#143

As I was in the energetic/euphoric group when I took Rapamycin, I believe the feelings were due to physical repair as my body reduced senescent cells, inflammation and general crap floating around my body (through autophagy). I believe I felt better because I was getting healthier. Over the years, the feeling has slowly faded until it has become fairly neutral. Maybe I’ve done enough bodily spring cleaning? I also experience a euphoric fatigue that knocks me out a little the day after dosing, but this has been fading as well. Maybe I’m developing resistance to Rapamycin? These are all my conjectures.

I also sometimes get intense pain in my GI tract or stomach like this past dose. Sometimes I also get rashes if I inhibit MTOR for two long (2 large doses back to back each week). I find I don’t get rashes if I wait two weeks between doses.

The other factor is that I am continually modifying my stack. I’ve added prescription drugs and other supplements that may be additive, subtractive, synergistic, or neutral in regards to my other changes. It’s really hard to tell.

All I can say with 100% certainty is that the amount of diarrhea I have has gone down dramatically since I removed Resveratrol from my stack! :wink:

Sometimes we all make newbie mistakes that take a while to correct.

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#144

can I know your age ? Thanks

#145

I am 50 years young. So approaching mid life. :wink:

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#146

I will “posit” a few thoughts:

  1. If you are doing a relatively hard workout, you probably have a stew of hormones post-workout (Adrenalin, Corticosteroids, etc) that mix with the Rapamycin pharmaceutical effects. My experience and general reading of this site is that people who exercise or train take Rapamycin on their active rest days. Walking or zone 1/2 training levels. And exercise and fatigue is a dangerous mix over time. Don’t over train and go by how you feel - your body is communicating quite bluntly to you and I sincerely doubt a higher dose of Rapamycin within your training regiment is a good thing.

  2. I was startled to read a post on here of someone stating that they are good at taking drugs. In other words, they can live easily with the various impacts of drugs that I am quite adverse to. (I think most people on the forum would kick sand in my face as they are the Charles Atlases of self-experimentation : ). So I have been open to taking Rapamycin at various dosages and periods depending how my sleep, energy levels, emotions feel. I think some of the benefits of Rapamycin works, in my case, when I am off it.

  3. Another general reading of this site, those that go high with their dosage eventually go back down. You seem to have gotten some profound benefits. Maybe if you were older you might contemplate going higher, but I would suggest either a steady state, or take a Rapamycin vacation and log how long certain benefits last. Taking a higher dose requires you monitor blood levels of lipids and sugars as those are signs of MTOR2 inhibition. Over time things like sleep etc have gotten much better and even improved for myself in contrast to the first year of taking Rapamycin.

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#147

I went a couple years taking it in the morning and when people on here said to take it before bed I tried it just on a whim. Never went back. Best sleep I get is every 2 weeks after my Rapa. I try to fast a little the day before, but not a lot just enough to be a little hungry. So maybe 10 hours.

If you don’t like how it’s working, then try it another way. It makes a difference to me.

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#148

Yes, good point about the hard exercise on the morning of rapa dose. I’ve definitely heard that others rest. My probably erroneous thought was that I could slip in exercise before my dose and rest after. I thought that training hard after rapa would be ill advised, but training before would be fair game. lol. Perhaps that was wishful thinking.

I was someone who was feeling impacts on doses as low as 1 mg, so I am inclined to return to 2 mgs. I’ve only done about 6 doses so far and will be taking a two week break at 8 weeks. Perhaps I will also dose every 14 days instead of weekly to ensure better washout between doses or take more frequent breaks.

Luckily, I did buck the trend of poor sleep after Rapa last night. I dosed yesterday morning and slept soundly last night. Let’s hope this continues! If not, yes to experimenting with nighttime dose as bicep does.

Finally, I face the challenge of too many variables, many of which I have introduced myself. For example, is my now fading age spot due to oral rapa, topical melatonin, or something else, including wishful thinking?!

I appreciate any and all responses and find them very insightful. This self experimentation journey is quite complex.

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#149

I had all these symptoms, at different times, too, and I’m female and a bit older than you. My first dose came with dizzy and mild nausea. For a good year, I had the marvelous energy and focus boost, then, increasingly, fatigue similar to what you describe.

My theory is that for some of us rapamycin induces EBV reactivation. Why rapa brings on EBV-ra for some of us and not others, when nearly everyone has EBV, I don’t know. Why it didn’t for me the first 6-8 months, at higher rapa doses, but does now, at lower doses, I don’t know. But EBV may play a role in the fatigue.

And you may find, as many of us have, that your reactions change with time.

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#150

Yours and your friend’s weight is different, but it seems that you are taking the same doze. IMO it’s a mistake. Reduce your dose and see how you feel.

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