#143

The observations here as well as my own experience of omega 3A supplements makes me think that there is a subpopulation that respond with mood changes when supplementing with omega 3. In this paper there is a signal in that direction.

Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial - PubMed Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial - PubMed

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#144

I think you are saying that you do not get fear/anxiety from algae oil?

Which brand does Johnson take?

I mostly take IWI brand EPA only … I do take a dha/epa mix 1 or 2 x per week to emulate one who eats fish.

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#145

@CronosTempi You can slice and dice like no other :slight_smile:

You are a wordsmith extraordinaire!!

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#146

No, that one gave me anxiety as well. I edited my post.

Bryan Johnson takes Vegetology.

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#147

Just published: Association between DHA and depression: results from the NHANES 2011–2014 and a bidirectional Mendelian randomization analysis 2025

They found a protective effect:

This NHANES analysis has shown that DHA is associated with depression in American adults (OR = 0.996, 95% CI 0.993–0.999, P = 0.014). Bidirectional MR analysis demonstrated a significant causal relationship between DHA and depression in the European population (OR = 0.9, 95% CI 0.84–0.97, P = 0.006).

So does it change everything? Not sure:

  • It’s a weak team from the unknown “Chongqing Mental Health Center”, not even a university and they don’t seem to publish: Chongqing Mental Health Center | Institution outputs | Nature Index
  • They say that “Three multivariate regression models were constructed: crude, unadjusted; model 1, adjusted for age, gender, and race/ethnicity; model 2, adjusted for age, gender, race/ethnicity, education, RIP, BMI, smoking, and alcohol consumption.” So obviously we want the results of model 2, but in the abstract, they only give the result of model 1 (“OR = 0.996”), whereas in the text they note “It is important to note, though, that the association between the two was not statistically significant in Model 2, but the trend remained. For this result, similar to the study by Wang et al. [22], they also observed that the association between plasma DHA and depression did not persist after controlling for all potential confounding factors.” The model 2 found OR = 0.998, 95% CI 0.995–1.001, P= 0.11) That’s not professional. It makes me doubt the rest of the paper…
  • They don’t cite the VITAL-DEP trial that showed increased depression with EPA + DHA but cite other small trials that align with their conclusion that DPA is protective: shows a lack of intellectual honesty
  • A 2024 MR by a better research team didn’t find that result: Omega-3 fatty acids and major depression: a Mendelian randomization study 2024. Did the Chinese do the MR correctly? :man_shrugging:
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#148

Half of Chinese papers are fake. So if one comes out against the consensus, I’d say it’s in the rubbish 50%.

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