Bicep
#99
If you chew a couple acarbose before the grapefruit your gut buddies will get the sugar from the grapefruit, and acarbose is supposed to increase MTor2. Just an idea.
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LaraPo
#100
A few years ago I overdosed on Rapa which resulted in temporary lung scarring. It was resolved though after I stopped Rapa for 4 months and then restarted on a much smaller dose. Dose is everything. Rapa is known to detrimentally affect healthy lungs. My point is that lungs of a smoker could be affected even more.
Rapamycin is used to treat certain lung conditions like lymphangioleiomyomatosis (LAM), where it helps reduce the loss of lung function¹. However, it can also cause some serious side effects, including:
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Pulmonary fibrosis (lung scarring and stiffening)
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Pneumonitis (lung inflammation)
Source: Conversation with Copilot, 6/26/2024
(1) Lung function response and side effects to rapamycin for … - Thorax. Lung function response and side effects to rapamycin for lymphangioleiomyomatosis: a prospective national cohort study | Thorax.
(2) Rapamune Side Effects: Common, Severe, Long Term - Drugs.com. Rapamune Side Effects: Common, Severe, Long Term.
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Of course, you, as usual, as seems to be your nature, reply by redirecting a conversation away from its original topic. When was the last time you even tried to contribute something meaningful and not snarky?
Having said that, would you care to match your credentials with Dr. Blagosklonny’s?
He is a cancer expert, you are not. He is a rapamycin expert, you are not.
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Hey you kids… get off my lawn. 
I can’t help it sometmes. Hahaha.
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dlkmd
#103
That sounds like a good plan BUT what is the “therapeutic range” for longevity vs transplant immune suppression.
dlkmd
#104
Hi Candleflower,
I am a PI on a rapamycin trial with ME/CFS patients. We monitor cbc/cmp/lipid panel or apoB, A1C and hs CRP. An LDL of 150 is already quite high so rapa may certainly make that worse.
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I posted about your trial on Twitter / X a few months ago. How is recruitment going? Perhaps we should cover it more here if you need more volunteers - let us know.
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Do you know of an updated summary of Blagosklonny’s stack. Here is an old tweet of his
He is an interesting counterweight to the conservative longevity scientists I usually listen to. I also think Blagosklonny is very smart and knowledgeable about Rapamycin and more.
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@Joseph_Lavelle I admire how you want to do things the natural way without many medicines and supplements. However, people have been trying that method since the dawn of mankind. You just can’t break 122 au naturel.
Rapamycin is the key to unlocking the door to longevity. However, there are medicines and supplements that complement Rapa. I’d argue for the classic deficiency treating supplements plus amino acids. After that, I’d argue for the medicines that increase lifespan and healthspan and minimize Rapa’s side effects such as an SGLT2I, Metformin, Bempedoic Acid, Ezetemibe, Telmisartan, and Acarbose.
I think those are the bare minimum although I am sure that there are others that will extend lifespan out there as well.
But of course you also need the basics of diet, exercise, sleep, etc…
Here’s hoping we all can break that 122 barrier!
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@DeStrider I think the main idea is to survive until better treatments are available, and in the meantime don’t damage yourself. Since no one knows how to implement this strategy, there is no right way to do it. We could agree and argue about many wrong ways to do it.
I don’t try to convince anyone of anything. I am here to learn from people who have an education or experience I don’t have, or just a good mind against which to sharpen my own mind.
So far so good. Thanks.
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SNK
#109
that’s a very high dose especially doing it weekly, but glad you have no sides. I’m a male 240lbs and do 5mg without anything, no side effect. When i was 5mg with GFJ I was prone to infections(mainly skin)…so I stopped GFJ.
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@Joseph_Lavelle Good point about waiting for something better. There probably will be. I hope it gets here soon.
That’s a big advantage we have over previous generations. Something better is always coming.
It’s times like these that I wish I was from a younger generation. I hope I don’t miss immortality. 
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AnUser
#111
What do you think the immune system does?
The problem is that your immune system can’t deal with a malignant cancer for whatever reason. Therefore we use chemotherapy to treat cancer. Rapamycin is a chemotherapy.
I’d argue that smoking, a known carcinogen, is probably the culprit.
