#1
  • (00:00 – 01:37) GLP-1 agonists have leapt from diabetes control to broad cardio- and neuro-protection, convincing major pharma that prevention is now commercially attractive and pushing pipelines away from pure disease management.
  • (02:10 – 06:38) Phil Newman (founder/CEO, Longevity.Technology) explains how a career in disruptive-tech marketing and a 2018 article on Juvenescence led him to build the site into the leading news-and-data hub for the longevity industry, now refocusing on investor-grade analytics.
  • (07:51 – 14:32) He maps the sector’s evolution: Longevity 1.0 (today’s wearables, clinics) → 2.0 (disease prevention & organ-level age reversal in ~5–10 yrs) → 3.0 (systemic rejuvenation in 10–15 yrs).
  • (14:32 – 20:44) Standardizing aging biomarkers is “nearly there”; global longevity clinics expect harmonized diagnostics and care protocols within a year, paving the way for population-level prevention.
  • (20:44 – 28:08) Newman’s “10 Levels of Longevity” span DIY biohacking to Level 7 targeted age-reversal (e.g., Life Biosciences’ phase-2 partial reprogramming for eye disease) and organ-maintenance bridges like xenotransplantation and 3-D-printed organs.
  • (29:04 – 33:30) Big pharma and startups are forging multi-million-dollar deals to pair existing drugs (e.g., GLP-1s) with novel molecules, accelerating a pipeline of phase-2 prevention combos.
  • (33:30 – 39:13) 2024–25 funding data show larger rounds but fewer deals—capital is flowing to late-stage firms, leaving a mid-stage financing gap VCs, family offices, public markets, governments, and foundations must fill.
  • (39:45 – 44:13) Near-term scalable advances include senescence-focused therapeutics; whole-body (systemic) age reversal remains a 10-15-year target.
  • (44:13 – 47:02) Regulation is loosening: Montana’s expanded Right-to-Try law and the UK NHS’s mass reimbursement of GLP-1s signal greater openness to earlier access for promising longevity drugs.
  • (47:02 – 53:37) Newman expects living healthily to 120 to become normal within ~20 years if morbidity can be compressed; as an XPRIZE Longevity judge, he sees the competition accelerating standout anti-aging technologies.
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#2

Without the psychosocial population buy in, none of this works. Until everyone is exercising and eating right, lifespan won’t change much.

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#3

We have to start with educating general population about lifestyle changes to prolong life. It has to be taught in school, starting in early childhood. The concept of longevity has to be accepted by the majority. Unhealthy habits (smoking, drinking, drugs, excessive sugars consumption, sedentary lifestyle) have to be eliminated first. Only after healthy lifestyle becomes generally accepted norm we could implement other longevity interventions (gene therapy, etc). I don’t believe that life span will change soon. In 5-10 years it may change for the wealthy only.

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