New Price Quotes for Rapamycin and Everolimus

[RapAdmin]

Here are some recent quotes I’ve gotten recently. One of the big issues with IndiaMart vendors is that most of them don’t even reply to you when you ask them questions (such as pricing) - so by having a list of companies that at least respond, we’re one step ahead and not wasting our time.

I’m considering re-ordering again soon, and I’m looking at both rapamycin and everolimus. I’m thinking it may not be a bad idea to even alternate between the two, as they are very close to each other, but have slightly different characteristics and half-lines.

Please share your pricing and information you get from vendors (even if you don’t buy from them) so we all have a better sense of the market prices people are seeing… etc.

Varun Medicals

Evermil 10 mg (Everolimus) will cost USD 75 for pack of tablets.
Kindly do revert, your reply is awaited.

Regards,
Pravin Lahoti

Varun Medicals

Apple Pharmaceuticals

Dear Sir/ Mam
Warm welcome and greetings from Apple Pharmaceuticals

Thanks for the interest shown in the product Everolimus Tablets

We are pleased to offer the price and following terms and conditions

• EVERMIL 5mg *
  Brand Name: Evermil
  Generic Name : Everolimus
  Strength : 5mg
  Pack: 10 Tablets per strip
  Company: Glenmark
  Price: $80USD for 10 tablets
• EVERMIL 10mg *
  Brand Name: Evermil
  Generic Name : Everolimus
  Strength : 10mg
  Pack: 10 Tablets per strip
  Company: Glenmark
  Price : $95USD for 10 tablets

Shipping : Indiapost, EMS
Shipping Charges: $30USD
Delivery time:10-12 working days
Payment : Bank transfer /TT/Swift transfer /Westernunion/Moneygram
Whatsapp /Viber/Mobile:+919987711567

Waiting for your feedback on the enquiry quotation, Kindly revert back as
early as possible

Thanks in advances

Best Regards
Apple Pharmaceuticals
A-706,7th Floor, Winsway Complex Building
*No.2,A-Wing Chsl, Off Police Ln, *
*Opp. Andheri Railway Station, *

NIBA Healthcare India

*Thank you for your interest in *" Everolimus Tablets " We are excited
to hear from you.

• In response to your enquiry for *" Everolimus Tablets *" *Dated
  on 08/01/2022

Please find below the detailed quote for your inquiry:-

· *Price **: 70 **USD **Per **Strip *of 10 Tablet(Evermil 5mg).

· *Price **:106.4 **USD **Per **Strip *of 10 Tablet(Evermil 10mg).

· Shipment Mode : EMS/DHL/ARAMEX

· *Packaging Details : 1 x 10 Tablets. *

· Delivery Time : 8-10 Working Days.

· *Payment Mode : Account Transfer (Wire Transfer), Telegraphic
Transfer. *

[Pestodude]

I have had very good communication (via WhatsApp) thru Niba Healthcare although they once shipped through a company called Aramex who in turn shipped thru UPS in the United States and UPS asked for a prescription. Since I didn’t have a prescription (at the time), UPS confiscated the package.

[Ozone8]

As mentioned in another post, for those willing to work with a powder and create their own capsules, check out:

rapamycin-cas-no-53123-88-9

I have ordered multiple times from them with good success. They will provide a COA on request. Based in the US, delivered by USPS Priority Mail.

[RapAdmin]

@Pestodude

they once shipped through a company called Aramex who in turn shipped thru UPS in the United States and UPS asked for a prescription

Yes - both UPS and Fedex require you have a prescription. If they ship it via IndiaPost Speedpost / EMS - you don’t need to have a prescription. They should have told you this.

[RapAdmin]

@Ozone8

for those willing to work with a powder and create their own capsules

This is interesting. I wonder if there is any difference in terms of bioavailability or half life for the powdered version of rapamycin compared to the tablets most of us use.

All the commercially available product have some special coating on the tablets, and rapamune (at least - and perhaps others) use Elan Pharma’s nanocrystal technology optimized for bioavailability (I believe).

According to Elan, NanoCrystals benefit any drug formulation. Advantages include quicker onset of action, increased dose uniformity, fewer side effects, enhanced bioavailability, improved dose proportionality, elimination of food effects, more predictable therapeutic response, targeted delivery, improved safety, and greater efficacy.

