#1056

I’ll try it too and report the results if any.

2 Likes
#1057

Awesome. I just found this which is older from 2012 but still seems positive although I’m not a scientist.

“Regarding clinical application, exogenous melatonin should rather be used topically than orally, since orally administered melatonin appears in rather low levels in the blood due to prominent first-pass degradation in the liver, thus limiting skin access.84 Topical application might be meaningful, since melatonin can penetrate into the stratum corneum and build there a depot due to its distinct lipophilic chemical structure.85Therefore, endogenous intracutaneous melatonin production, together with topically applied exogenous melatonin or metabolites can be expected to represent one of the most potent antioxidative defense systems against UV-induced skin aging.25,29-31”

3 Likes
#1058

I definitely want a full report!

I have been using the Elevai serum with exosomes for about a year and my skin seems to love it, but this serum with the addition of rapa is quite appealing.

1 Like
#1059

I have been using a 1% melatonin lotion on my scalp since 3 weeks without any negative reaction. (I upped the dose). I use a self made lotion with similar ingredients as Bryan Johnson, he uses 0,1% melatonin

5 Likes
#1060

Isn’t that a tiny amount? 1% and 0.5% rapamycin creams is used for facial angiofibromas,

1 Like
#1061

Please tell us the type (genus, species, and strain if it’s a unique strain) of the probiotics you’ve been using. Thank you

#1062

Just watched this interesting and informative video of Amitay Eshel, co-founder and CEO of Young Goose. I didn’t previously know some of the information, such as advantages of topical NR and NMN over NAD+ or niacinamide, for example, or that topical spermidine plus spermine and putrescine is more effective than just spermidine. Or that certain marine algae extracts were senolytic or senomorphic.

1 Like
#1063
4 Likes
#1064

Well crap, I guess Ima ordering that now.

2 Likes
#1065

Has it occurred to you that this might just be BS? Topical niacinamide has a ton of evidence and clinical studies behind it. NR and NMN do not. And a quick google search shows that this guy sells… topical NR and NMN products… what are the chances!

7 Likes
#1066

Yes - I wouldn’t rely on that site/ that company for recommendations. Did you look at their bios?

As @relaxedmeatball mentioned - Niacinamide has a lot of good science behind it for skincare, but not the other ingredients. I’d listen to some podcasts of skin care chemists who, ideally, who are reviewing the scientific literature and sharing what they are learning, not just trying to promote their products. These podcasts are reasonably good from what I can tell, skin care chemists and dermatologists:

Amitay Eshel

Amitay Eshel is an entrepreneur in the biohacking and beauty industries, with over a decade of executive experience in health, wellness, and beauty, as well as business development consulting.

As Co-founder and CEO of Young Goose and host of the Young Goose’s Biohacking Beauty podcast, Amitay drives innovation in wellness by focusing on performance optimization and skin health. A renowned speaker and wellness expert, he has been featured on various podcasts and at events like Biohacking Congress and KetoCon. Outside of work, Amitay enjoys martial arts, mindfulness, cooking, traveling, and studying history, always staying informed on the latest in health and longevity.

Anastasia Khodzhaeva

Anastasia Khodzhaeva is a biologist and biohacker currently serving as Chief Marketing Officer at Products4Problems. Graduating summa cum laude from Florida International University, she has experience in lab research on liver fibrosis and breast cancer, as well as leadership roles in health, wellness, and beauty start-ups.

2 Likes
#1067

Need to find out if they ship to the UK. Didn’t accept my mobile number as valid and no option to enter international dialling code. Not hopeful but gonna try :slight_smile:

#1068

Here’s my list of the microbes I grow and consume in mega - doses.
Microbes I grow.pdf (36.0 KB)

1 Like
#1069

Foreign nationals are allowed to see US providers especially because it’s a cash visit. You need a “doctor” visit to obtain the topical rapamycin since it’s a script. Maybe Musely doesn’t want to violate some European laws by shipping the substances.

1 Like
#1070

Dr. Green’s 1/2% Rapa in Aquaphor does the trick for me.

2 Likes
#1071

How do your grow all these microbes? I’d be interested in growing my own.

Those brands indicated get a bit expensive if one is striving for a full spectrum.

#1072

After lots of trial and errors, we are now using a water bath with an immersion heater (like for sous vide cuisine). This allows for a very precise incubation temperature control. Before that we tried yogurt makers but their temperature regulation is very poor and you can’t control it.

We make several gallons of probiotic yogurts, kefir, etc. per week with A2 protein whole milk.
For instance here we are incubating a gallon of probiotic yogurt at 39ºC (102ºF) for 36 hours (to have mostly no lactose left. Kefir is around 12~18 hours otherwise it’s too thick). My GCM shows no glucose spikes when eating yogurts and kefir made that way.

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image1920×3180 428 KB

3 Likes
#1073

I use organic half and half as my base and add a bit of organic coconut sugar to feed them. I’ve tested many food sources such as various fibers and other sugars but they grow best in coconut sugar. I add the probiotic to the mixture and put in a dehydrator that is set at 90 degrees. I leave them in the dehydrator till the yogurt sets up. I then put a couple of tablespoons in a container in the freezer and I use this as my starter for the next batch.

2 Likes
#1074

That’s exactly what I was wondering. You “seed” with commercially purchased probiotics. I was wondering why you had that list of all those probiotic companies with their product contents.

#1075

Interesting, never knew there was such a thing!!

Found some locally.