#1

I have 500 mg of high purity Rapamycin from Science.bio.
This equates to approximately 0.0176 oz a very tiny amount to handle.

(Related: Powdered Rapamycin from Science.bio)

Need

I need a way to readily work with such small amounts to prepare:

  • Topical Minoxidil + Rapamycin
  • Rapamycin face|skin cream
  • Toothpaste + Rapamycin

Transcutol?

My initial thought, dissolve Rapamycin in Transcutol to give me a volume of liquid more readily used and measured without high precision instruments.

I would, as example, want to add 10 mg of Rapamycin to a batch of any of the three use cases.
For context I currently add 10 mg to a month’s supply of toothpaste and topical Minoxidil, but currently I use Rapamycin powder from a compounding pharmacy than must have a huge percentage of fillers.

Process

The process seems straight forward as Rapamycin has a high solubility in Transcutol, (approximately 144.8 mg/mL).

To dissolve 500 mg of Rapamycin, it looks like I would need approximately 5 mL of Transcutol to achieve a concentration of 100 mg/mL and amount well below saturation.

To add 10 mg of Rapamycin to a batch, I could use 0.1 mL of the 100 mg/mL solution.

Questions & Considerations

  • Does the above make sense?
  • What about stability and compatibility with other ingredients?
  • Any concerns about Rapamycin pH and Transcutol?
  • Do Rapamycin formulations require a pH below 6 to maintain stability?

Input appreciated.

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#2

I would start with a good scale… something like this (I like the fact that its USB powered - see below):
And generally, yes - what you’re suggesting seems accurate. I don’t have time to dive in deep on your questions right now - but I think they’ve all been addressed before in these threads:

Screen Shot 2025-02-22 at 10.50.30 AM
Screen Shot 2025-02-22 at 10.50.30 AM2312×952 148 KB

#3

I think you mean 0.0176 ounces.

Its still not that much.

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#4

Yes indeed. I corrected the post.
Thanks.

#5

I’ve finally come up with my plan.

The jar in which Science.bio packages the Rapamycin will hold just over 43 ml of liquid.

I’ll start by adding about 20ml of Transcutol to dilute the Rapamycin in the Science.bio jar.

I’ll transfer the dilution to a 50ml graduated amber glass dropper bottle and top of the bottle with Transcutol.

This should give me 50 “doses” (1ml per dropper full), each containing 10 mg of Rapamycin.

Each month I’ll use 30 mg of Rapamycin (10 mg toothpaste + 10 mg hair tonic + 10 mg in face cream).

500 mg divided by 30 mg per month = 16.6 months.

Pretty easy. No scale needed.

Current plan, I’ll refrigerate the dilution of Rapamycin.

I’ve got about 2 weeks of my current batches of toothpaste and hair tonic so planning to start everything early April.

All-in-all pretty cost efficient, so I could up how much Rapamycin I use in each application.

Thoughts and suggestions appreciated.

Possibly for the future, Science.bio now has Rapamycin – Solution, 300mg (10mg/mL) at $99.00

Physical Form: Liquid, solved in EtOH (known variously as ethanol, ethyl alcohol, and grain alcohol)

More expensive than the powder, but it seems ready to go for purposes of toothpaste, hair tonic, or kin cream.

Thoughts?

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