Ora Biomedical lança crowdfunding do Million Molecule Challenge

[jakexb]

Um esforço importante para encontrar o próximo medicamento para longevidade semelhante à rapamicina:

A Ora Biomedical desenvolveu uma nova tecnologia revolucionária que combina robótica com inteligência artificial para automatizar análises de expectativa de vida e saúde no nematóide Caenorhabditis elegans. Esta tecnologia permite-nos avaliar quantitativamente o impacto das intervenções de longevidade numa escala três ordens de grandeza superior à que é possível hoje. Nosso objetivo: avaliar 1,000,000 de intervenções de longevidade em 5 anos. Esse é o Desafio do Milhão de Moléculas.

Ao patrocinar intervenções aqui, você estará contribuindo diretamente para a descoberta da ciência da longevidade. Você é coproprietário dos dados e pode até escolher as intervenções. Intervenções únicas, combinações de intervenções (adoramos combinações!), até mesmo bibliotecas inteiras específicas. Está tudo nas tuas mãos. Competir contra amigos e colegas para ver como você se sai nas tabelas de classificação de longevidade. E embora você sempre possa optar por não participar, esperamos que considere permitir que sua intervenção patrocinada seja depositada em um banco de dados de longevidade disponível publicamente, que será disponibilizado ao mundo, sem restrições, catalisando a ciência da longevidade para o futuro.

Como é que isso funciona?

É simples. A Ora Biomedical criou um conjunto de intervenções que você pode escolher para patrocinar. Basta selecionar as intervenções que deseja patrocinar no menu suspenso ou você pode optar por deixar o destino decidir e usar nossa Máquina de Intervenção Aleatória para selecionar suas intervenções para você. O custo de patrocinar uma intervenção é de US$ 100.

Fonte: Postagem da Ora Biomedical no Twitter

Saiba mais sobre as oportunidades de patrocínio do CrowdFunding:

https://orabiomedical.com/sponsor-mmc/

Vídeo sobre a iniciativa: https://www.youtube.com/watch?v=kEzRU_jTKl8

[Joseph_Lavelle]

Ooooh. We should pool our money and sponsor a test. What shall we test?

[RapAdmin]

More details on this program, who is going to fund some interventions? I know of at least one person…

Want to have an impact in longevity? Help support the Million Molecule Challenge!

[Bicep]

Wow, I can’t believe they had Pentadecanoic Acid Supplement on the list.
They must have tried everything on the list already. Not that many things on there.

[Neo]

Went through the process for (dimethyl fumarate) - very simple and quick.

[John_Hemming]

Interestingly they have Citric Acid on the list, but none of Magnesium, Sodium, Potassium or Calcium citrate. My view about Citric Acid is that the acid aspect is harmful in the volume of citrate that you need to take to have a good effect. They also don’t have melatonin on the list.

[Krister_Kauppi]

@Bicep and @John_Hemming I have talked to the people on the Ora Biomedical and their current library consist of 2350 FDA approved drugs and some small number of natural compounds. They will expand they library with more drugs and natural compounds. But every such step is an investment.

One investment we are doing in the “Rapamycin Longevity Lab” initiative is to add 200 mTOR inhibitors to the library. You can read more about this initiative here.

Prelaunch of the Rapamycin Longevity Lab and the use of the wormbot

I get really frustrated that things go so slow forward in the rapamycin longevity field so it’s time to speed things up. This is why I now launch the Rapamycin Longevity Lab so that we together, people and organizations, can start moving things forward. (The real official launch of the lab is on Saturday) The Rapamycin Longevity Lab has partnered up with Ora Biomedical and we will use their groundbreaking wormbot to do the following two revolutionary projects to start moving things forward. Longevity Wormbot Program (LOOP) This first revolutionary project is about setting up a yearly next level ITP but instead of doing it on mice we do it on roundworms. We can do around 4500 experiments for the same price as one experiment for the classic ITP. This opens up enormous opportunities to start screening in a way we never were able to do before in the longevity field. In the first LOOP we use Rapamycin and combine it with around 2350 FDA approved drugs to find what combinations have syn…

[John_Hemming]

I buy citrate in bulk (25kg) (some hydrous some anhydrous) and it costs about GBP 15 per kilo. Obviously smaller quantities would be more expensive per kilo.

In the end, however, I have my own small biohacking trial that is gradually increasing in size so I am not particularly bothered what effect it has on worms. I would pay them a reasonable amount for a test, however.

Citrate is solidly GRAS. When people have a blood transfusion for example, it tends to be infused with sodium citrate which is also used to make Nachos. (the formula is Na₃C₆H₅O₇) Given my experience with eating insane quantities of citrate I wonder sometimes if one of the benefits people get from a blood transfusion arises from the additional gene expression from the citrate.

I see no merit, however, in me giving them funds to test anything else just because the test is cheaper.

They do have C₆H₈O₇ on their list (Citric acid, Citrate plus three separate protons) the main acid in Lemon Juice (and Lime Juice/Grapefruit Juice).

However, I think eating a lot of acid would be something I would not wish to try. Cells deacetylate the histone to increase the pH which would be a really bad thing.

