No_2
#1
I’m looking at drug interactions on Sirolimus: Uses, Interactions, Mechanism of Action | DrugBank Online and it reports “The risk or severity of adverse effects can be increased when Sirolimus is combined with Hydroxychloroquine.” But I’ve not managed to find more information online. Is any one else able to expand on this so I can better understand the risk of taking rapamycin if I someone is already on hydroxychloroquine.
Infamous paper that popularized unproven COVID-19 treatment finally retracted
Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
A 2020 paper that sparked widespread enthusiasm for hydroxychloroquine as a COVID-19 treatment was retracted today, following years of campaigning by scientists who alleged the research contained major scientific flaws and may have breached ethics regulations. The paper was pulled because of ethical concerns and methodological problems, according to a retraction notice.
The paper in the International Journal of Antimicrobial Agents (IJAA), led by Philippe Gautret of the Hospital Institute of Marseille Mediterranean Infection (IHU), claimed that treatment with hydroxychloroquine, an antimalarial drug, reduced virus levels in samples from COVID-19 patients, and that the drug was even more effective if used alongside the antibiotic azithromycin.
But scientists immediately raised concerns about the paper, noting the sample size of only 36 patients and the unusually short peer-review time: The paper was submitted on 16 March 2020 and published 4 days later. On 24 March, scientific integrity consultant Elisabeth Bik noted on her blog that six patients who were treated with hydroxychloroquine had been dropped from the study—one of whom had died, and three of whom had transferred to intensive care—which potentially skewed the results in the drug’s favor. Larger, more rigorous trials carried out later in 2020 showed hydroxychloroquine did not benefit COVID-19 patients.
https://www.science.org/content/article/infamous-paper-popularized-unproven-covid-19-treatment-finally-retracted
