#41

@macneu2299 Ive tagged @John_Hemming as it is his anti-aging protocol that I am trying to implement. He has written about it extensively on this forum. I am still ramping up my dosing so I do not believe I’m getting a benefit yet.

I take Pantothenic acid for LDL / apoB lowering. This was a recommendation from @desertshores. My apoB and LDL fell drastically while I was taking Pantothenic acid / vit b5. I was also newly taking rapamycin (bad for ldl) and reducing my rosuvastatin dosing to EOD (bad for ldl), so I feel confident Pantothenic acid was good for lowering my ldl/ apoB.

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#42

Thanks for posting. I think Andrew’s stack is pretty good. I’d add carnosine and lysine and get rid of the multi, just take vitamins individually as needed. Most in the multi are useless in my opinion.

#43

Everybody’s different. I look at a multivitamin as a cheap insurance policy. You might have a deficiency/a gap somewhere that you didn’t know about or even every now and then. I’ll look at carnosine and lysine - so many amino acids. And certainly at my age, I need to be sure and get enough protein as I don’t eat a lot of calories.

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#44

I hear you, but as Kevin O’Leary would say I don’t feel the love lol when I was taking it. Actually it was my very first foray into supplements about 25 years ago. I felt nothing, and to me the amounts for some crucial ones are so small, while for some others I would not need/take. I did it for couple years and as a side effect nasty one, I think it made me gain weight much easier than usual. Stoped it about 20 years ago and went for bcomplex, vit,c and couple other individual ones. I have absolutely no intention to add it to my stack.

#45

B complex is the one that I can feel but there are so many others that people talk about here…selenium, zinc, boron, molybdenum, etc. that I probably get in my diet but that changes so often, usually I eat well but sometimes I don’t. At least with a multivitamin I know I’m getting a base level. With all supplements it’s hard to know what the minimum dose is that makes a difference. Astaxanthin is a good example, the usual doses are well below the ITP, are they doing anything?

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#46

Based on my past failures, I think it’s important to only change 1 thing at a time to see if the change did anything at all, and whether it was good or bad, or both.

Soft: “Feel”, clear headedness, physical energy, exercise performance, sleep, etc
Hard: blood markers, BP, RHR, weight, HRV, etc.

I’ve decided to try GG (@desertshores found it) to see if I can feel a reduction in the muscle aches I get from my statin after my weight training. I’ll also avoid other changes until after my next blood test. I’m fitting this into my 10 limit by recategorizing my nitrate supplement as food (it has the same amount of nitrate as 5 stalks of celery).

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#47

The other thing is that I think it’s likely that most vitamins/supplements work in a synergistic way in combination with others, so that if you test one by itself you won’t get a positive result, they need to work together…GlyNac for example. It could be a reason that supplements fail the ITP when they show good results elsewhere. That’s why the concept of testing one supplement at a time (while useful) may not tell you the whole story…it might only work in combination with something else.

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#48

This is anecdotal yet practical and based on my experience. The multi is useless, because for the most part our needs are taken care of with food but there is few vitamins/aminos that if take. By themselves in HIGHER doses can produce real great effects. I know there are recommended daily doses etc but that’s not the dose that will make e difference. As an example I’ve been 17 years flu,cold,sars, covid etc free because I do 2000-4000 vit c per day plus same lysine (when flu season). When I tried at 500 daily for each(trying to find the smallest but effective dose) literally started getting the flu within a week. Then upped the dose 2000x3 daily for both and my cold/flu or whatever the hell was just disappeared within 24 hours. So, many will tell you that even 500mg of vitC is too much, yet it did nothing to ward off the virus. Ever since I’ve been using 2000-3000 maintenance daily during flu season and have never gotten sick. So the moral of the story is you need much higher doses to get true measurable results. For wellbeing alone, probably a multivitamin is ok, but knowing what I know I will never add it to my stack.

#49

Creatine
Taurine
Glycine
Melatonin
Lithium orotate
Multivitamin
Magnesium glycinate
Potassium citrate
Lactoferrin
Methylene blue
It was a stretch to come up with 10 tbh. I don’t take methylene blue or lactoferrin all the time and I tend to forget lithium quite often as well. I feel good though and I’m also taking Rapa and Deprenyl.

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#50

Your energy spark probably came from the NMN. Resveratrol won’t give that to you.

#51

@Joseph_Lavelle what is your pantothenic acid dosing regimen?

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#52

They both seem to have lots of sceptics here - maybe because of their association with David Sinclair, the great salesman. And pterostilbene may be better than resveratrol. But certainly a lot of people swear by some form of NAD precursor.

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#53

Just keep an eye on your kidneys. There is mouse data showing NMN can damage kidneys of old mice. Your blood will tell you the truth.

As for Resveratrol, it always gives me diarrhea, so I am happy to stop when I use up all my supply. I think I have a year supply left. :stuck_out_tongue:

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#54

@DeStrider i take 500 mg every morning (6 days a week).

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#55
  1. Rapa
  2. Fish Oil
  3. D3 + K2
  4. Magtein
  5. Taurine
  6. Vinpocetine
  7. Magnesium Orotate
  8. Protein Powder ( Naked Pea & Rice mixed)
  9. Homocysteine Resist (Life Extension)
  10. Ubiquinol

I’ve been taking Rapa for 10 weeks now. 6mg once a week. Very noticeable results from fish oil and protein powder. Don’t notice anything from Taurine so far. I take everything on the list plus a few more.

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#56

What brand do you prefer?

#57

Its best to read the protocol thread about citrate

B5 is a coa precursor and good for lots of things as acetyl coa is a key metabolite.

Pantethine as opposed to pantethinoic acid is non rate limited.

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#58

@John_Hemming So what dose of Pantethine or Pantethinoic acid would you recommend?

#59

I take both. Pantethine when drinking alcohol.l depending on ethanol quantities. (1, 2, 3g)

0.5g of b5 daily.

B5 is in royal jelly.

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#60

I use these as well but considered them as food. If I had to choose I would keep the protein powders and let go of some of the other items on my list.

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