Pantothenic acid (vitamin B5) and Pantethine are two different things.
Pantothenic acid does not lower cholesterol, Pantethine does.
“Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non‐HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple‐blinded placebo and diet‐controlled investigation”
“https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942300/”
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There’s no reason to focus on raising HDL, since existing research is only correlational. Experimental studies show no effect on outcomes when raising HDL. I just focus on lowering LDL/ApoB (and Lp(a) if elevated, to whatever extent possible given current limitations).
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Hmmm… thank you for this opinion. Somehow I thought, that HDL above 50/60 might be good preventative measure. Have to look at studies once again.
Looks interesting. Are you taking it intermittently or constantly, which dosage? Any n=1 results on HDL/LDL out of blood works?
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Pantethine is not the same as vitamin B5 (pantothenic acid), but it is derived from it and shares some similarities in function.
Both pantethine and pantothenic acid are involved in the synthesis of CoA, which is essential for various metabolic processes.
However, pantethine is believed to have additional effects on cholesterol metabolism and inflammation due to its unique structure and properties.
Pantethine is often used as a dietary supplement for lowering cholesterol levels, while pantothenic acid supplements are primarily used to prevent or treat deficiencies.
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The body creates pantethine as part of creating coenzyme A. The advantage of pantethine compared to pantothenic acid is avoiding rate limits.
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Rick
#47
CoQ10 or Ubiquinol are large molecules and aren’t well absorbed. I’m on Atorvastatin and they did nothing for me. GG works much better in my opinion. More energy and prevents muscle breakdown. Statins inhibit GG which is required to make many necessary molecules.
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LaraPo
#48
An update on Benedict acid and UTIs: my cardiologist emailed me today to stop taking bempedoic acid after he finally learnt that I developed a UTI. He said that bempedoic acid in some rare cases does contribute to a UTI development (I figured it out a week ago, but thank you doc for a timely reply 
)
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Neo
#49
What does want you to do instead?
LaraPo
#50
Continue rosuvastatin and ezetimibe and start Repatha.
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Jazzy
#51
What do you mean add a PCSK9 inhibitor and take care of blood pressure and blood sugar? Does a PCSK9 inhibitor raise those?
One should address multiple risk factors in order to bring risk as low as possible.
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Is your insurance paying for that? I have no idea how much blood work my insurance will cover.
It’s a combo. My insurance pays for most blood work every 3 months now that I am old and in the care of a primary physician specializing in geriatrics.
For the rest that isn’t covered, I use Ulta
Though Marek might be cheaper for such things as rapamycin testing.
Prices of Pantethine vary widely or should say wildly. On the noted manufacturers website they list NA suppliers.
Pantesin®; Daiichi Fine Chemical Co
Rick
#59
Geranylgeraniol is sold as a supplement to replenish reduced amounts from aging or inhibited by statins.
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