#52

Right, I missed the word ‘his’. And I didn’t listen long enough.

Like I said, I get stupider with every passing year.

From the joint or muscle pain point of view, I have osteoarthritis in my fingers and toes, but it’s only really painfully apparent on occasion between my right thumb and index finger. So another marker where I’m looking to see if there’s some improvement over time.

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#53

I was suffering from pain in my left thumb lower joint… was constant… arthritis- gone after 4 months on rapamycin… also was having some shoulder pain…left and right… fully resolved… now 3 years out…doing pretty substantial weight lifting targeting shoulders… no pain… no recovery time after workouts.

Literally pain free in entire body… no neck, back pelvis or knee pain.

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#54

Hi @timsbq

I’m a ME/CFS and Fibromyalgia sufferer (age 49, 20+ years, post-exertional malaise [flu-like feeling, fatigue], headaches, body aches, unrefreshing sleep) who is also eager to try rapamycin.

I did a research summary for rapamycin for ME/CFS and anti-aging in general here:

There’s an encouraging blog article on Health Rising about a 79-year old physician who got remission from his 10-year ME/CFS after six weeks of rapamycin 6 mg, although commenters reported more mixed results.

There’s also this in vitro study on ME/CFS lymphoblasts that indicate elevated mTORC1 signalling activity:

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#55

Great research summary!

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#56

Can you please give me the link to the parabiosis clinical trial that you are using

#57

Plasmapheresis, not parabiosis… Here, thought they’ve already fully recruited for the study: Plasmapheresis Startup Looking for Clinical Trial Participants SF Bay Area

Here is another one I’ve heard of:

Link: RB - MaxWell Clinic

We are thrilled to announce two exciting new clinical trial opportunities at MaxWell Clinic! Our team is dedicated to advancing medical research and providing our patients with the latest and most effective treatments.

Let’s crack the code on aging, the number one cause of chronic disease. This is the most advanced study ever conducted into the age-reversal effects of plasma exchange. We’re recruiting a committed cohort for a paid trial to evaluate plasmapheresis as a potential rejuvenation/regeneration therapy. Specifically, this trial will be conducted to gather data on the impacts of plasmapheresis on aging, neurodegeneration, vascular health and immune function.

Plasmapheresis is an FDA-approved procedure for more than 50 indications and it has been shown to improve a range of health measures. We believe it may be beneficial for even relatively healthy individuals.

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#58

I have to get esophageal dilation every couple of years. If rapamycin offers relief that would be extraordinary! Anyidea what mechanism makes this effect happens? Today was day 2 of 1 mg rap. :crossed_fingers:

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#59

Yes, of course the potential of improvement depends on the person. For me the neurological problem of dysphagia (choking) was remedied in about 6 months from rapamycin use. Nerve cells are specialized and the toughest to figure out. We know rapamycin cleans and restores all cells… nerve cells included.

I can now wolf down the driest bread or thickest, dry chunk of meat with no liquid .

I struggled for years… just knew I would die from choking. Now I eat never even think of it… steak… no problem.

My son who is 30 years had similar choking on food issues (hereditary?)

For him cured , after 3 months use of rapamycin He stopped using rapamycin at 6 months and problem hasn’t come back.

IWhen I shared how rapamycin cured my dysphagia… Researcher Matt Kaeberlein was intrigued… not impossible.

Needs a human clinical trial… but when?

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#60

Wow, what’s your dosage and frequency?

#61

I’m using dosing 8mg to 10mg once per week. Have been on this schedule (with variations testing higher, up to 28mg effective dose, but then once every 2 weeks) for almost 4 years now.

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#62

For my first cycle of ramaplycn I used 2mg per week for 10 weeks and despite the low dose noticed some positive effects both physically and psychologically as well!

I’m currently on my second cycle in which I’m currently taking 5mg per week and I’m going to run it for 6 weeks!

Caution is always the wise choice when experimenting with ramaplycn especially if your new to it!

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#63

Would be nice if I don’t need reading glasses. I’m finally targeting about 10ng/mL after 24 hours. See how I go in 12 weeks.

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#64

I haven’t been using reading glasses for over a year now. Can’t be 100% sure it was the rapa but one way or another I’m good to go. I do attribute part of the help to getting a smart phone that refreshes 120 times a second. When scrolling, 60hz screens appear to stutter which was killer for my eyes. Also I stopped playing video games on my phone, as I had a tendency to over-intensely focus to such a degree that my eyes would be sore the next day.

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#65

I wrote this before. I have myopia. Definitely my visual acuity improved tremendously after rapamycin. I take 2mg a week and I started noticing this effect in the first week. Colors are more vivid, I see distances more clearly. I had slight dry eyes and even that fixed it. I don’t have to use as many artificial tears as I used to.

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#66

I’m in the “haven’t noticed any changes, good or bad” group. No side effects. I didn’t have any “old age problems” (aches pains etc) that were cured. Far as I know my vision hasn’t gotten better, and I do get an eye test every year. This leaves me wondering - is the rapa actually working? I guess the only way to tell is if I don’t die. =)

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#67

I have been increasing my dosage, and I am feeling more fatigued but not in a euphoric way. I think it’s my body signalling that I need to cut back. I will try a 14 mg equivalent (4 mg + GFJ) bi-weekly protocol to see if that helps the fatigue.

Or it could just be that life has gotten more stressful. :stuck_out_tongue:

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#68

Destrider, have you ever done a blood test after 2 hours or 24 hours?

I definitely feel fatigue on the day. I know my psoriasis has definitely reduced, more on the first day and it creeps back later from say 4th day onwards. One of my problematic joint pain in my left finger is almost gone. The other more severe one is at 50% of the original pain.

I’m currently on 12mg with GFJ. I know from the blood test it peaks well over 30ng/L and around 10ng/L after 24 hours.

Should I increase to 14mg or should I keep the current weekly at 12mg for another 6 weeks first?

Patience is definitely not one of my virtue :joy:.

Perhaps another 10 weeks and then decide. I’m of the opinion that a higher dosage and maybe a longer delay in-between dosage is better than continuous low dosage.

#69

Are you taking 12 mg + GFJ? That’s be 36 mg equivalent. If so, you’re definitely running the risk of MTOR2 inhibition.

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#70

I know people who have taken much more … I am only taking that amount because of the stupid brand… Siroboon. I monitor based on the level of siromilus in my blood after 24 hours. I am within the safe limits that Bryan Johnson described. He takes 13mg, then 6mg on alternating weeks.

“Blood Rapamycin levels:
90 min: 26.5 ng/mL
4.1 days: 2.5 ng/mL
13 days: not detected”

I dont think my rapamycin quality is that good despite of all the steps I take. I now just need a history to convince the local doctor to prescribe to me. lol

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#71

All you needed to mention was Siroboon. I understand now. :slight_smile:

Your 15 mg of Siroboon is 1.5 mg normally.

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