Has anyone tried tFUS (ultrasound) to reduce plaques or for cognitive enhancement or biologics delivery?

AlexKChen · 2023-12-25T23:32:33.892Z

Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely...

Iaccarino et al [] exposed one hour of light flickering at 40 Hz to awake 5XFAD Alzheimer’s Disease (AD) mouse models, generating action potentials at 40 Hz, activating ~54% of microglia to colocalize with Aβ plaque, acutely, and clearing ...

Butterfly IQ has cheap machines, tho probably not useful for this
also prophetic.ai

FOCUS

Noninvasive Delivery of Biologicals to the Brain

In the past, psychotherapy and neuropharmacological approaches have been the most common treatments for disordered thoughts, moods, and behaviors. One new path of brain therapeutics is in the deployment of noninvasive approaches designed to reprogram...

RapAdmin · 2024-04-11T20:39:41.192Z

a potential breakthrough being tested on humans, not mice.

Revolutionizing Alzheimer’s Treatment: Breakthroughs with Focused Ultrasound (2024)

Suzanne LeBlang, MD, a leading neuroradiologist and Director of Clinical Relationships at the Focused Ultrasound Foundation, delivers an an in-depth overview of how focused ultrasound technology is opening new doors for Alzheimer’s treatment.

Discover how this innovative approach is used to safely open the blood-brain barrier, allowing for effective drug delivery and potential reduction in amyloid plaques. With insights into the results from various global studies and the promising future of focused ultrasound in neurodegenerative disease treatment, this presentation is a must-watch for healthcare professionals, researchers, patients, and anyone interested in the latest in Alzheimer’s care.

Website:

https://www.fusfoundation.org

AlexKChen · 2024-09-19T07:21:28.002Z

https://www.nature.com/articles/s41598-023-39640-2

AlexKChen · 2025-11-11T22:54:31.044Z

profiles.stanford.edu

Raag Airan's Profile | Stanford Profiles

Raag Airan is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors.

just published bombshell papers on tFUS and waste clearance Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models | Nature Biotechnology

This post was ahead of its time!!

[also see An Affordable and Easy-to-Use Focused Ultrasound Device for Noninvasive and High Precision Drug Delivery to the Mouse Brain | IEEE Journals & Magazine | IEEE Xplore ]

AlexKChen · 2025-12-12T03:27:19.940Z

I’ve often told people about the great mass of literature showing that low intensity ultrasound has all kinds of anti-inflammatory benefits in the brain; irrespective of neuromodulation. In the this weeks episode of FUS Forward, Charles Caskey and I catch up with Raag Airan on his new findings where he treats the brain with ultrasound following hemorrhagic stroke. From particles to fluid flow, ion channels to sociopaths, I promise this episode will change the way you think about ultrasound brain stimulation. Links below

LinkedIn ← podcast
LinkedIn ← paper