#916

This is interesting! My skin is as dry as the Sahara. For the first time, I just ordered hyaluronic acid in pill form to see if I could moisturize from the inside out.

Is that the effect it had on your skin? Or did you mean something else when you said it helped smooth your skin? (Aside from dehydration, my skin is pretty good).

I imagine you got this from his fullscript store!

@Joseph_Lavelle any comments on tremella ?

1 Like
#917

Fullscript is correct. I am a little busy and just didn’t have time to look it up.

All the rough areas become smooth. It’s crazy how fast it works. I’m interested in finding out how it works on other people. Most of my problems seem to come from my skin being so thin and that seems to cause wrinkles too. There’s no plump. This seems to help noticeably.

3 Likes
#918

Black Friday has arrivedfor the NIRA laser

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#919

Thanks, I thought I’d been cleaning up senescent cells with Rapamycin. I’ve been taking it for over 2 years and generally feel fantastic, except for my worsening hands. Will you do this FOXO experiment with or without Rapa?

Re tests, yes I’m Canadian too but planning to get some tests, including Rapamycin levels, done in San Diego when I visit there soon. If anyone has a lab to recommend, let me know. Labcorp had a heckuva time dealing with my lack of US address even though I used my son’s.

1 Like
#920

While Rap does have senolytic properties and inhibits SASP, I do not think it is the best nor the most effective senolytic.

I will continue to do our Rapa cycle as we introduce FOXO4-DRI. My approach is to maintain my baseline. Our baseline currently includes a lot of things so I like to leave that “as is” when I add or try something new unless there is a conflicting issue.

I have not read enough to fully understand how effective Rap is nor what the effective dose is for it to act effectively on senescent cells. When it comes to senolytics, dose often critical. For example Quercetin is not a senolytic at low does. What is a low dose of Q? under 2000 to 3000mg it’s not very good at all forthat purpose but it’s beneficial at low 500mg doses for other things.

Rapa is more of an inhibitor of senescence. But again, at what dose? and in humans or mice?

AI Overview

Yes, rapamycin has senolytic-like properties:

  • Senescence suppression

Rapamycin can suppress senescence and the senescence-associated secretory phenotype (SASP).

  • Cellular senescence inhibition

Rapamycin can inhibit cellular senescence in multiple cell types, including fibroblasts.

  • Senescence delay

Rapamycin can delay entry into senescence in cells treated with chemical stress, ionizing radiation, and other factors.

  • Senescent cell reduction

Rapamycin can reduce senescent cell subpopulations.

Here is an article by Mikhail V Blagosklonny whom most of us taking Rap are aware of.

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#921

It is working amazing for me. 30 days in :slight_smile:

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#922

Crap… If @Walter_Brown and @Bicep say something is good… That means l will be getting another supplement.

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#923

I’ll placing an order with them today and can’t wait to try this. TY! I’ll let you know.

Darn, wish I hadn’t ordered the hyaluronic acid, but I’m committed now!

2 Likes
#924

Has anyone tried using microneedling (derma) rollers at home? What results have you seen, especially when it comes to wrinkles and expression lines?

1 Like
#925

Mike Lustgarten’s new video interview:

Human Skin Rejuvenation: Li Li, PhD

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#926

What benefits did you notice? I bought it but didn’t start yet.

#927

derma-rollers are generally not recommended by derm
this may be a better option

3 Likes
#928

Here are Cliff notes of the Video

Aging is characterized by a gradual decline in function, partly due to accumulated molecular damage. Human skin undergoes both chronological aging and environmental degradation, particularly UV-induced photoaging. Detrimental structural and physiological changes caused by aging include epidermal thinning due to stem cell depletion and dermal atrophy associated with decreased collagen production. Here, we present a comprehensive single-cell atlas of skin aging, analyzing samples from young, middle-aged, and elderly individuals, including both sun-exposed and sun-protected areas. This atlas reveals age-related cellular composition and function changes across various skin cell types, including epidermal stem cells, fibroblasts, hair follicles, and endothelial cells. Using our atlas, we have identified basal stem cells as a highly variable population across aging, more so than other skin cell populations such as fibroblasts. In basal stem cells, we identified ATF3 as a novel regulator of skin aging. ATF3 is a transcriptional factor for genes involved in the aging process, with its expression reduced by 20% during aging. Based on this discovery, we have developed an innovative mRNA-based treatment to mitigate the effects of skin aging. Cell senescence decreased 25% in skin cells treated with ATF3 mRNA, and we observed an over 20% increase in proliferation in treated basal stem cells. Importantly, we also found crosstalk between keratinocytes and fibroblasts as a critical component of therapeutic interventions, with ATF3 rescue of basal cells significantly enhancing fibroblast collagen production by approximately 200%. We conclude that ATF3-targeted mRNA treatment effectively reverses the effects of skin aging by modulating specific cellular mechanisms, offering a novel, targeted approach to human skin rejuvenation.

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#929

ATF3 protein levels are also increased (in liver and fibroblasts, at least) in a number of long-lived mice (rapa, acarb, CR, and methionine restricted).

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#930

Looks like a version of meso therapy.

I have seen versions of this system for sale in a few places, many much cheaper. It does look promising. I might try this. But one thing, how do you make sure the serum is really going out if the bottle is pointing up or horizontal? Lools loke you would need to do this with ones head highly elevated or lying down.

I a micro needling once a month. Awhile ago i dismissed derma rollers because of the mechanical problem that they tear as much as pierce when the roll. But also I was worried about keeping them clean. I dump my needle cartridge after every session.