Of course, I’m a little skeptical of any information coming from a pharma company… so it would be interesting to see real data on nanocrystal rapamune vs. non-nanocrystal sirolimus formulations.

As it is right now - we don’t even know which (if any) of the generic versions of sirolimus use NanoCrystals and how much of a difference they make in terms of how the drugs work in people…

I also wonder if any versions of everolimus use nanocrystals.

Nome	Dosage	Strength	Route	Manufacturer/ Marketing	Year Approved	Year Sales Stopped	!Country
Sirolimus	Tablet	2 mg/1	Oral	Dr. Reddy’s Laboratories Limited	2014-10-27	Not Applicable
Sirolimus	Tablet, film coated	0.5 mg/1	Oral	Glenmark Pharmaceuticals Inc., USA	2020-10-16	Not Applicable
Sirolimus	Tablet, film coated	2 mg/1	Oral	Cadila Healthcare Limited	2014-01-07	2014-01-03
Sirolimus	Tablet	0.5 mg/1	Oral	Ascend Laboratories, LLC	2021-03-13	Not Applicable
Sirolimus	Solution	1 mg/1mL	Oral	Novitium Pharma Llc	2019-05-21	Not Applicable
Sirolimus	Tablet, film coated	1 mg/1	Oral	Major Pharmaceuticals	2020-10-16	Not Applicable
Sirolimus	Tablet	1 mg/1	Oral	American Health Packaging	2015-11-05	Not Applicable
Sirolimus	Tablet, film coated	2 mg/1	Oral	Zydus Pharmaceuticals (USA) Inc.	2014-01-07	2014-01-03
Sirolimus	Tablet, film coated	2 mg/1	Oral	NorthStar Rx LLC	2021-10-18	Not Applicable
Sirolimus	Tablet, sugar coated	2 mg/1	Oral	Greenstone LLC	2014-10-27	Not Applicable
Sirolimus	Tablet	1 mg/1	Oral	Dr. Reddy’s Laboratories Limited	2014-10-27	Not Applicable
Sirolimus	Tablet, film coated	0.5 mg/1	Oral	American Health Packaging	2015-03-31	2020-04-30
Sirolimus	Solution	1 mg/1mL	Oral	Apotex Corp	2020-05-20	2025-03-31
Sirolimus	Tablet, film coated	2 mg/1	Oral	Glenmark Pharmaceuticals Inc., USA	2020-10-16	Not Applicable
Sirolimus	Tablet, film coated	0.5 mg/1	Oral	Zydus Pharmaceuticals (USA) Inc.	2014-01-15	Not Applicable
Sirolimus	Tablet	2 mg/1	Oral	Ascend Laboratories, LLC	2021-03-13	Not Applicable
Sirolimus	Tablet, sugar coated	1 mg/1	Oral	Greenstone LLC	2014-10-27	Not Applicable
Sirolimus	Tablet, film coated	1 mg/1	Oral	NorthStar Rx LLC	2021-10-18	Not Applicable
Sirolimus	Solution	1 mg/1mL	Oral	Amneal Pharmaceuticals NY LLC	2019-10-25	Not Applicable
Sirolimus	Tablet, film coated	1 mg/1	Oral	Zydus Pharmaceuticals (USA) Inc.	2014-01-07	2014-01-03
Sirolimus	Solution	1 mg/1mL	Oral	Vistapharm, Inc.	2019-01-28	Not Applicable
Sirolimus	Solution	1 mg/1mL	Oral	Torrent Pharmaceuticals Limited	2021-12-27	Not Applicable
Sirolimus	Tablet, film coated	1 mg/1	Oral	Glenmark Pharmaceuticals Inc., USA	2020-10-16	Not Applicable
Sirolimus	Tablet	1 mg/1	Oral	AvPAK	2018-04-23	Not Applicable
Sirolimus	Tablet	1 mg/1	Oral	Ascend Laboratories, LLC	2021-03-13	Not Applicable
Sirolimus	Tablet, film coated	0.5 mg/1	Oral	Cadila Healthcare Limited	2014-01-15	Not Applicable
Sirolimus	Tablet, film coated	0.5 mg/1	Oral	NorthStar Rx LLC	2021-10-18	Not Applicable
Sirolimus	Tablet, sugar coated	0.5 mg/1	Oral	Greenstone LLC	2014-01-07	Not Applicable
Sirolimus	Tablet, film coated	1 mg/1	Oral	Cadila Healthcare Limited	2014-01-07	2014-01-03

