I’ve had arrhythmia on and off through my life and it may have been activated by taking 4mg rapa.
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Hey Joe… hmmm… in dogs it repairs heart disease… particularly the left ventricle. Used to prevent organ rejection since 1970s.
To my knowledge more good than bad for heart… but arrhythmias is not impossible it seems.
Rapamycin and its potential benefits:
- Regressing Cardiac Hypertrophy:
Rapamycin can regress cardiac hypertrophy, particularly that caused by pressure overload.
- Improving Cardiac Function:
Studies have shown that rapamycin can improve cardiac function in aged mice and potentially in cases of cardiomyopathy related to LMNA mutations.
- Treating Cardiac Sarcoidosis:
Rapamycin, as a steroid-sparing agent, has shown promise in treating cardiac sarcoidosis, an inflammatory disease that can cause arrhythmias and cardiomyopathy.
- Slowing Transplant Vasculopathy:
Rapamycin has been shown to slow the progression of cardiac transplant vasculopathy.
Rapamycin and its potential risks:
Increased activity of mTOR, which is
- modulated by rapamycin, has been linked to remodeling of the [rapid delayed rectifier channel in the atria, potentially predisposing individuals to arrhythmias, including atrial fibrillation.
Arrhythmias as Chemotherapy Side Effect:
Rapamycin is sometimes used in cancer treatment and can be associated with chemotherapy-induced cardiotoxicity, including arrhythmias.
In summary: Rapamycin’s effects on the heart are complex. While it can be beneficial in treating certain conditions like cardiac hypertrophy and sarcoidosis, it may also be associated with the development of arrhythmias in some cases.
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