Highlights from ARDD 2024

[Curious]

A great talk about anti IL-11 therapy.

Anissa Anindya Widjaja at ARDD2024: Inhibition of IL11 signalling ... healthspan and lifespan

[LukeMV]

Maybe we can start a thread where we speculate on which supplements/drugs/etc. would be contraindicated with one another. I still am a staunch believer that most things work better in combination, and negative interactions are more the exception.

[RapAdmin]

I found this presentation from on Organ Aging interesting…

Interesting, foods have different impacts (sometimes positive, sometimes negative) on different organs:

and, men and women age differently:

Vadim Gladyshev at ARDD2024: Organ aging and rejuvenation

[Joseph_Lavelle]

I had a hard time understanding the speaker. Did he say how they associated foods with outcomes? Food diaries? Foods / alcohol would have short and long term (from repeated consumption) effects. But it’s an interesting study.

[JuanDaw]

Study referred to at 8:27, below.

https://www.nature.com/articles/s41586-023-06802-1

11:39 Association of smoking with different organ clocks

Smoking has a greater negative effect on the liver, and intestines than the arteries. What?

12:26 Association of foods with the arterial model
Wine (red or white) has a positive effect (blue bars), effect of full fat yogurt is negative (red to pink bars).
That is common knowledge, now confirmed by their model.

Curiously, sugary drinks have a lower negative effect on arteries (pink) compared to Plant-based spread, lower fat (red bar).

12:35 Association of foods with the intestinal model
Wine and full fat yogurt trade places. Wine is bad, yogurt good.
Oily fish, muesli, and unsalted nuts and seeds are good for both arteries and intestines.

[RapAdmin]

@Joseph_Lavelle

Did he say how they associated foods with outcomes? Food diaries? Foods / alcohol would have short and long term (from repeated consumption) effects. But it’s an interesting study.

Its all data from the UK Biobank. Here is the pre-print study I believe:

A compact protein panel for organ-specific age and chronic disease prediction

[JuanDaw]

Plasma-based organ-specific aging and mortality models unveil diseases as...

We also assessed the associations of diet with biological age as measured by our mortality-based models (Fig. 5b). UK Biobank e-mailed online 24-hour recall dietary questionnaires to participants after their first visit. Using this information as a proxy for dietary habits, we assessed the associations of 93 different food groups on biological age as predicted by our organ-specific aging models, after correction for sex, biological age and their interaction.

[RapAdmin]

At the 19:00 min mark he discusses using both rapamycin and calorie restriction as comparative element in aging vs. partial cellular reprograming.

Vittorio Sebastiano at ARDD2024

[John_Hemming]

I think I have now got to a point where I can do a short UA test with a CGM. I am thinking I should take a single large dose of UA and see if it seems to make any difference with glucose. Looking at rat experiments even at 5% of diet no adverse effects were seen. Hence 10g in some yoghurt should be both safe and a sufficient amount of move the needle if indeed UA will move the needle.

Does anyone have any thoughts on this?

Its half life is 17-22 hours so one would expect a movement over the next 48 hours, but then for things to settle down. I am not inclined to accelerate blood tests although I may time it to suit my test next monday.