#936

You do not need to speak French or have a license. All kinds of fillers are available for sale in Europe or Asia. Everybody speaks English. Just google the product you want to buy. It’s that easy.

2 Likes
#937

I have found this site in Italy. 230 €, about 230 US$ for 10 vials 5 ml each, at least this is how I construe the info.
Is 5 ml enough for a full facial application and how often should it be applied? I’m trying to figure out what would be the monthly cost of this treatment.

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#938

5 ml is enough for the full face one time application. The price is good, shipping can be expensive though. You do not need to apply it every month. After you apply it for the first time, wait at least 3 weeks and re-apply again. It’ll last for 6 mo at least. Pls provide a link to the site.

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#939

Thanks, LaraPo, this is a site in Repubblica di San Marino, a microstate inside Italy, where I live, and they do domestic shipping at a nominal price of 1 US$ so it seems overall good. My doubt now is what is the optimal means to apply it, in the site they say you can use mesorollers or dermal pen or similar methods. This is an alien subject to me and even my wife does not know the product.

I checked the site and they ship to Europe including UK, they do not list overseas destinations but of course you can enquire and if you have difficulties let me know, I think it’s easier to talk to assistance from here.

CYTOCARE 532 10 x 5 ml - Pillola Store.

1 Like
#940

It is designed to be injected with a small (3-5 ml long) syringe, using a very small needle (30-32G, 2-13mm long). The length of a needle, from 2 mm to 13 mm, depends on the area where you want to inject and the injection angle. For example, if you want to infect in a single spot vertically, use a 2-3 mm needle. If you injecting under a longer wrinkle, use a 13 mm needle for angular I jections. I would recommend that you watch a video on YouTube how to I inject CytoCare.

Here are some common injection techniques used for administering CytoCare 532:

  1. Nappage: This technique involves multiple small injections across the treatment area to evenly distribute the product.
  2. Point-by-Point: Injections are made at specific points to target particular areas of concern.
  3. Retrotracing: The needle is inserted and then withdrawn while injecting the product, creating a linear deposit.
  4. Fan Injection: The product is injected in a fan-like pattern to cover a larger area.
  5. Cross-Hatching: Injections are made in a crisscross pattern to ensure even distribution and coverage¹²³.

These techniques can be performed manually or with a mesogun, typically using 30G needles. The injections are usually administered into the medium or superficial dermis of the face, neck, and back of the hands¹³.

If you have any more questions or need further details, feel free

4 Likes
#941

@LaraPo,

Do you have any suggestions for undereye circles? Everything I have tried, including hyaluronic acid, makes them worse.

Thanks.

#942

I’ll be curious to hear what she says…

In the meantime, I’ve heard only to allow very highly trained specialists (not just any ol’ derm or plastic surgeon) inject under your eyes because the skin is so thin, that if not done perfectly, you can see the blue filler (if I recall, it’s blue?). This is most likely why it made yours look worse.

#943

I’ve used only topicals under the eye, all of which irritate the skin. I’ve tried retinol, adapalene, peptides, niacinamide, etc. For the reasons you point out, I don’t think injections are the answer.

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#944

LaraPo, thanks for discouraging me!

After your detailed description, I think that there is no way I’ll be able to inject myself like that. At most, as I saw in one video, I would be able to use a mesoroller and then paint the product on the ‘prepared’ skin. Maybe. Not sure. Also, it seems like a lengthy endeavour.

At this point, my strategy will be to start studying this alien subject of skincare beginning with simple things like facial cosmetics. I have no hurry.

2 Likes
#945

I have never seen a blue filler. May be it exists but for what purpose? Do you have a brand name for a blue filler? I used only either transparent fillers which are HA base, like in Juvederm line, or a white filler, like in Radiesse.

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#946

It is a lengthy endeavor! It takes me about 2 hours for a full face procedure. It’s also more difficult to inject on self than on smb else.

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#947

How do you define an under eye circle? Do you mean your skin is dull and sunken or do you mean your skin looks swollen like in ppl with kidney problems (water retention)?

