combining it with 5mg cialis must feel great

#2

Another study, so… senssent cells drain the oxygen supply. And rapa restore it

Consistent with our previous observations, the senescent cells exhibited a higher basal oxygen consumption rate, i.e., OxPhos, up to 6 pmol/min/105cells vs 1 pmol/min/105cells in early passage cells, and increased glycolysis 5.5 vs 1 mg/dl/105cells, along with associated medium acidification (Fig. 1). Long-term treatment of cells with rapamycin corrected all three processes back to the early passage cells.

Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts - PMC

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#3

More in the study above:

However, it appears that rapamycin both reduces the dependence on glycolysis and enhances the ability to utilize other respiratory metabolites. It appears that the metabolic rejuvenation of senescence cells through long-term treatment with a low (nM) dose of rapamycin may occur via reprogramming of pyruvate and glutamate oxidation, and possibly fatty acids

This is truly incredible. Im using other therapies that work on pyruvate, to increase energy n rejuvination, that rapa can reprogram the entire system to a younger age is very impressive

#4

Your original question was whether a one time large dose would hurt and the answer was no. If you do it every 10 days or 2 weeks you should test on the last day to make sure your trough is low enough to not get a buildup. I don’t know why but high doses really messed with my lipids and fasting glucose. I felt fine, but got paranoid about my numbers. Probably wrong, but something to watch. Side effects will start to limit.