#21

Evidence of Urolithin A as geroprotector in humans.

source: x.com

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#22

Thank you for bringing the good news about Urolithin A. I’m ready to start taking it, and also, would a daily dose of 1000mg offer greater benefits?

#23

I’m not sure that’s good news. Most trials are outside the inner circle so they are no significant changes.
In particular that shows again that there are mostly no significant clinical outcomes and only in-vitro ones.

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#24

However, there is no double-blind study on whether weekly administration of rapamycin, coupled with the uncertainty of weekly administration, prolongs human lifespan or improves certain inflammatory markers.

#25

Didn’t the Mannick study at least show an improvement in immune function?

#26

Yes, one phase 2 study did, for ResTORbio, but then the FDA changed the endpoints for the phase 3 trial and that trial the drug failed.

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#27

Chris Masterjohn gives a convincing reason why we shouldn’t waste our money on Urolithin A. You have to have a twitter profile to see the entire thread.

Chris Masterjohn on X: “THE CLAIM: Four months of Mitopure Urolithin A will boost your VO2max by 14.3%, your strength by 12%, and in just 8 weeks will boost your endurance by 17%, without doing any exercise! :thinking: Since four months of Mitopure costs $500, it’s worth taking a closer look at this claim. https://t.co/qX94D5emBl” / X

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The latest worm lifespan experimentUrolithin A extended the lifespan of worms by 45%, surpassing other compounds such as rapamycin
#28

There are several brands of urolithin A in addition to Timeline. Any experience with the less expensive brands?

#29

I’m taking the capsules from get healthspan. It’s still expensive but definitely better than timeline, and I feel I can trust their quality.

Having said that, I’d love to find an even less expensive trustworthy option.

It was just last week someone here said they are sourcing it from Aeternum Urolithin A (UA) Powder – The Aeternum Company
They do 3rd party testing, so maybe this is a good source, too?
My only worry, for me, is that it’s a powder and I tend to be a baby about the taste of things.

#30

I have seen urolithin A brands that are liposomal. What do you think about that?

#31

I am curious about liposomal supplements as well, but I don’t know enough about the topic. My number one would be if it’s a trustworthy brand and if the ingredient inside is actually UA. It’s the only reason I’m paying more at the moment, because I don’t know who to trust.

I did just buy two different supplements from Renue By Science in thinking that my gut is potentially not very good, so perhaps getting something that supposedly absorbs better was worth a shot. I hope others who are better informed chime in!

Edit: @Bruce4654 btw, I got 3 months worth at 20%, which makes them 54.66 per month. Also, I just noticed the brand that sells the powders also sells capsules with no fillers. I see each pill contains 500mg, so if this is a quality brand (I don’t know), their capsules become very affordable.

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