See my earlier post a few messages up. It’s in the full prescribing info for Nexlizet. About a doubled relative risk for UTI for the combo of ezetimibe+bempedoic acid.

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£35 for 60 caps of 600mg in the UK. You take them before or just after meals, correct? That would make them my most expensive addition. Definitely interested in making an experiment if I can’t get my lipids low enough by other means. I recently upped my Rosuvastatin from 5mg to 10mg daily and some strength exercises have definitely felt a bit harder for me. Something has felt a little off since starting the statin and after increasing the dose I noticed further changes so I will have to stop them at some point to see what’s up. Be nice to have another option. I’m already taking Brillo EZ with no issues.

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Rosuvastatin is just that way for some. I tried 5mg and the aches over night were not nice. I switch to pitavastatin and hardly notice anything. I take 2g black seed oil / day too, and with the pitavastatin my LDL-P dropped from 1400 to 1000 in 3 months. ApoB before was around 120 so Im guessing it’s hovering around the 90 mark right now. I’ll get ApoB tested in a couple more months.

Side effects with statins might be because they drop the CoQ10 levels but I dont think there’s any solid evidence out there. Worth trying as it’s fairly cheap. I take it for other reasons as I have a snp that requires more in the diet and it helps with my food intolerances for some reason.

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I’ve surprisingly had fewer side effects on 40mg atorvastatin than on 10mg rosuvastatin so I’m not really sure it really comes down to CoQ10 inhibition. In any case I will be supplementing with low dose ubiquinol once a week just in case.

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I’ve developed various food intolerances over the years due to constant childhood use of antibiotics. I also struggle with a pretty severe histamine intolerance to certain foods, drinks, or supplements. It took me years of meticulous diary-keeping to understand the basics, and I still have to tread carefully and keep detailed notes. Recently, I heard about CoQ10 on a podcast and its potential benefits for people with histamine intolerance and MCAS, which apparently affects about 20% of the population in varying degrees.

Why do you take black seed oil? I have some and occasionally take a spoonful whenever I feel like it because it’s pleasant and seems to give me a boost. I’ll definitely give it a more consistent try and will also look into pitavastatin. I guess I should experiment with different brands of statins until I find one that works. They’re so cost-effective that it’s worth the hassle.

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Is Ubiquinol a viable alternative to CoQ10 for alleviating symptoms caused by statins? I’m not well-versed in this area.

The side effects associated with statins might be why many people are skeptical. If a medication can significantly reduce my already limited ability to exercise, it raises concerns about other possible effects and whether the benefits truly outweigh the rewards.

For now, I’m inclined to stick with it, considering the safety data. But I’m always on the lookout for alternatives that could let me continue making progress without the sporadic bouts of weakness rosuvastatin seems to induce. Pantethine seems like it could be that alternative, though it’s frustratingly expensive. I think I’ll try out pitavastatin and some others first.

I’d just like to say, thanks to the insights shared on this forum, I’ve become acutely aware of the importance of lipids and ApoB, especially after finding out my APOE4/4 status via 23andme. My father survived a major heart attack at 60 and wasn’t the same after. Now we have the chance to eliminate a once invisible risk factor simply by popping a few pills and making some minor lifestyle adjustments. It’s crucial to be proactive for me as 4/4.

Most of my close musician friends, however, who have been lifelong drinkers and smokers, seem indifferent about their health—a typical trait in that line of work. Now in our 40s, I find it astonishing how many still disregard their well-being, thinking there’s nothing they can do to improve their outcomes. Mentioning my health efforts often becomes a bit of a joke for them. Luckily, a few of us take it seriously and learn from each other, hoping others will follow. It is hard to leave the allure of a more hedonistic lifestyle you’ve been used to, And nicotine is a bitch. Ultimately it’s more rewarding to do so, and I feel so much better before i got really sick.

Discovering my APOE 4/4 status through 23andMe was a wake-up call, changing my outlook significantly, though I had to navigate the subsequent research into what it all meant on my own. My GP was disinterested, offering no guidance even when my lipid levels were alarmingly high. It seems the NHS are great for some things but fall short in preventative medicine, pushing me to take matters into my own hands and source medications from abroad (Thank you, Rapamycin.news and Jagdish Nikose).

Apologies for the long post. For some reason, I just kept writing. It’s been a rough ride with a chronic condition like type 2 trigeminal neuralgia, enduring four years of relentless facial pain. Here’s hoping for a resolution soon with the planned surgery.

This is a great forum. I’ve never come across one that didn’t include many insecure individuals entrenched in their own opinions and poisoning the well with bad faith and illogical arguments. This group has very well-informed team members, researchers, and experts working together to find the best solutions in an amicable atmosphere so let’s keep it that way. It’s great for someone like me who is learning but does not have a scientific background but wants to learn from the actual science, not from the noise on social media or bad science journalism for clicks.

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Ubiquinol is just a more bioavailable version of ubiquinone/CoQ10. Neither really has strong evidence going for it in clinical trials but my rationale is that the body creates like 0.5-1mg per day, statins may affect that production so I’ll be supplementing with 20mg a week which averages out to ~3mg a day.

