This is an interesting paper, but I think it misses the key question which is that as to what extent metabolism-driven chromatin changes affect gene expression.
It also I think minimises the significance of acetylation, being perhaps more interested in acylation more generally.
Note: An acyl group is a functional group which contains an oxygen atom double bonded to a carbon atom. This includes acetyl which has two carbon atoms, but also proprionyl (3 carbons), butanyl (4) and lots of others. Hence acetylation is a process which is a form of acylation. The enzymes that acetylate things tend also to be able to handle other acyl groups.
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