Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibi- tors, spermidine, senolytics, probiotics, and anti-inflammatories. Multiple clinical trials have commenced to evaluate the efficacy of such agents against age-associated diseases including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases. There are reasonable expectations that drugs able to decelerate or reverse aging processes will also exert broad disease-preventing or -attenuating effects. Hence, the outcome of past, ongoing, and future disease-specific trials may pave the way to the development of new anti-aging medicines. Drugs approved for specific disease indications may subsequently be repur- posed for the treatment of organism-wide aging consequences.
Article available lower in thread.
https://www.sciencedirect.com/science/article/abs/pii/S1550413123004588
Worth a read if only I could get it. Anyone?
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Joseph, just uploaded the full article.
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Thank you! This is a big help.
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Itās a nice read. These are quality researchers. But itās a summary of summaries. Itās a good article for your friends who want to know whatās all the hubbub about longevity.
The rapamycin section was oddly limited and cautious about stuff we all know is workable from personal experience.
Oh well.
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Neo
#6
I was aware of building healhspan via probiotics but not that it actually was a longevity candidate:
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@Joseph_Lavelle where did you buy your Akkermansia probiotic? Can you post the link?
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Neo
#8
It may have been this from this group that both Peter Attia and Ben Greenfield now have recommended (and Ben may have some rebate).
Itās where I got mine from and the CEO and company do seem legit. (I have no affiliation, and am only one month into my 3 month trial period).
They have different versions
Only that strain
The combination one in their clinical trials
And a lower cost combination one
This just came up when I was finding the links for you, so perhaps they are still offering discounts directly also (perhaps even see if you can combine)
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Pendulum
This is the source. I buy the Akkermansia product. It continues to change me. For the better I think.
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Great to hear that itās working. Did you buy any of their other products as well?
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No. Not at this time. Iāve heard the founder speak a few times. Impressive. But Iām trying to stick with my āone thing at a timeā plan.
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Neo
#12
I went with the glucose control version because it was the one in the clinical trial (and that Attia was taking), but also because of the combinations of thinks for butyrate and gut lining. Itās expensive, but does feel like itās helping. I did some stool test stuff before, so will be interesting to see if anything shows up on that when I redo. (My HbA1c tends to run low, but I will have that and other basic blood work to look at also as before/after).
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