#1

Methods

We evaluated the effects of NIC on frailty, physical function, and metabolic function using Caenorhabditis elegans (C. elegans) and aging mouse models. NIC effectiveness was assessed using behavioral experiments, histological analysis, and molecular biological analysis.

Results

We identified NIC as a compound that enhanced exercise capacity and metabolism, thereby alleviating frailty. Briefly, NIC extended the lifespan and improved frailty-related phenotypes in C. elegans, and effectively ameliorated frailty in aging mice, particularly in muscle aging. Additionally, NIC treatment suppressed the muscle atrophy-related ubiquitin–proteasome system induced by mammalian target of rapamycin complex 1 (mTORC1) hyperactivation, while enhancing autophagic flux, another aspect of proteostasis. Furthermore, mRNA-seq analysis revealed that NIC improved metabolism-related functions.

Conclusion

Collectively, these findings suggest that NIC is a promising novel candidate for the prevention of frailty.

Open Access Paper:

https://www.sciencedirect.com/science/article/pii/S2090123225002711

4 Likes
#2

Somebody smarter than me explain how a substance causes this:
“enhanced exercise capacity and metabolism”

By doing this:
“It works by blocking glucose uptake and oxidative phosphorylation”

1 Like
#3

Interesting the similarity with rapa. Both, niclosamide and rapamycin, inhibits the mTORC1 while enhancing autophagic flux in C. elegant and mice.

1 Like
#4

I was wondering if I could reply to you due my chronic ignorance:)
They found that niclosamide (anthelmintic medication) was capable to enhance the process of autophagy in muscles (while suppressing mTORC1) in vivo.
Past studies had shown that autophagy is diminished in frailty. Reduced autophagy causes impaired cellular function.
Autophagy, metabolism (mTOR, AMPK) and cellular function work hand in hand. Interconnected processes that maintain cellular function and homeostase.

1 Like
#5

I like your explanation better than their’s. It just doesn’t make sense to me that blocking fuel intake and blocking the primary energy metabolism could improve exercise capacity.

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#8

You are aware it is not available in the US as medical packaged item. Remove from market as it was not profitable by Bayer.

You can get it compound with a prescription in the US.

Available outside of the US for human use(medical)or as a research compound in the US.

1 Like
#9

“The challenge of repurposing niclosamide: Considering pharmacokinetic parameters, routes of administration, and drug metabolism”

https://www.sciencedirect.com/science/article/abs/pii/S1773224723000394