I “hear” it doesn’t 
and that injection for gut issues remains the gold standard. So I’ve “heard”.
When I read it in an actual clinical trial, we may “hear” something else LoL!
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LukeMV
#22
Very true. I almost fainted the first time I ever injected myself because I was so scared. Now I’m so used to it. Heck, I remember trying to swallow a pill for the first time as a kid and it was a scary experience. Now, I can swallow at least 20 pills with one sip of water (I wouldn’t recommend this however).
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I was not particularly scared the first time but like many “first times” it’s a bit intimidating to get it right
A while back I was doing 7 injections a day
Morning
1x BPC + TB - combo shot
1x Gonadorelin + Kisspeptin 10 - combo shot
1x LL 37 + Ta-1 - combo shot
Afternoon
1x MOTS-c
1x Folistatin
Night
1x IPA + CJC - combo shot - only 5 nights a week
1x LL 37 + Ta-1 - combo shot - short 7 day cycle
For a total of 10 peptides a day LoL!
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That’s a lot of needles. I hope you used a pen for the combos at least!
slightly curious about his combo since they overlap a lot in the receptors they hit. But that’s for another topic hahaha.
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I only HATE the intramuscular (big) needles. These tiny ones are almost fun. I had a lady friend of mine being scared and I pinned myself like 20 times in a row in front of her (just cold pinned with the empty needle) LOL. So, yeah, the I’m scared of insulin needles can’t possibly be an excuse for not doing these miracle drugs/peptides (HGH, GLP1’s etc.)
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I only use Pens now, switched to those a couple months ago. Love them!
The cartridges are easy to fill and it’s a nice system to use. I’ve got all my locals using them.
When I was doing that high count cycle I was filling 100 syringes a week between 2 men and 1 woman (no KGB for her) I stated calling the Kisspeptin + Gonadorelin - KGB - KGB@lls LoL!
Many things overlap;
BPC + TB500 overlap
Ipa + CJC overlap
LL 37 + Ta-1 don’t quite overlap but they are complimentary.
If you note my nick is Steve_Combi - there are a lot of combinations of compounds, peptides and drugs that synergistic in a specific function. I look for those.
Many people on this forum are using combinations of complimentary therapies in the hope of turning back the hands of time.
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After thinking it through and reading the peptide threads, I ordered injectable BPC – 157 and TB 500. Anecdotally I had oral BPC – 157 at home and took a pill last night for the first time. I had the worst stomach pain and cramping and was awake more than half of the night. So much for the oral medication. I’ve got my syringes, needles and sterile water just waiting for the vials of medication from Limitlesslife nootropics
That’s not true. Oral BPC-157 works very well too, you generally just need a bit higher dose to get the same effect as with injections. That said, if you have to choose one way, injections are more likely to work.
In many cases that’s true but in many it’s not. Injections do work better than oral for most things besides gastrointestinal problems. However oral works just as well and sometimes better for gastrointestinal problems. This is not only clear from anecdotes but the animal literature is full of studies showing effectiveness of oral BPC-157. Also, regardless of whether one is afraid of needles or not, injections always carry extra risk compared to oral. I know of a case where a person got anaphylactic shock from injecting BPC-157 and almost died. Had he taken it orally the risk would have been lower, and he would have more time to get to a hospital after getting an allergic reaction because things are absorbed more slowly orally than by injection.
From what I have read, BPC-157, in addition to lower bioavailability, it works mainly on stomach and gut problems.
The oral form works on other things too, there is plenty of evidence of that. The reason fewer people see benefits with oral for things other than gastrointestinal problems is partially related to the dose (typically people often twice as much for the same effect as if they were injecting it) and also that some may be taking bogus brands. Poor brands are not as serious of an issue with oral than with injections. It’s much more serious to not get what you expect for things you intend to inject than things you intend to ingest. Therefore I expect there to be more bogus oral brands than injectable brands out there. So oral is more of a hit or miss. Note that I have seen people that got benefits from oral when injectible didn’t work and also vise versa. The latter is more common for the reasons I mentioned.
Yes, and a higher cost. I understand some people are nervous about subcutaneous injections, but think about the millions of people who do it every day to control their type one diabetes, many of them frail and elderly.
Also think of the tens of thousands of gym rats injecting God knows what.
I haven’t read a ton of horror stories on X or Reddit, etc., from people using peptide subcutaneous injections.
How many thousands are there are injecting Ozempic etc.
So, some people have phobias about this, so for them taking peptides orally might be better than nothing.
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I don’t really disagree with that aspect. It does work orally for the gut. But it’s not as bio-available as the current crop of marketing on FB and Insta would have people believe. Those companies are not telling the whole truth when they say 99% bio-availability orally, that is a marketing lie. They are promoting oral only because it’s easier and they can make more money selling it in a more “conventional” but overall less effective format.
For soft tissue healing SubQ is superior.
BPC 157 works great, I’ve been using it in a 1:1 combo with TB500 (frag 1-4) every day for 2 years. 500mcg+500mcg every morning in a SubQ shot. Occasionally I will double up and do a night time shot if I’ve done something that would benefit.
