#1
4 Likes
#2

Unfortunately I can’t get at the story due to a paywall. Anyone have access and can post the story?

#3

I think you can use (https://archive.ph/) to get past the paywall… works here

2 Likes
#4

It opened just fine without paywall for me. A brilliantly written article!
https___www.scientificamerican.PDF (7.0 MB)

3 Likes
#5

Ok. I agree with the article. How do we upgrade our motherboards effectively? (Beyond exercise, sleep, not smoking, etc…)

1 Like
#6

Mitohormesis promotes mitophagy where in unhealthy mitochondria are eliminated and best ones survive.
best ways to achieve hormetic stress

Hormetic stress involves controlled exposure to mild stressors that trigger beneficial biological adaptations. Here are the most effective methods to achieve it, supported by scientific evidence:

1. Temperature Exposure

  • Cold Therapy: Brief cold exposure (e.g., ice baths, cold showers) activates heat shock proteins, boosts metabolism, and enhances resilience[1][5][9].
  • Heat Therapy: Regular sauna use or hot baths improve cardiovascular health, reduce oxidative stress, and may extend lifespan[1][6][9].

2. Exercise

  • High-Intensity Interval Training (HIIT): Short bursts of intense exercise improve mitochondrial function, insulin sensitivity, and stress resilience[6][8][10].
  • Strength Training: Builds muscle, enhances metabolic health, and activates longevity pathways[8][9].

3. Dietary Interventions

  • Intermittent Fasting: A 12–16 hour fasting window stimulates autophagy (cellular cleanup), reduces inflammation, and improves metabolic efficiency[3][8][9].
  • Calorie Restriction: Mild dietary stress without malnutrition delays aging and lowers disease risk[3][8].

4. Cognitive Challenges

  • Puzzle Games/Strategic Tasks: Activities like chess or memory games enhance cognitive function and neuroplasticity[1][8].

5. Controlled Physical Stressors

  • Hypoxic Training: Moderate altitude exposure or breath-holding exercises can improve oxygen utilization and endurance[9].

Key Benefits:

  • Increased Resilience: Cross-adaptation to multiple stressors[5][8].
  • Longevity: Activation of repair mechanisms (e.g., heat shock proteins, autophagy)[1][5][9].
  • Reduced Inflammation: Anti-inflammatory pathways and cellular health improvements[8][9].

Practical Tips:

  • Start with short durations (e.g., 1–3 minutes of cold exposure, 10–20 minutes of sauna).
  • Combine methods (e.g., morning cold plunge + evening sauna) for synergistic effects[1][6][9].
  • Prioritize recovery to avoid overstress[6][10].

By balancing stress and recovery, these methods enhance physical and mental performance while promoting long-term health.

Citations:
[1] Hormesis: The Good Type of Stress - Ice Barrel Hormesis: The Good Type of Stress – Ice Barrel
[2] Hormetic Stress: Why This Form of Stress Can Actually Be Good for … Hormetic Stress: Why This Form of Stress Can Actually Be Good for You
[3] Beneficial effects of mild stress (hormetic effects): dietary restriction … Beneficial effects of mild stress (hormetic effects): dietary restriction and health - PubMed
[4] Hormesis Can and Does Work in Humans - PMC - PubMed Central Hormesis Can and Does Work in Humans - PMC
[5] Hormetic Stress: Benefits of Eustress vs. Distress - Plunge https://plunge.com/blogs/blog/eustress-vs-distress
[6] Cold Showers, Hot Saunas and the New Way to Tame Stress Cold Showers, Hot Saunas and the New Way to Tame Stress - The American Institute of Stress
[7] Post-stress glucose consumption facilitates hormesis and resilience … Post-stress glucose consumption facilitates hormesis and resilience to severe stress - PMC
[8] The benefits of hormetic stress | Total Health The benefits of hormetic stress | Total Health
[9] How to Activate Your Longevity Genes with Hormesis How to Activate Your Longevity Genes with Hormesis – Mark Hyman, MD
[10] Microdosing Your Body With Hormetic Stress (to Beat Stress) Microdosing Your Body With Hormetic Stress (to Beat Stress) – Clean Market NYC

2 Likes
#7

Remember the vid interview of Dr. Mark Tarnopolsky linked by John Hemming?

Below is a link to the writeup on the supplements.

3 Likes
#8

Another vid interview of Dr. Mark Tarnopolsky.

1:29

The mitochondria have this little piece of circular DNA which is called mitochondrial DNA which is inherited from our Moms.

2:08

For example as we get older our mitochondria don’t work and our muscles get smaller. And there’s a reasonabel relationship between mitochondrial dysfunction and thin muscles, and that’s probably the easiest way of thinking about mitochondria not working, and a consequence that affects all of us as we get older, called sarcopenia, which is a loss of muscle.

