FWIW: I did the DAV protocol once and it had no discernable side effects, like digestive tract upsets, etc. I noticed nothing from the experience, good or bad.
Many people take doxycycline for a very extended time with few reporting side effects.
The dose used in the DAV therapy is considered to be a low dose from what I have read.
If anyone disputes this please furnish references to papers that dispute this.
“Doxycycline is used to treat infective diseases because of its broadspectrum efficacy. High dose administration (100 or 200 mg/day) is often responsible for development of bacterial resistances and endogenous flora alterations, whereas low doses (20–40 mg/day) do not alter bacteria susceptibility to antibiotics and exert anti-inflammatory activities.”
Etc., etc. I can point to many more papers that support this view.
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AnUser
#519
It is doxycycline, azithromycin and vitamin C. Not only doxycycline…
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SNK
#520
For whatever reason I was more petrified of the AZI. Doxy and vitamin C I’m ok with for up to one week. Thanks for the info and links
Alex
#521
Another low content post. Time to block you.
Alex
#522
Thanks for this information. Contains facts and useful information.
1 Like
blsm
#524
At the end of the day we all have our own risk tolerance. I think it’s phenomenal that we can openly discuss various ideas and approaches here without being shut down. We humans tend to form camps/tribes, take sides on issues and become divided but ultimately for most people actively participating here I think we are all working towards a similar goal. It helps me personally to keep that in mind. One of the few benefits I notice about getting older is that it has helped me appreciate that there are many paths to same destination and the route I travel will always be slightly different from someone else’s path. Excuse my philosophical rambling and have a Happy Tuesday longevity enthusiast friends.
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ng0rge
#526
@AnUser , @SNK , nice to see you 2 team up against “The DAV Protocol” (…even sounds like a Nazi plot…). Reminds me of the end of “Casablanca”, where Rick and Renault walk off together…but who gets to say “round up the usual suspects!”?
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SNK
#527
An unusual duo to say the least:joy:
. I’m certain the honeymoon will end in very near future LOL
José
#528
Figure 16 from the published paper
Vitamin C vs. the DAV triple combination: a mechanistic side-by-side comparison. Left panel: When used as a single agent, Vitamin C can act as a pro-oxidant and induce mitochondrial biogenesis, driving increased mitochondrial protein synthesis and elevated ATP production. Right panel: In contrast, the DAV triple combination would preferentially inhibit the synthesis of proteins that are encoded by mitochondrial DNA (mt-DNA), leading to a strict depletion of essential protein components that are absolutely required for maintaining OXPHOS. In the absence of these required OXPHOS components, this would result in abnormal mitochondrial biogenesis and severe ATP depletion. As predicted, we observed dramatic ATP depletion experimentally. Therefore, Vitamin C amplifies the effects of Doxycycline and Azithromycin, by driving mitochondrial biogenesis, thereby diluting out the pre-existing population of mt-DNA encoded proteins. In summary, this strategy was designed to create a “rho-zero-like” phenotype. Also, since Azithromycin is an established inducer of autophagy, this approach should stimulate mitophagy, to actively eliminate defective mitochondria.
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Neo
#531
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José
#532
Professor Lisnati’s paper(the DAV paper) is from 2019
And he has the credentials and is the Head of a major lab*
And I will post it again, in my view if you understand this paper(the DAV paper), DAV Therapy is a “no-brainer”.
*The laboratory is currently(in 2022/2023) ranked number 1 in England, number 2 in the UK, and number 39 word-wide.
After seeing the effects of senolytics in the RMR and the failure of the Mayo trials, I am now quite skeptical that senolytics provide any real benefits to longevity. I’ll need more proof before I attempt DAV or any senolytic in the future.
1 Like
Adding to the DAV paper from 2019. This google patent is from 2022, somewhat updated.
1 Like
AnUser
#535
There are a numerous caveats that apply like azithromycin and those with heart problems. So it is not automatically for everyone. And requires some thinking, risk vs. reward, where the reward aspect is about a experimental petri dish, in vitro, protocol, not even in humans.
It is a sign of a cult to tell people they do not need to think much about it. As well as to shut down people when they bring up possible negative consequences of a treatment or tell others to ignore them, rather than acknowledge possible negative side effects in risk vs. reward calculation.
" something so simple or obvious that you do not need to think much about it:" definition of no-brainer.
Who may not be able to take azithromycin
Azithromycin is not suitable for some people. To make sure it’s safe for you, tell your doctor if you have:
- ever had an allergic reaction to azithromycin or any other medicine
- liver or kidney problems
- heart problems, including irregular heartbeats (arrhythmia)
- ever had diarrhoea when you have taken antibiotics before
-
myasthenia gravis – azithromycin can make the symptoms of this muscle-weakening condition worse
-
diabetes – azithromycin liquid contains sugar
2 Likes
ng0rge
#536
The Caped Crusader strikes again! Saving the world from Vitamin C and 2 common antibiotics!
“Doxycycline (Vibramycin) and azithromycin (Zithromax) are antibiotics used to treat many different types of bacterial infections. Doxycycline and azithromycin are different types of antibiotics. Doxycycline is a tetracycline antibiotic and azithromycin is a macrolide antibiotic. Side effects of doxycycline and azithromycin that are similar include diarrhea or loose stools, nausea, abdominal pain, and vomiting.”
It doesn’t say “sudden death”. This protocol seems safe enough, that if people want to try it, I don’t see a problem - of course it’s not for everybody…nothing is.
Oh, Public Notice - after @AnUser disbands this dastardly cult, he will be giving deprogramming sessions…please be patient and wait your turn.
PS - @AnUser , stop scaring @SNK
https://www.medicinenet.com/doxycycline_vibramycin_vs_azithromycin_zithromax/drug-vs.htm
2 Likes
AnUser
#537
So are you responding to what I said or what you believe I said?
You don’t like that people think, for example?
That they are common antibiotics useful in certain contexts like bacterial infections prescribed by a doctor or specialist, is different. They look into your medical history, your current medications, what infection you have, and so on…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473467/
Marcolide antibiotics like azithromycin interact with colchicine, as well.
Heart failure was more frequent in the colchicine plus a macrolide cohort (n = 402, 18.3%) vs the colchicine non-macrolide one (n = 1153, 9.1%) (p < 0.0001) and also had a higher mortality rate [(85 (3.87%) vs 289 (2.28%), p < 0.0001 macrolides vs non-macrolides cohorts, respectively].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473467/
I don’t see a mention of colchicine in this 517 post long thread, despite the orginal poster, has mentioned elsewhere that he takes colchicine or say it is a ‘no brainer’ to take it.
3 Likes
ng0rge
#538
@AnUser you are as aware as anyone else that you should check for drug interactions for anything you take. What’s your problem here?
This thread has unfortunately become useless because of the nonsense. Too bad as it started out interesting — guess I’ll have to bookmark the intervention and research it on my own.
2 Likes
AnUser
#541
You don’t think it’s inappropriate that the interaction with colchicine of all drugs, people commonly take here, apparently including the original poster, is not mentioned? (I found out now by looking at the Azithromycin wikipedia page).
