I don’t know exactly what type of plasmapheresis they are proposing in this trial, but here’s a link appearing to provide more details and discussion.
In a seminal paper by Conboy, they replaced old plasma and replaced half with saline/albumin.
A personal communication from Conboy comparing to blood donation:
“For the paper, we changed out about half of the plasma in the mouse, and the similar procedure for humans changes out around 90% of the plasma. Donating a unit of blood removes a pint, from a total of around 5 quarts, so only around 10%. So “in theory”, I doubt the benefits of a blood donation could be as dramatic as what we observed for the paper. But it might have more subtle benefits”
I have been donating every 8 weeks for years, original motivation to dump iron (another intervention/thread), but appears to be rejuvenating at multiple other levels. At my pace and blood donation qty, I am completely replacing my systemic blood/plasma, every 18 months.
https://www.aging-us.com/article/103418/pdf
“Our data demonstrate that a single NBE suffices to meet or exceed the rejuvenative effects of enhancing muscle repair, reducing liver adiposity and fibrosis, and increasing hippocampal neurogenesis in old mice, all the key outcomes seen after blood heterochronicity. Comparative
proteomic analysis on serum from NBE, and from a similar human clinical procedure of therapeutic plasma exchange (TPE), revealed a molecular re-setting of the systemic signaling milieu, interestingly, elevating the levels of some proteins, which broadly coordinate tissue maintenance and repair and promote immune responses. Moreover, a single TPE yielded functional blood rejuvenation, abrogating the typical old serum inhibition of progenitor cell proliferation. Ectopically added albumin does not seem to be the sole determinant of such rejuvenation, and levels of albumin do not decrease with age nor are increased by NBE/TPE. A model of action (supported by a large body of published data) is that significant dilution of autoregulatory proteins that crosstalk to multiple signaling pathways (with their own feedback loops) would, through changes in gene
expression, have long-lasting molecular and functional effects that are consistent with our observations. This work improves our understanding of the systemic paradigms of multi-tissue rejuvenation and suggest a novel and immediate use of the FDA approved TPE for improving the health and resilience of older people.”
Here’s a study on 915 50 yr olds using Double filtration plasmapheresis (DFPP).
Application of biological age assessment of Chinese population in potential anti-ageing technology
Results
“Based on the comprehensive blood test and analysis, the ageing biomarkers were screened, and the male and female biological age assessment formulas were established. Then, the elimination of ageing biomarkers by double filtration plasmapheresis was examined. Double filtration plasmapheresis can eliminate ageing biomarkers, with an average of 4.47 years decrease in age for males and 8.36 years for females.”
