#1

I’d love some feedback from the brains trust here on my longevity stack. This started out as a pre-workout, hence the ingredients focused on muscle maintenance but has since become a general longevity stack that I take even on non-workout days.

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In addition to this dose, I take these in the AM with my mix:

  • 2g krill oil
  • Multi B complex
  • Astaxanthin
  • NAC
  • Berberine (not every day)

I take 8g Rapamycin once per week (in morning) on a day that I am not working out.

I have a Nootropic mix that I also take 4 times per week (can share if anyone is interested).

I also take 10mg of Methyline Blue 4-5 times per week.

My nighttime stack:

  • 5g Glycine + 5g Collagen
  • Low dose lithium
  • 5HTP
  • Magnesium
  • L-Theanine
  • Saffron
  • 10mg melatonin (not every night)

Other background, I’m 59 and work out in a combination of HIIT and resistance training 4-5 days per week, 30 minutes per session. I do red light therapy daily (20 min) and infrared sauna 3-4 times per week (30 min, 50c).

I’ve settled on this mix after around 5 years of experimentation with various compounds, occasionally dropping things out and adding things to see the effect but this mix is what I’ve been doing for about a year and it certainly works for me.

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#2

Glycine, beta-alanine and taurine all compete for the same receptors in your body which may reduced uptake of taurine and beta-alanine. You’re probably wasting your taurine. I’d space those three out by about 3-4 hours as they compete with each other.

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#3

It will all stay in the body for many hours. Is it really so that glycine, absorbed perhaps after 3 hours, quoting your numbers, will stop taurine from being absorbed after say 5 hours, and it will land in the sewer??? Colour me doubtful.

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#4

Flush free niacin is hard on the liver, though probably not in that amount. Also it does not work as well on blood lipids. You’re better off with the flush. Start low and work up if you can’t stand it.

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#5

Yup, for this and other reasons I space out glycine and taurine. I experimented taking glycine in night along with Magtein Complex (only known formulation with significant blood brain barrier penetration) but my deep sleep was somewhat disrupted abd REM became more vivid. So, I reversed it. Now that I take Taurine and Magtein in night, i have an amazing deep sleep (almost 2 hrs!)and 2.5 hs of REM sleep. BTW, the effect of glycine on sleep tends to be hughly variable a d individual so wouldnt want to extrapolate to beyond the n=1.
I take glycine mixed with creatinine and Cacoa powder in the morning coffee. Glycine is sweet so dont need to any sweetener! It works out good for me.

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#6

@vongehr if you can’t be bothered to do your own research, then you shouldn’t be biohacking.

Intracellular β-alanine uptake relies on the same co-transporter for delivery of substances that possess a similar structure (Figure 1), such as glycine, taurine and GABA [1]. Thus it is possible β-alanine supplementation impairs, via competitive inhibition, uptake of these other substances [1,11].

https://www.mdpi.com/2072-6643/4/7/585

Another possible side effect is a decline in taurine levels. This is because beta-alanine can compete against taurine for absorption in your muscles.

But hey, it’s not the end of the world if you waste your time and effort nullifying your supplements. You do you. I share the results I find through research and it’s up to individuals if they choose to act on science or their own hunches.

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#7

Thanks, I’ve been considering upping my Creatine dose, so I will split my stack and take the Glycene later (I take it at night as well). My understanding is that Taurine aids in muscle protein synthesis and workout volume so would you say it’s better to load these pre-workout? (I always work out first thing in the morning)

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#8

Thanks, I didn’t know that. I’ve been using that because I had it on hand, I’ll substitute the non-flush in my next batch

#9

Thanks @DeStrider, as a pre-workout supplement protocol would you use Beta Alanine over Taurine? Or use both but spaced out over time?

#10

Thanks @Nick1, I’ve never considered taking Taurine at night as I thought it was a stimulant. I do get good sleep on a combination of Glycine and Collagen 1hr before bed but I’ll try adding Taurine, although I note @DeStrider’s note about Glycine & Taurine being competitive. Can’t hurt to do an experiment I guess!