2:35

Wel it’s very clear that mitochondria respond to stimuli. And the main stimulus for increasing mitochondrial mass is exercise.

2:49

We’re all born with different mitochondria. We have different mitochondrial DNA from our parents, well our Moms, and we, from the both of our parents, the rest of it is built. So our mitochondria are slightly different in their efficiency just from natural genetics. But we can change that through exercise. For example, in skeletal muscle if we are sedentary, about 2% of our total mass in mitochondria, and we’ve done studies that after three months of training, we can bring that up to 4%. And it’s different in different tissues. For example, in heart, almost 20% of the mass is mitochondria. And other tissues like skin, it’s very very low. But they are important in every tissue. And when they don’t work well, we can see the manifestations from heart not working well, to skeletal muscles getting thin, graying of hair, cataracts, or cognitive decline, are all, to a large extent, or at least, to some extent, related to mitochondrial dysfunction.

4:24

Their lactic acid, which is a reflection that the mitochondria is not working, is very high…

5:57 Signs of mitochondrial decline

VO2 max
cataracts
Almost everyone, when you get to your 75th birthday, you’re gonna get some degree of cataracts.
High frequency hearing ability

8:20

What kinds of exercises really move the needle. Is it high intensity, is it weights, or is it blend?

I mean the very traditional answer to that is that endurance exercise is the main stimulus to increase mitochondria. And there’s no question that that’s been so well-documented by innumerable individuals for the last 40 50 years. And that is absolutely true, whether it’s cycling, running, rowing, whatever it might be …

8:58
In several of our studies, it’s very well documented, we can double mitochondrial mass in about three months of endurance exercise.

9:28 HIIT can result in similar biogenesis.

Will transcribe more later. Work beckons.

4 Likes
#9

In my view and opinion one of the leaders in mitochondria research is Nick Lane

One of his presentations

“Thoughts on ageing mitochondria.”
Professor Nick Lane
University College London (UCL).

3 Likes
#10

The entire transcript.

# Mitochondrial Mastery with Dr. Ma.md.pdf (260.3 KB)

2 Likes
#11

I’m going to be trying a couple of new to me things for mito health soon.

ARA 290
https://www.researchgate.net/publication/262796221_The_erythropoietin_analog_ARA_290_for_treatment_of_sarcoidosis-induced_chronic_neuropathic_pain

Elamipritide - SS 31
https://www.sciencedirect.com/topics/medicine-and-dentistry/elamipretide

1 Like
#12

What will your dosage of ss31 be? The dosage (40mg daily ) and the price have me thinking I would rather suffer aerobically…

1 Like
#13

Nick Lane is amazing…i have read most of his books. Loved the ones on Mitochondria specially. This Video is definitely a treat with new insights into mitochindrial electromagnetic fields and the postulate of EMF communcations between mitochondria and plasma membrane!!
If you ask particle physcists, 98 % or so of us is energy field and only 2% is matter!
Really fascinating!!

Thanks for sharing.

#14

https://x.com/jalam1001/status/1931031739150827946

#15

Anyone have experience adding ss-31 to a rapa protocol, or does anyone have insight regarding any contraindications?
I will soon add ss-31.
Thanks

#16

The functional dose used in human trials for SS-31 is quite high and as many peptides and compounds are, it’s often dosed by body weight.

Some trials they use an IV drip over a 2 hour period.

The dose is for the desired results is anywhere from 20mg to 40mg per day SubQ, usually divided into 2 doses per day.

Anything less than that and you are probably wasting your money.

40mg trial
https://www.sciencedirect.com/science/article/pii/S1098360024000716

60mg trial

I’m going to start Monday with 10mg twice daily. I bought a gram to do this experiment

1 Like
#17

I’m going to try 20mg divided into 2 daily doses of 10mg for a month, starting Monday Aug 11.

That’s not as high a dose as used in some of the long term trials (so my concerns are low) but even at this dose there appears to be some significant benefits.

1 Like
#18

I do a couple cycles a year at 40mg daily for 10 days. The best price I could find is a 10 vial kit that tests out at 37mg per vial, so I actually do 37mg x 10 days for $210.

Generally feel great after a couple days and it holds for months.

I will point out, my first attempts had it exhaust me and made exercise feel very difficult. After DNA checks, I had a tons of different issues with methylation. After adding TMG and Methylated vitamins, it seems to have ameliorated this negative effect.

2 Likes
#19

That’s interesting, looking forward to trying this one.

I’ll order some TMG, just incase

#20

I have another one ASHA 091 that is also supposed to be beneficial for the mitochondria.

Anyone with any experience that this one?

https://adoa.eu/en/the-road-to-treatment-a/30-new-developments-research-asha-therapeutics