#1036

Beth, I gave Tremella mushroom powder a 30-day trial and noticed nothing. I’ll put the empty package in my plastic bag of supplements that do nothing (for me). Well, at this point it’s actually two kitchen-sized trash bags. When I think I’m hearing of something new I always look through the bags to make sure I haven’t tried it before. I started doing that when I discovered I had about 5 different bottles of melatonin stashed around the house.

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#1037

I laughed about you checking your bag of shame to make sure you haven’t already tried something you are thinking about buying. It’s even funnier to me because I once excitedly ordered something someone was talking about here and it turned out I already had a mostly full bottle!

So, on tremella… I was so excited and committed, I bought 3 bottles on during the Black Friday sale. At the same time, I also ordered hyaluronic acid for the first time. I’ve been taking them both daily for two months.

I can’t be positive, but a couple weeks ago I felt like something I’m taking is making my skin slightly better. In that time, I also started alpha klotho and saw one person comment they see a difference in their skin when they take it, so?? What I plan to do is use it up and continue with klotho and hyaluronic acid and if I see my skin going downhill, then I’ll know it was tremella.

Because there is an off chance it’s working, and mushrooms are supposedly good for us anyway, maybe you should go dig it out of the bag o’ shame and use it up. Maybe give it a full 2 months?

@Keith, I think I saw the comment on skin in your group, thoughts?

1 Like
#1038

Breakthrough Drug Reverses Aging in Skin, Speeds Up Healing

Topical ABT-263 effectively reduced several senescence markers in aged skin, preparing it for improved wound healing.

Researchers from Boston University’s School of Medicine have identified a promising treatment that could improve wound healing in aging skin. Their study, published in the journal Aging, reveals that the drug ABT-263 can significantly accelerate skin repair by eliminating old, damaged cells known as senescent cells.

https://www.eurekalert.org/news-releases/1072523

https://scitechdaily.com/breakthrough-drug-reverses-aging-in-skin-speeds-up-healing/

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#1039

Especially impressive since the control was DMSO, which helps in wound healing better than anything else I know of.

Confusing in that I thought senescent cells helped in wound healing.

1 Like
#1040

Also known as navitoclax:
Safety and efficacy of navitoclax, a BCL-2 and BCL-XL inhibitor, in patients with relapsed or refractory lymphoid malignancies: results from a phase 2a study

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#1041

There is an old saying, too much of a “good” thing…

Senescent cells are a 2 edged sword. When you need them, you need them and your body will make them on demand. Since they are “immortal”, the ones that do not go away when they have done their initial job will be harmful as they secrete SASP. Clearing out senescent cells that are no longer contributing to tissue remodelling is beneficial.

By immortal it means senescent cells do not die on their own. They can be “killed” but they must be cleared either by a healthy immune system, which starts failing in this function around 40, or you do other things to clear them.

Since zombie cells are immortal, they accumulate over time. Especially as we age where it looks like this accumulation starts to go logarithmic. With each “injury” our body makes more senescent cells and on top of that, 4 components of SASP are recruiting signals that turn nearby healthy cells into senescent cells.

The more senescent cells you have, the more you get and the more that accumulate.

By the time a person dies at 70+, it is estimated that 15% to 18% of our cells are senescent. Autopsies and biopsies of damaged vertebral disks show that 25% or more of a damaged disk is typically made up of senescent cells in people over 70.

The Threshold Theory of Senescence speaks to this conundrum.

threshold_theory_of_senescence

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#1042

Plenty of places selling it too (but most seem to have controls from stopping it going into the hands of regular folk).

2 Likes
#1043

Do you buy the 3Dose syringes from Mesoram? Do those needles fit a luer lock syringe?

#1044

I crush up 1mg of rapamycin into my Ret-A and micro needle it into my face. Yes I’m a maniac but dam it works.

3 Likes
#1045

I grow probiotics and put them on my skin with amazing results.

