Sunder
#1
Is using a 6-month overdue rapamycin safe?
I depends where it has been? Drugs like rapamycin maintain themselves best at lower temperatures, and with no exposure to humidity and especially light. On a quick search, sirolimus samples stored at 30 degrees C, but in light for a week had concentration loss of 5%.
So stored at modest/cool temperature always, no sunlight/humidity … I’d have no worries about 6 months or even a year post dates … but if transported in 140 degree F heat, exposed to the environment - they might not be that great on arrival.
4 Likes
Potency may be an issue, but there is no reason to believe that they would be at all harmful is there?
3 Likes
I agree, not so worried about toxicity - although I don’t know what becomes of the rapamycin that isn’t active, as to what it degrades to. It would be more of an efficacy issue.
4 Likes
I concur. For me, as long as it somehow doesn’t degrade into something metabolically toxic, I’d finish it off.
2 Likes
