Is Metformin a Drug for All Diseases?

RobTuck · 2024-03-01T14:40:47.700Z

Is Metformin a Drug for All Diseases.pdf (1.4 MB)

DeStrider · 2024-03-02T01:25:09.735Z

Metformin is also synergistic with Rapamycin. The two drugs enhance each others benefits while minimizing each others detriments.

RapAdmin · 2024-04-06T23:20:17.074Z

Researchers have revealed that the moderate weight loss associated with metformin is due to an “anti-hunger” molecule, known as lac-phe, which is also produced after vigorous exercise.

Study Finds – 19 Mar 24

'Anti-Hunger' Molecule In Metformin May Revolutionize Weight Loss

Researchers have revealed that the moderate weight loss associated with the diabetes medication metformin is due to an "anti-hunger" molecule, known as lac-phe.

Est. reading time: 3 minutes

en.wikipedia.org

Lac-Phe

Lactoylphenylalanine, or Lac-Phe, is a metabolite generated by intense exercise. In mice, high levels of Lac-Phe in the blood cause a decrease of food intake and in humans, its production has been shown to correlate with adipose tissue loss during an endurance exercise intervention. In mammals it is created from (S)-lactate and L-phenylalanine by the cytosol nonspecific dipeptidase (CNDP2) protein. It is classified as N-acyl-alpha-amino acid and pseudodipeptide. It has also been reported that as...

KarlT · 2024-04-08T00:51:54.067Z

So do we have a chemist here? Lac-phe doesn’t sound complicated. Could you make it and take it orally? Looks to me like it’s only injected.

Joseph · 2024-04-08T01:13:37.021Z

Already manufactured and sold on the market.

Hello Bio

Lac-Phe (N-lactoyl-phenylalanine)

Exercise induced metabolite that supresses food intake and obesity

Price: USD 87

KarlT · 2024-04-08T02:20:54.715Z

So, does it work? I don’t hear much about everyone running to their doctor to get Metformin for weight loss.

DeStrider · 2024-04-08T02:38:20.712Z

I have not lost any weight on Metformin. However, I haven’t gained much weight either.

RapAdmin · 2024-04-09T18:24:11.109Z

You’re unusual, it seems:

In a long-term study involving over 3,000 people, the average weight loss for participants who took metformin was 5.5 pounds. About one-third of those who took metformin lost at least 5% of their body weight after a year. And the longer they took it (up to 15 years), the better the results, with an average long-term loss of 6.2% of body weight

Source: Can Metformin Help with Weight Loss?.

RobTuck · 2024-04-09T18:54:56.332Z

It is typical but annoying that at lest standard deviations are not provided on these means and, as far as I can see, the referenced research is behind a paywall. A mean of 5.5 with a SD of 4.5 likely reflects an entirely different dynamic than a mean of 5.5 and a SD of 1.0.