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#1046

I’m 62 and my skin is beautiful … no sagging yet!

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#1047

Tell us more about growing probiotics and the results you have. Do they take away fine lines or lighten skin?

1 Like
#1048

I assume you micro needle and then spread the tret/rapa mix onto your freshly needled face?

#1049

No, I mix the rapamycin into the Ret-A, then liberally spread it on my face, chest, hands and forearms. Then I use a small microneedle roller and roll it into my skin … please recall I said I’m a maniac. The first time it did it … it caused a lot of red raised skin. By the third time my skin was not so irritated. I’ve been doing it weekly … though I think I’m going to go to bi-weekly.

3 Likes
#1050

The probiotics are very soothing. My skin is already pretty good so its hard to tell if it is doing more. As for lightening … I’m a redhead and my skin is very fair and I don’t have age spots on my face so I have not been focused on lighten…

#1051

Hormones may be leveraged to treat and prevent signs of aging such as wrinkles and hair graying, according to a study, “Endocrine Controls of Skin Aging,” published in Endocrine Reviews .

Until now, only a limited number of hormones, mainly topical retinoids (retinol and tretinoin) and estrogen, which are typically used to treat side effects of menopause, have been used in clinical practice as anti-skin aging compounds. This study reviews a new class of hormones and their anti-aging properties.

Melatonin is especially interesting as a potential anti-skin aging substance as it is a small molecule, inexpensive, well-tolerated and a direct and indirect antioxidant as well as a regulator of mitochondrial metabolism. Some of the studied hormones, moreover, have astonishing and unexpected biological effects on skin function and hair aging, as highlighted by distinct genetic deficiency syndromes.

They also reviewed the emerging roles of additional endocrine players, including α-melanocyte-stimulating hormone (responsible for skin pigmentation), members of the hypothalamic-pituitary-thyroid axis, oxytocin, endocannabinoids (found in CBD products) and peroxisome proliferator-activated receptor modulators and found they have very promising effects, e.g. on UV-induced genotoxic stress crucially involved in the development of photoaging and pigment synthesis within skin and hair.

Paywalled Source Paper:

Markus Böhm et al, Endocrine Controls of Skin Aging, Endocrine Reviews (2025). DOI: 10.1210/endrev/bnae034 , dx.doi.org/10.1210/endrev/bnae034

8 Likes
#1052

Finally some reasonably priced topical rapamycin with added bonus - exosomes. I don’t know of any good studies on the latter but the got the cream just for rapa alone.

https://www.musely.com/cellrepairserum

  • iPSC Exosomes 250 million/bottle
  • Rapamycin 0.0125%
10 Likes
#1053

Melatonin is especially interesting as a potential anti-skin aging substance as it is a small molecule, inexpensive, well-tolerated and a direct and indirect antioxidant as well as a regulator of mitochondrial metabolism.

Makes me wonder if one could usefully (and safely) apply melatonin topically; if the molecule is small enough, with a bit of transcutol, well… that would be easy to mix up.

I myself can’t tolerate melatonin orally, except at teensy doses, but topical applications are generally thought to have localized effects. Hmm.

Anyone tried this? Any theories?

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#1054

I’m interested too and have some transcutol and powdered melatonin on hand. Thanks for asking. If I find anything useful I’ll put it in this thread.

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#1055

Per Copilot:

There are several skin penetration enhancers that can be used to improve the absorption of powdered melatonin through the skin. Here are some commonly used options:

  1. Transcutol® (diethylene glycol monoethyl ether): Known for its excellent solubilizing properties and ability to enhance skin penetration
  2. Propylene Glycol: Widely used in topical formulations
  3. Ethanol: Often used in combination with other enhancers to improve skin absorption
  4. Oleic Acid: A fatty acid that can disrupt the skin barrier and enhance the penetration of active ingredients
  5. Dimethyl Sulfoxide (DMSO): A powerful penetration enhancer that can increase the absorption of various compounds through the skin
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