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#11

@Nick1 I used to take Magnesium L-Threonate, agree it’s the best but is hella expensive and I didn’t notice a significant difference but I might give it a go next time as I need to re-order. Other tip for morning coffee is that Collagen powder almost works like milk, creates a creamy mouthfeel (if you like a white coffee).

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#12

Any views on whether it’s good to take NAC and Astaxanthin on workout days? I’ve seen research on antioxidants blunting muscle building but I’m not sure if that is a general thing that applies to these two supps.

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#13

Apparently some people are given energy by taurine and others are made sleepy.

#14

N=1 experience.
Maybe it’s just me, but I quit taking taurine before bedtime because of its diuretic effects.
If I take taurine before bedtime, I always have to get up during the night to pee, which I don’t like. I did a little research on taurine, and most papers say nothing about its diuretic effects, but it has that effect on me. I like taurine, so now I just take it in the morning.
“Taurine is involved in osmoregulation, helping balance fluids and electrolytes. Animal studies, particularly in rats, suggest it can increase urine output by promoting sodium excretion (natriuresis), which may lead to mild diuresis.”

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#15

I love the quote and helpful personal experience thank you.

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#16

I take I lt in the morning for the same reason.

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#17

Having a bad day? Then tell us why you never answered this:

"I’ve looked around a bit and didn’t see any sources that say taking 10 grams of glycine would inhibit taurine absorption significantly. Here is a slightly edited Claude response (one of the places I looked, but not the only place):

Taking 10 grams of glycine simultaneously with taurine could potentially inhibit taurine absorption to some degree, though the effect is likely to be moderate rather than severe. Here’s why:

  1. Different transporters: Glycine and taurine primarily use different sodium-dependent transporters. This reduces direct competition at the transporter level.
  2. Absorption capacity: The intestines have a large absorption capacity for amino acids. 10 grams of glycine, while a substantial dose, is unlikely to saturate all available amino acid transporters.
  3. Dose-dependent effects: While 10 grams of glycine is a relatively high dose, it’s still within the range often used in supplements. At this level, any inhibitory effect on taurine is likely to be modest." (@AlbertN July 24)

Again, you seem to forget how long food stays in the digestive track. It is still absorbed when in the rectum. Your mere insistence on grounds of a few papers saying glycine might(!) inhibit uptake (initially) does not convince. I bet you, as little as I eat, that pretty much everything in there that can be easily taken up is taken up in the more than 24 up to 36 hours that it stays in me. The Gly is long gone by then, but the Taurine still remembers??? Nonsense. So:

" if you can’t be bothered to do your own research"

Let a real, accomplished researcher tell you: Research is not finding some good sounding stuff in journals, but using your own brain to critically think about such, including of course papers, but they are all to be considered with a critical mind based in a grasp of fundamentals.

#18

Good points @vongehr I know you were replying to @DeStrider, but for me, I’ve already concluded that perhaps moving my Glycine to later in the day might work for me better. I’m already taking 4g before bed and I’m planning on adding another 3g midday with my nootropic stack. I want the Taurine and Beta Alanine early for my pre-workout stack (certainly the beta Alanine).

#19

OK. You feel that the competition is minimal and that you won’t waste any amino acids if you take them altogether. That’s your call. I’ll continue to space mine out as I don’t want to have the potential to waste taurine, and I already have a great routine where I easily space out my amino acid intake.

What can I say? I like to optimize.

(And yes, I was having a bad day, so I apologize for being a bit gruff.)

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#20

“You feel that the competition is minimal…”

No, Gly outcompetes others at the glycine receptors. It is taken up first and fast. And then the taurine has hours upon hours.

Of course, if there were additional mechanisms to be considered, such as the taurine perhaps not being absorbed in the target cells (heart, muscles) but being high in blood and thus perhaps excreted in urine (just to brainstorm something), then I would agree that spacing them out is important. Such additional information is all that I was asking for, for a better understanding (after all, I also usually take them at different times, more Gly if I ate more proteins, Taurine before exercise and in that case No Gly! I just doubt the importance of spacing them if the aim is daily supplementation.).

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