#23

HBOT’s increase in free oxygen radicals would likely decrease longevity. Most of the papers with HBOT appear in cancer treatment, where the increased generation of free radicals increases the effectiveness of radiation treatment and some chemotherapy agents.

#24

Hyperbaric Oxygen Therapy Adjuvant Chemotherapy and Radiotherapy through Inhibiting Stemness in Glioblastoma.

#25
#26

Don’t think Bryan Johnson would be doing as aggressive a HBOT protocol as he is or seeing the results he is if it was known to be bad.

https://x.com/bryan_johnson/status/1861085751024484459

#27

I don’t think bj is the font of all wisdom, but HIF 1 alpha is a useful nuclear factor

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#28

Yup for sure. In his link he sites a lot of good research though to support his trial.

#29

Interesting interview. He is also an investor in HBOT clinics so he might be biased. But he explains the theoretical background and the protocoll.

Reverse Aging with Hyperbaric Oxygen Therapy - YouTube

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#30
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#31

I was considering Hyperbaric Oxygen Therapy, but this study, showing it may have negative effects on the gut biome, tipped the case against it for me, together with the fact that I get one of the goodies of HOT, immune strengthening, for a fraction of the cost and time with peptide Thymosin Alpha 1.

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#32

There is a lot of debate about the mechanism of HBOT. I purchased a liveo2.com adaptive contrast system that I can cycle between very high O2 (85+%) to very low (10%) and do this while exercising (EWOT). Seems like this will create a large hormetic effect between hypoxia and hyperoxia states.

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Extending the benefit of sleep: Oxygen increase while sleeping
#33

How long have you been using it, how often and for how long?
I ask this, if you considered in you N=1 experiment testing your telomere lenght before and after 90 days, to evaluate if the stimulus corresponding.

Fabio

#34

The key thing about HIF is that it results from a change (reduction) in partial pressure of oxygen.

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#35

just started - did get a trudianostic age test before starting so will look again in a few months

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#36

You can get faster feedback by tracking your sleep breathing rate. Lower rate means more co2 tolerance. Nasal breath while sleeping also helps.

#37

Paul, your home experiment feedback is extremely valuable, i’m cross-referencing your feedback on my other attempt to achieve a similar oxygen playground but while sleeping, it would be way interesting to come up with some data on effectiveness on telomere length (that’s a way known benefit of HBOT alternating oxygen protocol at 2ATA), but without expensive/dangerous/complicated HBOT device.

#38

Are you also tracking your VO2Max? I’d be interested in pre and post testing for that…

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#39

in a way. My Oura ring has a 6 minute walk test that provides a VO2 max number

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#40

Cross posting this thread where we’re discussing the potential benefits of hypoxia: Oxygen, hypoxia and hyperoxia

I wonder if a significant part of the benefits of HBOT might actually come from HIF activation during the return to normoxia…

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#41

I think the main benefits of HBOT arise from HIF activation. I don’t think Hyperoxia has any benefits beyond that.

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#42

The influence of CO2 on up regulation of hypoxia related genes.

“ Because nasal breathing prevents hyperventilation during exercise, it promotes an increase in the partial arterial pressure of CO2. The rise in systemic CO2 stimulates hypercapnia and permits the upregulation of hypoxia-related genes.”

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