BPC 157 is considered to be systemic but it has to spread to where the injury is before it’s half life is reached. The half-live is probably 30 minutes with complete wash out in 4 hours. Orally is not going to cut it, considering you can inject as close to an injury site as required and deliver the benefit before it is reaches the half life.
If people don’t mind wasting money on something that may not get to the site, it is up to them. If their gut is the only issue, that is a different matter, then it comes down to effective oral dosing.
Even when injected SubQ it is not 100% bio-available so I’d guess it’s lower again orally.
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It’s a bit of an exaggeration but bioavailability isn’t far from 99% specially if you take the arginate salt that is even more resistant to degradation in stomach acid (the arginate form breaks down less than 1% after several hours in the stomach).
That depends on what you mean by superior. It’s superior in terms of you typically getting the same effect with a lower dose and also superior in that depending on your problem sometimes you can get higher potency at lower doses by injecting close to the injury you want to treat. Other than that it’s not superior.
I disagree. 30 minutes is plenty of time for it to circulate multiple times throughout the blood circulation and passing the injured tissues that can take it up as needed. I’ve read a lot of the animal studies and in almost all those I’ve read orally worked just as well as injections at the same dose. The anecdotal evidence also suggests that oral reaches every part of the body that injections do because I’m not aware of any type of injury that injections have fixed but oral has not. The main difference in the end is the dose and cost. In that sense, injections are better, but oral will give you the same results if you take a good brand at a high enough dose.
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I have to assume you are specifically talking about BPC 157? because there is some substances where subq is way more bioavailable than oral. I.E I’m hearing that taking glutathione orally is almost a waste of money as the bioavailability is in low single digits but subq is way higher. I’m nowhere near an expert on these topics, but I’m sure there is many more.
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Yes, to be clear, I’m specifically talking about BPC-157 here. Most other things, particularly other peptides, are far more bioavailable with injections than oral. BPC-157 is very unusual among peptides in that it is very stable in gastric acid so it survives the stomach and is able to be absorbed. Most other peptides get destroyed in the stomach and are not bioavailable orally. You’re right, glutathione is not bioavailable orally and it’s exactly because it gets destroyed in the stomach before having a chance to be destroyed.
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Beth
#36
Ha, I have often said, that is going to be how I die!!! Every once in a while there is a split second when I’m slightly nervous!
I’ve heard Huberman share the time he grabbed a handful of pills out of his pocket and he swallowed his AirPods!
A doc had me start B12 shots many years ago, and no, they didn’t think to give me an insulin needle (I learned that here!). I’ve told people that if my wimpy self can do that, ANYONE can!!!
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The mean absolute bioavailability of BPC157 following IM injection was approximately 14%–19% in rats and 45%–51% in beagle dogs.
I’m not too sure about 99% in humans as the paper I provided does not support that in animal studies. There are very few human studies on the pharmacokinetics of this peptide, I can’t even find one yet. If you have one, I’d love to read it.
This is one of the better ones that explains how it works but no human data.
https://www.mdpi.com/1424-8247/18/2/185
How long does it take to digest and get into the blood stream? Does that happen in the stomach? in the upper intestine? and/or the lower intestine? That may not matter as it is a very stable peptide, until it gets into the blood stream.
Instantaneous with SubQ = max benefit.
Regardless of this little debate BPC 157 is pretty amazing in my personal experience and in the 30 or so local folks I have using it. Some with pretty severe issues, like taking a shotgun blast to the left shoulder during a home invasion, losing half the muscle in that area and recovering like a champ and another who did breast augmentation and stunned her Doc with her rapid healing, such that he was very interested in knowing what she was doing and another who had heart surgery 4 years ago, failed his first 2 stress tests and now has aced his last 2 stress tests, his Dr is wondering how this could be.
So I’m sold on BPC 157 and especially the following combo as that is what the above examples have been using.
One reason I do SubQ is that I use it in a combined shot with TB500 (frag 1-4) so I only need to take 1 shot for 2 peps
I also do other combos,
Ipamorelin + CJC 1295 noDAC (400mcg+250mcg) - 5 nights a week for 2 years
Gondorelin + Kisspeptin 10 (133mcg + 165mcg) - 5 mornings a week for the past 6 months
Keeps the poke count down a bit LoL!
Do you have a fav peptide that you use?
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@Steve_Combi what injection pen are you talking about? Can you clarify?
I know very little about all this, and stands to reason that subcutaneous must work better but Ibutamoren is one example where oral works just fine.
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They look like this. You put the reconstituted peptide in the disposable cartridge and you use disposable screw on needle tips. You turn the dial to the desired dose and away you go. No more syringes.
I’ll never go back
What is an insulin pen?
An insulin pen is a device used to inject insulin.
https://www.drugs.com/cg/insulin-pens.html
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@medaura I just bought a few this morning from allthingspeptides.com.
horizonpeptidesupply.com seems cheaper but I needed 32G needles and bac water at the same time.
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