Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism

John_Hemming · 2025-05-13T17:06:41.941Z

An interesting paper that finds (some) infection increases mitochondrial DNA copy number in the mitochondria without increasing mitochondrial number in the cell.

bioRxiv – 13 May 25

Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism

As large consumers of cellular metabolites, mitochondria are positioned to compete with invading microbes for the nutrients they require to grow. Yet, little is known of whether cells weaponize mitochondrial metabolism during infection. We found that...