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AnUser
#113
It could cause cancer by suppressing the immune system, but I don’t know.
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SNK
#114
I’m sorry to break it to you guys but I’ve heard that something better will coming for last 30 years, but to this day there is absolutely nothing better that I have seen in this area (as far as longevity goes). RAPA might be something that could help, but no one can conclude it to be the case because there hasn’t been a human yet that used Rapa for 40 years and they are in their 120’s lol. What is better however is the fact that there is way more information available for everyone so they can experiment and come up with something that might work for their health and ultimately longevity. I personally am very suspect of anything that will arbitrarily increase longevity, however I see absolutely no reason why a human being today (knowing what we know about nutrition, exercise and health) can’t tailor their lifestyle to easily live past 100, and even past 110, and that his huge considering that just 20 years ago there was literally no way one was sure they can live to 60 or 70 or 80. everyone almost had to rely on good luck to make it to vey old age(an some unknown reason why some siblings would live to 95 and others would pass at 60).
So, there you have it guys, sorry to be a party pauper but don’t quite count the eggs before the chickens came home to roost. do everything right, Aim for 110 and I have no reason to doubt that everyone can get there, and if (this is a very huge IF) something comes up in the future to increase the lifespan then we’d be very lucky. As it stands right now, I give this possibility a less than 1% chance of happening.
I do however (somewhere in a corner of my brain) hold a belief that the way nature works is that it creates its own systems to adjust to changes. and that is to say in today society which is consumed with instant gratification to the detriment of future indulgences (i.e. not having enough kids) then for reasons unknown to us/man all of the sudden we could see/witness people starting to live and be productive well beyond the age 100. I base this on the fact that I remember when I was a kid 50 years ago, we would consider anyone past about 50 as old, and this is not just because we knew they were 50 but they actually did look the part of being old. I checked the pictures of some of historical figures at my age, and I can literally say they all looked like they were my father’s age compared to my pics. who the hell knows maybe something in the air today that is making people look and feel younger (CO2 anybody? hahaa had to include this zinger, sorry
)
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@SNK One of my favorite Star Trek lines from Captain Picard is:
“Everything is impossible until it isn’t”
Keep working hard toward your best outcome. Hope for the best. Be ready for anything.
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SNK
#116
yeah I hear you man, and all (what you wrote) is good and makes sense, but (unfortunately there’s always a but) if you look at where we are scientifically in last 200 years (i.e. fighting with daggers to now having drones do a solders job, or having to go on mountain top and yell your lungs out in hopes next house or village will hear you (your message) to looking in real time at a person while you speak to them 10,000 miles away from you. However, when it comes to longevity very little in terms of the max lifespan. My great, great, grandfather passed away at 105 in 1910 and I’d be very lucky if I can match his long life. Actually, I know I can match it, (baring some unforeseen event) but damn it, I should at least be looking for 150 easy by now.
I know people make the excuse that oh there was never much attention in the field and this and that but trust me those bastards that count their pennies in trillions would want nothing more than to add couple years here and there to their lifespan, yet they are dropping like flies in their 60’s, 70’s and 80’s just like the rest of us commoners lol.
Having said that I do think that we are at a good place right now. I remember 35 years ago when our employer gave us booklets on how to detect early a heart attack. Reading through it, it scared the living daylights out us (me and my bodies) that it could happen at any age, at any time and at any of us. Knowing what I know today if my employer handed me one today, I would simply throw it in garbage without even reading one word of it. If you think of it, that is a pretty big advancement on the Healthspan front (meaning i can control my own Healthspan), but NOT much at all in the max life span front. Will wait and see.
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GF is GrapefruitJuice which enhances the bioavailable dose approximately 4-5fold. I started taking both Metformin (for age prevention) and the Statin (because my cholesterol levels were a little elevated) before starting with Rapamycin. Now my values are perfect even with a relatively high weekly dose. Did you try LDN (low dose naltrexone) against the fatigue?
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I am taking the risk of the higher dose because I hope to also influence a T-Cell mediated autoimmune disease (FFA-Frontal Fibrosing Alopecia). Therefore I need a certain immunosuppressive Effect. As long as I have no significant sides I‘ll keep the dose or even increase slightly more.
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