#948

I’ve never used filler under my eyes, but my friend who does flies to LA to see a special eye plastic surgeon a couple times per year to reduce the risk of blue showing through. I have heard it happens fairly often and many injectors won’t even do it due to the risk.

And I’m glad you asked because I couldn’t remember which product is blue, so I looked it up and was reminded it’s not the filler. It’s a common effect under the eyes when not placed well due to the thin skin… called the Tyndall effect.

Google says:
If filler under your eyes appears blue, it’s most likely due to a phenomenon called the “Tyndall effect,” which means the filler was injected too superficially under the skin, causing light to scatter and produce a bluish hue; this is especially noticeable in the thin skin under the eyes

1 Like
#949

I do have CKD but the skin is more sunken than swollen, more reddish than blue. It may be a shadow effect,

#950

If it bothers you, may be consult with a dermatologist. I don’t think you can correct it yourself.

1 Like
#951

Nah, it doesn’t bother me that much. Thanks.

#952

While skin health can be improved, ultimately the aging process doesn’t stop.

I’ve mentioned elastin previously and this part of our skin structure cannot be improved in any significant way. Without a way to improve/restore elastin we die. Not because of our skin but because of the importance of elastin in basic bodily functions that degrade along with our ever degrading elastin.

This is a very well understood issue that no one wants to talk about because there is nothing that can be done about it.

Elastin is the #1 life span limiter. It limits human lifespan to 115 - 120 years regardless of any other intervention.

It’s why you have never seen anyone over 60 without saggy skin. Regardless of their “lifestyle” and their efforts to remain young :slight_smile:

Anyone here do the “snap back” test? It’s pretty easy and very revealing. With your hand flat on a table or desk, pinch the skin on the back of your hand for 10 seconds. release the pinch and time how long it takes to flatten out. Try this with various aged people to see who’s got the most elastic skin :slight_smile: and it won’t be anyone over 60 LoL!

This is why I only read the philosophical discussions on “longevity” for entertainment.

5 Likes
#953

There is some evidence of oral minoxidil increasing elastin production.

Chronic administration of minoxidil protects elastic fibers and stimulates their neosynthesis with improvement of the aorta mechanics in mice - PubMed

Elastin is the #1 life span limiter. It limits human lifespan to 115 - 120 years regardless of any other intervention.

Do naked mole rats produce elastin? They have an excellent ecm due to continuous production of hyaluronic acid but I haven’t read anything about elastin yet. And at the age of 120, telomere length slowly starts to play a role in limiting lifespan.

This is why I only read the philosophical discussions on “longevity” for entertainment.

It’s only a matter of time until more potent medications come into existence that down- or upregulate the production of elastin and various other substances that severely limit our lifespan.

7 Likes
#954

When you do a bit more reading on how elastin is made, when that process stops and why it stops, you will better understand that “up-regulating” elastin production is a non-starter. Why? because the system that makes elastin stops functioning in your early teens and never produces new elastin for the rest of your life.

The body typically stops producing elastin after puberty. Elastin is a protein that gives skin and other tissues elasticity and recoil. It’s also a key component of many organs that need elasticity, like blood vessels.

Here are some other facts about elastin:

  • Production

Most elastin is formed before birth, and production stops during puberty.

  • Half-life

Elastin has a long half-life of about 70 years, so it should last a lifetime in most healthy people.

  • Degradation

Elastin degrades slowly in healthy tissues, but it can be damaged by age and environmental factors.

  • Calcification

As it ages, elastin calcifies or hardens, which makes it harder for skin to stretch and return to its original shape.

  • Genetic diseases

Mutations in the genes that encode elastin can cause inherited elastic-fiber pathologies. Marfan syndrome is a common genetic disease associated with mutations in the fibrillin genes.

3 Likes
#955

It’s quite a generalization! I don’t have saggy skin anywhere yet. And I’m almost 70. A friend of mine who just turned 65 also doesn’t have saggy skin yet. Where did you get that information that everybody is supposed to have saggy skin after 60?

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