#169

my hair was mostly white (I’m 70) and now I’m noticing more “salt and pepper”. In my beard, the increased pigmentation is much more noticeable with streaks of dark hair.

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#170

dihydroberberine vs berberine

“These results provide preliminary evidence that four doses of a 100 mg dose of dihydroberberine and 200 mg dose of dihydroberberine produce significantly greater concentrations of plasma berberine across of two-hour measurement window when compared to a 500 mg dose of berberine”

“The lack of observed changes in glucose and insulin were likely due to the short duration of supplementation and insulin responsive nature of study participants”

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#171

Anything is possible, but I really doubt the hair color has anything to do with RAPA. I actually got more white hair during 1.5 years of RAPA but that is to be expected since as you get older you get more white hair. I did however feel that taking some other supplements might have helped a bit, one of them being copper. But then again, I might have been deficient in copper, because if you have enough in your blood, I doubt it will make a difference.

#172

Just wanted to check—is that a typo?

Edit: Scratch that. I just saw your E2/E2 comment!

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#173

Ha! Yep. Not a typo. :rofl:

#174

Thanks Joseph. After a lot of research we chose Dihydroberberine (GlucoVantage) for our longevity supplement box (hopbox.life).

It’s been very well tolerated and anecdotally we’re seeing significant reductions in A1c, fasting glucose and insulin but less GI upset compared to berberine.

3 Likes
WiseAthletes podcast episode on Heart Health
#175

Here is my current list of Supplements (also take Rapamycin, Metformin, Testosterone cream, Peptide injections)

  1. EFA
  2. VIT D3 2500iu summer 10,000iu winter
  3. Lithium Orotate 10mg
  4. Whole food based Multi
  5. Greens powder
  6. Magnesium Threonate / Bisglycinate alternate
  7. NMN
  8. Quercetin
  9. Resveratrol
  10. Creatine
  11. GlyNac
  12. Low dose Tadalafil
  13. Beta Alanine
  14. Olive Oil pills
  15. Taurine.

Looks like I need to shorten the list a bit. Am I taking too many things ??

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#176

Nice list! No you do not need to shorten your list. I take about 30+ supplements. I probably do need to shorten my list. I started this thread just so we could all get an idea of what supplements we think are most important.

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#177

Instead of olive oil pills, you could just take a shot of EVOO. I mix NMN powder in it along with black pepper and tumeric. NMN powder is also a lot cheaper than pills. You can also mix Resveratrol in it as well. EVOO improves bioavailability of some fat soluble powders as it’s a fat source.

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#178

Conversely, I’ve noticed I have a couple new gray hairs in my eyebrows, I’ve decided to up my Rapa dose from 4 mg (2 years w/no side effects) to 6 mg wkly. Also, head hair is as gray as ever. @ 67 all my blood markers are stellar. Jumped on the methylation gene testing bandwagon, and discovered green tea and Quercetin are not my friends! So many rabbit holes! But worth it.

#179

Great suggestion. I usually use NMN in water to take my AM/no food pills. Since EVOO would break my fast, I’ll try it later in the day.

#180

What specific testing do you do that informed you to avoid green tea and quercetin

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#181

Both are HDAC inhibitors

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#182

John, I wish you would elaborate a little more on your responses. Many of us here do not understand the medical terminology as you do.
I am confused. Are you saying HDAC inhibition is a bad thing?

"By inhibiting HDACs, these drugs cause increased acetylation of histones, relaxing the chromatin structure and allowing more gene transcription. This can help restore normal gene expression in diseases where HDAC activity is dysregulated.

Several HDAC inhibitors are FDA approved to treat certain types of lymphoma and myeloma. They help reactivate genes that trigger cell cycle arrest, apoptosis, and differentiation in cancer cells.

HDAC inhibitors may help improve cognitive function in Alzheimer’s and other neurodegenerative diseases by enhancing synaptic plasticity and memory formation.

By regulating gene expression, HDAC inhibitors have potential as anti-inflammatory agents. They are being studied for diseases like inflammatory bowel disease."

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#183

My Naturopath ordered Methyl Detox Profile through Rupa. They checked MTHFR, MTR, MTRR, AHCY & COMT. A mutation in my COMT nutrient recommendation suggested high does of bioactive food components such as tea catechins (green & black tea, EGCG, green coffee bean extract) & Quercetin may further inhibit COMT enzyme activity. Ceased use of both & my recently developed sleep issues & low-level anxiety were remedied. Also recommended I up my magnesium OrthoMolecular Opti Mag Neuo, B’s need to be methylated, added 5-MTHF & B12. If you’re interested, I’d recommend you look into 3x4 Genetics. They do a pretty thorough deep dive on many gene Nutrigeonomics accompanied by a very helpful diet, supplements, lifestyle recommendations.

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#184

I think HDAC inhibition is a good thing.

One of the substances in royal jelly which enables the queen bee to live as long as she does is an HDAC inhibitor.

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#185

Further on this, if people would like me to do a detailed post about transcription of mRNA and HDAC inhibition I will do it as a separate topic.

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#186

Yes, please do. That would be very helpful.

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#187

As the son of a beekeeper, you definitely caught my attention with this. And, yes the queen bee lives a very long time. Regular bees live a max of 6 months (winter ones) while I remember queen bees living even 5 years (usually 3-4 years, but I think we had some that lived even longer 5-7). So yes give us as much info as possible on the subject.

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#188
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