Dear All,
I am wondering if anyone has tried Honokiol, there was a very promising report related to some small molecules based/derived from it?
Innovative therapies revive a once-undruggable mitochondrial aging regulator through a revolutionary enzyme activation mechanism.
Researchers at CCM Biosciences, Inc. have leveraged a novel biophysical mechanism of enzyme activation to discover and characterize groundbreaking enzyme activators for a previously untargetable master regulator of cellular energy production.
Recently, a team of scientists at CCM Biosciences and its affiliated R&D center Chakrabarti Advanced Technology expanded the scope of enzyme activation beyond allosteric modulation by introducing new physical principles for enzyme activation and successfully applied computational and experimental design methods based on these principles to identify new compounds that dramatically enhance the activity of previously undruggable enzyme Sirtuin-3 (SIRT3), which is centrally involved in regulating human aging. This study was published in Physical Review X , the flagship journal of the American Physical Society (APS), on October 22, 2024.
https://scitechdaily.com/longevity-breakthrough-scientists-restore-youthful-enzyme-activity-to-combat-aging/
https://x.com/Dr_Singularity/status/1881041189224235011
Kindest wishes,
Martin
It seems very early in the research (this specific research), and this is from a company, so I take it with a grain of salt until its repeated by some independent labs.
I think SIRT6 is showing much more potential.
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