[Krister_Kauppi]

What biohacking trial is it that you refer to? Is it the MN=1 that we talked about?

I don’t see any conflicts with that human trial and large screening in worms. As I see it the screening will open up totally new territories in the longevity field that we have not looked at yet. If we would for example get a really large combination effect of one FDA approved drug and Rapamycin then that combination would be very interesting to do a ITP on and see if the effects also exist there. This way we come step by step closer to human trials and move the field forward.

Curious question, do you see very little value in doing large scale experiments in a cost-effective way where Rapamycin is combined with FDA approved drugs and natural compounds? What would be needed to increase the perceived value for you?

[John_Hemming]

No its not the MN=1 trials that we will be doing via rapamycin news. It could be one of those trials, but as it is my own personal hypothesis I think it best that we start with something else.

I have a small group of people - mainly friends and family - that are following the protocol to improve gene transcription (and translation). I don’t mind if more people join that, but what I have suggested as the first MN=1 trial relates to Rapamycin.

The reason why I personally am not particularly interested in testing lots and lots of molecules is I have a clear mechanistic hypothesis (transcription/translation) where it is clear what you can do that is synergistic and it produces good results. Hence I personally want to focus on this. Rapamycin is part of this because of its effects in mitochondria.

Because we are doing that testing in human beings, therefore, there is a lesser, but non zero merit in having some worm testing.

In the absence of a realistic practical hypothesis the approach of testing very large numbers of molecules has merit and I am not saying to anyone they should not do that. However, my situation is different.

Because I don’t need any funding (I am self funded) and I already have people in my biohacking trial I am not really beating the drum for my protocol. What I need to do is to get on with the testing. It is quite complicated because it is multidimensional and has two main pathways. Hence in transcription there are issues about levels of acetyl-CoA, RNA, HDAC inhibitors and also I think serum Lithium. In translation it is all about mitochondrial efficiency, but a lot affects that. Hence I am testing out lots of different approaches in terms of dosing, timing and combinations.

In the mean time I have to get on with life as well. I am a tech entrpreneur and investor as well as a musician and I have five children - only one now under the age of 18. Hence I am quite busy.

[medaura]

From their materials:

And by “better” we mean larger effects on lifespan and healthspan – because that’s what we care about. How can we be so certain? Because just from a small pilot screen of a few mTOR inhibitors, Ora has already identified one that works better than rapamycin.

What would that be?

[jakexb]

Just sponsored one. Hope they get tons of people funding this!

[RapAdmin]

I find it rather amusing that this week Matt and Brad Stanfield chose colchicine as the medicine to test in the wormbot.

Given our recent conversation about this drug:

Statin use inhibits vitamin K2

This too… regarding Colchicine… Its a serious and rather scary drug in today’s news: A poison specialist and former medical resident at Mayo Clinic in Minnesota is charged with fatally poisoning his wife, a 32-year-old pharmacist who died days after she went to a hospital in August with stomach distress. Authorities say Connor Bowman, 30, tried to stop the autopsy on his wife, Betty Bowman - arguing she should be cremated immediately and claiming she had a rare illness, which hospital tests did not confirm. The medical examiner’s office halted the order for cremation, citing suspicious circumstances, according to a criminal complaint, and an autopsy showed Betty Bowman died from toxic effects of colchicine, a medicine used to treat gout.

Of course, more broadly it looks like an interesting drug: Gout Medication Colchicine Reduce Myocardial Infarction? 2019 N Engl Journal

[DeStrider]

I think Rapamycin + Taurine is going to be a winning combination. Let’s see if I’m right.

Seems they’ve raised about $860,000 through this challenge in 2 weeks. Honestly, this is the way to raise money for longevity research.

I’ve supported the Million Molecule Challenge! https://orabiomedical.com/product/double-compound-intervention/… #millionmoleculechallenge via

@OraBiomedical

How do we find the leader board?

[DeStrider]

Based on how toxic colchicine can be, I think that wasn’t the best choice by Dr. Brad. But, why not give it a go anyways…

[jjrap1]

I supported them too. Not a biologist so I let them choose; would be interested in seeing what I (and others) have ended up selecting.

[jakexb]

Longevity is a perfect match for this strategy. We know that the basic pathways are conserved across evolution all the way back to really simple organisms. And it’s pretty easy to tell whether a worm is living or dead. So you have an automate-able endpoint and a simple model organism with a short natural lifespan and you can just go to town. Really genius stuff.

[Curious]

Did you bet on Rapamycin + Taurine? just to make sure I understand the competition

[DeStrider]

I did. I paid $200 to do the combination of the two chemicals.

Frankly, I also want to know the answer personally as I am taking both compounds daily. It’s about as expensive as a blood test, and in some ways more informative. Rapamycin and Taurine are the two supplements I take the most of. I want to know if they work well together.

I recommend others do the same if you are taking a few supplements together.

[jjrap1]

One question I had: what happens when multiple people choose the same protocol? For instance, I can’t believe that the rapa/taurine combo hasn’t been submitted multiple times already??? What then? How/where can one find out what protocols have been selected to be tested?