1 Like
#931

You give the old mercury thermometer reset shake, that forces the serum out of the bottle and on to the needles. I do that before each row.

I started using the system once a week. I have no issues with any recovery next day, I think my skin maybe a bit thicker that needle size is design for.

They recently added Copper Peptide GHK-Cu to their serum selection, there is a bunch left over in a bottle after you are done so I will use it on top of my head - it supposed to help with hair growth as well.

BTW, we always talk about treating the face directly but SCALP thinning is a big part of sagging face. There are just not enough products for scalp skin treatment. Treating scalp is hard because of the hair as well.

3 Likes
#932

How to nurture your microbiome to look after your skin

Our skin is host to a thriving community of bacteria, some of which help to restore and protect our epidermis. The hunt is now on for treatments that make the most of these allies

Beneficial skin bacteria could also be the key to maintaining a smooth, wrinkle-free appearance. Our skin is like a fortress constructed from layers of skin cells packed together. In between the cells are lipids that keep the skin supple and plump, and certain bacterial species help to replenish those stores.

“Cutibacterium stimulates the skin to produce sebum, which protects the skin, reduces water loss and increases hydration,” says Holly Wilkinson, who studies wound healing at the University of Hull, UK. Staphylococcus epidermidis and Streptococcus thermophilus can produce ceramides, meanwhile, which can also reduce water loss and protect the skin barrier.

Read the full article: How to nurture your microbiome to look after your skin (NewScientist)

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#933

What the evidence says about the consequences of cosmetic tweakments

Laser therapy, microneedling and vampire facials are among the bizarre, non-surgical treatments that have become widely available, but their evidence base is decidedly mixed

In recent decades, a number of laser, radiofrequency, ultrasound and intense pulsed light devices have been introduced that can ostensibly restore that youthful glow. Developed from treatments to promote wound healing and reduce scarring, these technologies all involve waves of energy penetrating the outer layers of the skin to heat it from within.

“If you heat the skin up enough, you basically stimulate a kind of a wounding response,” says Kiely, which then spurs the body to produce collagen and elastin to heal the damage. “So you’re playing with the body’s ability to repair itself.”

Read the full story: What the evidence says about the consequences of cosmetic tweakments (NewScientist)

The only four skincare ingredients that have been proven to work

In the quest for better skin, we are faced with an overwhelming choice of creams and serums to enhance our appearance. Here’s what works – and what doesn’t

Deciphering claims about these ingredients can be tricky. “Every year, there are at least three more ‘miracles’ on the market,” says Fu’s colleague and fellow chemist Gloria Wu. However, in their book, Skincare Decoded , they focus on the “big 4” – ingredients with the strongest evidence to back up marketing claims. These are retinoids, vitamin C, niacinamide and alpha hydroxy acids (AHAs).

Read the full story: The only four skincare ingredients that have been proven to work (New Scientist)

Forget aesthetics, the reason to look after our skin should be health

New research shows that ensuring the skin is in excellent condition should be a priority for anyone who wants to increase their chances of living a long life

There are many other reasons to take care of our complexion besides cosmetic concerns, however. According to new research, its condition can have knock-on effects for the rest of the body. Due to the dense thicket of blood vessels running under the surface, inflammation that starts in the skin can easily spread to the heart and the brain, increasing the risk of cardiovascular disease and dementia, for instance. Wrinkles aren’t just a projection of our age – they can actually drive the ageing process. And so we should think of skincare in the same way as exercise: the best reason to do it isn’t for looks, but for the undeniable health benefits.

Ensuring our epidermis is in excellent condition should therefore be a priority for anyone who wants to increase the chances of living a long life, which is why we have produced a special report on what we know about the best ways to care for it (see “Why looking after your skin is so crucial to your long-term health”).

Read the full story: Forget aesthetics, the reason to look after our skin should be health

Relacionado:

Their blog: The Blog | Chemist Confessions

This seems like a pretty good science-based skincare podcast (your comments welcome). They are trained chemists, and “former L’Oréal formulators Victoria Fu and Gloria Lu have taken off their lab coats to reveal what the job is about and demystify skincare”.

As two skincare chemists with an equally terrible sense of humor, our friendship began in the cubicles of a big beauty company. Together, we began dreaming of a different approach to skincare - one in which the chemists’ voice no longer fell by the wayside to marketing trends and the customer had the knowledge to navigate the overstated claims and underwhelming results that is the skincare-industry-cyborg -machine. Source: About Us | Chemist Confessions

also available on youtube:

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#934

A reminder for anyone taking rapamycin (you need to wear sunscreen all year):

Ivan Litvinov, a dermatologist at McGill University in Montreal, Canada, agrees that the benefits of using SPF in winter outweigh any potential risks. Sunlight triggers the production of vitamin D in the skin, but the amount produced at higher latitudes at this time of year is negligible, he says – and it can easily be remedied with supplements. Anyone with a family history of melanoma, with very fair skin or who is taking immunosuppressants or medications that make you more sensitive to UV light should always wear sunscreen, he advises.

Read full article: Should you really wear sunscreen all year round, even in winter?

3 Likes
#935

@LaraPo

If you order from a pharmacy, I suppose you can bypass the RevitaCare Laboratory, which sells only to medical professionals. Or maybe your nursing license is still active? Do they check? How’s your French? How do you order and how do you pay? You’d think that there would be a U.S. equivalent.

Thanks.