#383

Thought this was interesting, in terms of target levels. The mouse study suggests quite a high dose of the best “lysophosphatidylcholine” form of DHA: 452mg. Or double that for the next best phospholipid form (phosphatidylserine) and 7 to 17x for the non-phospholipid form - triacylglycerol DHA (TAG).

If eating sardines that would require at least 2 tins a day?

“Using the allometric scaling [50], we calculate that the human equivalent daily dose of LPC-DHA for efficient brain enrichment is about 452 mg DHA for a 70 kg person, whereas the dosage using TAG-DHA, based on the previous studies, is about 3.4 g to 8.9 g of DHA per day.”

This metabolic pathway diagram is quite neat. But it suggests that the phospholipid-bound dha in Krill oil, containing being sn2 form won’t help DHA brain levels.

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“Based on the results presented here, we conclude that the most commonly used carriers of DHA, namely TAG-DHA (as in fish oil), sn-2 DHA PC (as in krill oil) or ethyl esters (as in Lovaza®, Omacor®) do not enrich brain DHA, because they are absorbed as TAG, which is not efficiently converted to LPC-DHA in the liver”

#384

My apology in advance if this was posted before. These short trials – 8 weeks in this case – irritate me but the findings are modestly positive.

#385
#386

A new paper (pointed to by @nicknorwitzMDPhD).

Lithium orotate, not galantamine hydrochloride, memantine, or rivastigmine, is the only medication that I know of that addresses prevention, symptoms, and possible reversal of dementia progression.

“https://www.youtube.com/watch?v=Hcz0Eyp1LE4”
Lithium deficiency and the onset of Alzheimer’s disease | Nature

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#387

back on my hobby horse topic : “how much phospholipid-bound DHA is enough?”… this association (only) study I posted elsewhere suggests 4 portions of fish a week is better than 3 (the % relates to vascular brain disease in 75 year olds and is rather terrifyingly high!)

“Researchers found that among people who ate no fish, 31% had markers of severe underlying vascular brain disease, compared to 23% of those who ate three servings a week, and 18% of those who ate four or more servings of fish per week. This association between lower fish consumption and greater severity of markers of vascular brain disease was independent of any differences in brain volumes and other variables like age and sex.”

https://www.neurology.org/doi/10.1212/WNL.0000000000012916

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