#1

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00328-6

The article from Cell Metabolism (published July 29, 2025) reports that a molecule produced by gut bacteria can enter the bloodstream and promote excess glucose and fat production in the liver . Researchers found that by “trapping” this molecule in the gut—preventing it from reaching the liver—they achieved significant improvements in blood sugar regulation and reduced fatty liver disease in obese mice

Key points:

  • Gut microbe-derived molecules can escape into the bloodstream, disrupting liver metabolism and exacerbating conditions like type 2 diabetes and fatty liver disease

  • The study’s intervention effectively improved blood glucose control and reduced liver fat accumulation in animal models

  • This discovery opens the possibility of new therapies targeting gut microbial metabolites to treat metabolic diseases

The study offers a “new twist on a classic metabolic pathway” and highlights the importance of interactions between gut microbiota and host metabolism in the development of metabolic disorders

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#2

Is there any epidemiological studies in humans for molecules like this? I would take evidence solely based on mice or animal studies with a grain of salt.

#3

I haven’t seen any. As the authors mention, they describe a proof-of-principal study perhaps shedding further light on microbiota indirect influence on blood glucose. In mice, as you say.

I probably should have tacked the above post on to the end of this one, " https://mmabrasil.localizer.co/t/the-world-s-first-lactic-acid-metabolizer-making-fatigue-obsolete/15335 ", as it provides some context to the L-Lactate vs. D-Lactate influence on blood glucose.