https://x.com/MitoPsychoBio/status/1889122483921404339?s=19
https://www.nature.com/articles/s41586-019-1911-y
https://x.com/SamuelBHume/status/1889358210492146171?s=19
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metformin increases gdf15 and gdf15 accelerates aging: "So GDF15 is a protein that’s raised (and driving pathology) in cancer, aging, and a range of other conditions
The good news is there are antibodies to target it, and the emerging data are very promising
Sources:
GDF15 as a predictor of disease https://cell.com/cell/fulltext/S0092-8674(24)01268-6
GDF15 in aging https://cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00041-2
Targeting GDF15 in cancer cachexia: https://nejm.org/doi/full/10.1056/NEJMoa2409515
Targeting GDF15 to overcome resistance to immunotherapy: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours | Nature"
does this reduce the other anti-aging effects of metformin?
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