If a medication can significantly reduce my already limited ability to exercise, it raises concerns about other possible effects and whether the benefits truly outweigh the rewards.

CoQ10 supplementation has weak evidence behind it in both humans and mice while statins, especially the stronger ones, do show significant all-cause mortality reductions. Given that information, it seems like a no-brainer to me to take statins if your LDL-C is above 70mg/dL and supplement CoQ10 just in case.

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I don’t think it’s necessary, you can try it if you get side effects, but before that you should probably switch statins or other drugs, but this is gate keeping statins otherwise and making it complicated (have to monitor liver values before and after starting statins though, and stopping at muscle pain).

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I take Pantetethine every day right before meals.
It can take up to two months to show its full effect, so I would try a bottle and get blood work done at the end of 60 days

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I agree, It makes perfect sense to take statins, but if I confirm that they continue to sap my strength and I can achieve my health goals through other means, I’ll explore those options. In the meantime, I hope to find a statin that doesn’t cause this weakness. Fortunately, for now, I don’t have to worry about cramps, but I’m not training heavy so maybe that’s why.

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Thanks. So that’s two doses of 600mg per day. £35 month. Expensive compared to other options. Seems as though NOW doesn’t have much competition either. I think you’re right. if I’m going to try it I should get blood work done to be sure. Did you track the effect it had on you?

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If you have statin side effects then the easiest/cheapest option is to try other statins. And yes include ezetimibe and keep the doses as low as possible to achieve your goals. Next step to try is adding CoQ10 but it’s very poorly absorbed so be sure to get a more bioavailable form (like Ubiquinol). The thing that works even better than CoQ10 is GG, Geranylgeraniol but it costs more and is a little harder to find. The other option is to switch from a statin to the combination of bempedoic acid and ezetimibe from India (for cost). So just keep experimenting til you get rid of the negative side effects but it’s doable. And the final option if nothing else worked is to use a PCSK9 inhibitor, but more expensive and it’s an injection (once or twice a month).

https://americanrivernutrition.com/products/gg-gold/

https://www.amazon.com/Designs-Health-Annatto-GG-300-Geranylgeraniol/dp/B0CM6NVRYX

I’m still taking pantethine but even after 2 months I haven’t seen much change in bloodtests.

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Yes, I have blood work done approx. every 30 days. I saw a significant drop of about 15% in about 30 days. I am currently taking 600 mg of Now Pantethine once a day.
Most of the studies found a significant drop with just 600 mg/daily.

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https://uk.iherb.com/pr/jarrow-formulas-pantethine-450-mg-60-softgels/121

A bit cheaper though only 450mg.

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One way that I’d probably do it before adding a statin is to test for my baseline level of coQ10

And then retest after starting the statin / coQ10 and calibrate it from there over time with some further testing

CoQ10 | Blood Test - Life Extension?

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Have you seen this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278592/ ( Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study):

“Recent studies have shown that Vanin‐1 cleaves pantetheine into vitamin B5 and cysteamine, the latter of which increases inflammation… This study found that higher vitamin B5 levels were associated with increased risk of all‐cause mortality among Chinese patients with hypertension.”

I was also very optimistic about Pantethine, but the pathways involved do not look particularly promising for longevity.

I am currently considering bempedoic acid for decreasing LDL (current level 92 mg/dl). I would take it intermittently (once every two to three days). Do anyone have any experience with such a regimen?

I am still looking for options to increase HDL (currently 39 mg/dl). Do anyone have any recommendations? Niacin and Pantethine are not options for me.

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I’ve only taken Bempedoic Acid and Ezetemibe daily. However I take BA at night and Ezetemibe in the morning. However my results are similar to my father’s who takes a combined pill in the morning.

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I suffered with histamine intolerance and MCAS for years since about age 30. I also think due to flagrant use of antibiotics growing up, and a genetic predisposition towards allergies. I had esophageal eosinophils >50 hpf which confirms eosinophilic esophagitis, random foods caused it, but a big trigger was all the usual high histamine foods, and those annoying mast cell activators like banana’s and avocados. Basically all the healthy stuff caused really bad symptoms. I had a stricture in my esophagus that required stenting. Eventually I got on a couple different biologics for it, starting with fasenra, and then later dupixent, which is now fda approved for EOE. But in the interim I was trying everything, and taking CoQ10 before known problem foods, essentially cured it, I was shocked how it was just gone… So I’ve basically been on a mix of dupixent and coq10 to manage it and now have normal biopsy in my esophagus and very minimal dysphagia. When it was at its worst I wouldnt wish it on anyone, so good luck and I hope some of this helps guide you in your quest for normality.

Regarding black seed oil, I take it for it’s potent ability to reduce LDL. Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials - PubMed

It also has myriad other positive effects, and I generally feel better when I take it. Healthline (I know, I know) has a good overview. I take this version here: Black Seed Oil 2000mg | 120 Softgels

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Black Seed oil :smiley: lol. This stuff is seriously underrated and basically unknown. It’s really good stuff and does help raise HDL in some cases.

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AIUI it gives a route into Seratonin which then feeds into Melatonin.

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