Imidazoline receptor agonists (eg agmatine or other oxazolines) as an alternative to rilmenidine for reducing BP?

AlexKChen · 2024-04-27T20:05:07.291Z

en.m.wikipedia.org

Imidazoline receptor

Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three main classes of imidazoline receptor: I1 is involved in inhibition of the sympathetic nervous system to lower blood pressure, I2 has as yet uncertain functions but is implicated in several psychiatric conditions, and I3 regulates insulin secretion. As of 2017, there are three known subtypes of imidazoline receptors: I1, I2, and I3. The I1 receptor appears to be a G protein-coupled rece...

agmatine seems to produce decreases in BP

Rilmenidine is hard to get

Walter_Brown · 2024-11-12T18:54:10.561Z

Me too, looking for a good alternative.