[beaker356]

FYI. Greenstone Pharmaceuticals was the generic house for Upjohn, which made Rapamune. When you buy sirolimus by Greenstone you get brand Rapamune. FYI: both Upjohn and Greenstone are now owned by Pfizer. From an old pharmacist.

[RapAdmin]

@beaker356

FYI. Greenstone Pharmaceuticals was the generic house for Upjohn, which made Rapamune

Good to know. Thanks!

Greenstone launches authorized generic of Pfizer's Rapamune

[Jay]

Maybe I’ve got the wrong company, but here is a reddit report that gives me reason to question TrueLIFE Research. The thread is 7 years old and possibly about a different company, but still of concern to me. I also could not find the location of the company from their website. If this information is not about TrueLIFE Research, let me know.

r/Nootropics - TLR (True Life Research) Product Testing Results

[Nick_Westgate]

Any update on TLR? Has anyone tested rapa from them? Thanks!

[RapAdmin]

I have never heard of this company and have no opinion on them.

But given that we have a long list of online pharmacies in our FAQ and known list of large pharmaceutical companies manufacturing rapamycin, why would anyone bother with the risk of some small unknown supplier with a questionable history?

[DyingSucks]

Well, because you can buy 1 Gram of Rapamycin for $338!

“IF” it’s legit, it’s quite a good price and an American company, whereas all other such options I’ve seen for powder have been Chinese (hard pass). If pure, it would certainly make sense for at least the hair, skin and dental experiments we’re discussing on the board. A lot more palatable to do the left vs right side of the body skin experiment at this price.

I’ve read on the forum that the Zydus and Biocon tablets have been tested. How much would it cost to test this product?

[RapAdmin]

Yes - price is good. Someone may want to call them and ask them if this rapamycin / sirolimus is actually manufactured in China or the USA. I suspect its China and just imported here.

Absolutely - fine for topical / hair / skin products.

@Mac , I think mentioned he found a lab in Canada that would do some purity testing I think for around $200. It might make sense for a couple people to go in together and buy a few grams of the powder and test it. Or perhaps thats not needed if its mfg. in US and sold by a US company.

[DyingSucks]

I feel kinda stupid that it didn’t occur to me that they might/probably just import crap from China. I’ll inquire and post back what they say.

Frankly, I wouldn’t even put anything from China on my skin. I’ve spent a little time in China and have a friend who lived there for 2 years. The prevailing business ethos is: If there’s a profit to be made, I dgaf as long as someone buys. Not universal, but enough.

And this is the same industry that ships fentanyl to Mexico for the US market knowing its killing >100,000 Americans per year. They dgaf.

[RapAdmin]

@DyingSucks

The prevailing business ethos is: If there’s a profit to be made, I dgaf

Precisely… 100% my experience also.

[José]

@DyingSucks

Well, because you can buy 1 “Gram of Rapamycin for $338!”

Which Company?

Do they supply an assay?

[RapAdmin]

See:

rapamycin-cas-no-53123-88-9

[MAC]

I asked where is it manufactured.

“It’s manufactured by the premiere manufacturer of this class of compounds”.

The avoidance to the country of origin question, the stereoisomer levels, and the price screams China.

[desertshores]

So, that is for “pre-order”? Suggesting that they don’t actually have any.
Can’t find any country of origin or third-party testing.
Looks pretty sketchy

[RapAdmin]

Yes… Typically the case.

about 80 percent of the active pharmaceutical ingredients (APIs) used to make drugs in the United States are said to come from China and other countries like India.

U.S. Dependence on Pharmaceutical Products From China

[CTStan]

I requested and received a COA from a Chinese company that gave me a good price on powder. I reviewed the certificate and found that everything appeared good…except they overlooked changing the molecular weight when they altered the COA of another product that had the same appearance and was much cheaper.