This is fairly common with brain oriented drugs and peptides.
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Tim
#759
Also causes pedema and severe facial flushing. The flushing fades after a few hours, but the pedema, which interferes with running, endures for 24-36. Not a pleasant experience. I will titrate downward to find the lowest but still effective dose.
I was under the impression that growth hormone was antithetical to longevity? CJC and Ipamorelin are growth hormone releasing hormone peptides.
Yes and very effective for that purpose.
As far as the “longevity” aspect, there are many fish to fry in that ocean 
hGH and IGF-1 are both good and bad - at the same time… so pick your poison as they say. Yes there are large population studies indicating high IGF-1 is not good. As well as studies that indicate it’s beneficial for cognition as we age, as is hGH.
What is the balance between the benefits and drawbacks? each individual must weight those for any intervention they decide to use.
When there is a perfect path to maximum health span I’d use that algorithm. Maybe someday in the near future there will be an AI for that. I’d love to upload my DNA sequence, all my blood work and tests and have a better idea of how far I can push the limits of personal experimentation. In the meantime I have to be my own personal AI
With respect to “longevity” there is no way to extend human lifespan beyond 120, I’m not terribly worried about trying to do something that is impossible so I focus on things that may increase my health span.
Having a robust and effective immune system as we age is;
- important?
- not important?
And that is why I like the idea of the TRIIM protocol, which requires hGH. hGH has been studied for this effect for over 20 years now. Thymic involution degrades the effectiveness of our immune system. hGH does reverse that.
So far, from what I’ve seen in my blood work, my immune system is excellent and for the past 18 months I’ve not had a cold or the flu or any sickness like that. And I get exposed, on a regular basis to my “sick” grand kids, sick work mates, sick friends. All of whom I can’t avoid.
Overall it’s pretty awesome being as healthy as I’m fortunate to be, same for my wife.
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What makes going beyond 120 impossible to you given we don’t know what the future holds?
TRIIM protocol sounds interesting I have heard about this one. I’ve been looking into thymus regeneration myself. Tried out some TB500, is that any good for this?
The elastin problem is what limits the max human life span to 120. It is a “hard stop” and today there is no solution to that problem and there will not be a solution in my life time.
It’s extremely complex but well researched and very well understood as to what elastin is and what it does. The fix on the other hand is 30+ years away, IMHO.
It’s actually more difficult that solving “cancer”, when do you see cancer being solved? sure treated but solved??? There are a few vaccines for specific cancers that are tremendously successful but they don’t “solve” all cancers.
Look up elastin on the forum, I’ve posted on this quite a bit
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TB500 is not going to restore the thymus.
The thymus generates 3 Thymulin hormones
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/thymus-hormone
Also there is a lot of confusion on what TB500 is. It’s actually a sub set of Thymosin Beta-4. There are 3 “versions” avalable. I’ve posted an extensive review of that in this thread.
Depending on the source, you might not be getting what you think you are getting
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I had been using Gonarorelin and after a 5 months there was a measurable increase in my testosterone. A month ago I switched to Kisspeptin 10 to check that one out. No ill effects so I decided to combine those 2 in one vial (I will take this 2 times per day, morning and night) for 6 weeks and a break of 1 week and go again.
They both provide a boost in test through different pathways.
https://www.differencebetween.com/what-is-the-difference-between-kisspeptin-10-and-gonadorelin/
I came up with a “catchy” name for this combo LoL!
KGB (Kis+Gon+B@lls)
I know, kinda crude but it made the wife laugh Since the doses are low, it’s quite cost effective.
I’m looking forward to my next test - test
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Maybe you’ve answered this elsewhere, but have you tried this peptide? I’ve heard about it, but I didn’t connect it to Stealth Bio. I just know it as SS 31.
I have not tried it yet and it’s on the list for my next order. In about a month I should have it in.
I have used MOTS-c, a mitochondrial “derived” peptide. Did not notice a big difference but I may have had my dose too low and timing may be more important than I thought.
Thanks Steve. I was very close to using Mots C about 5 years ago, and actually invested in Nir Barzilai’s company Cohbar - a great lesson here is that investing in Biotech gives you a high chance of losing all of your money.
Mots C is an interesting peptide and I think mitochondrial peptides are worth looking at. I decided against it at the time because I just didn’t have the means to measure any impact. It’s the reason I stopped peptides. I found it hard to measure. I just felt like I was literally shooting in the dark.
My renewed interest is because of Stealth bio getting through to the last round of the Xprize. Elampretide has a been approved by the FDA, which I was completely unaware of.
So I will probably see if I can run a small trial in the next few months, I’ve got access to more data now. At the very least I can probably get some directional data if I use it.
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Tim
#769
I have two or three, all related to running. Am I running faster and pain free? The answer is yes to both. By far the biggest answer, though, is that, at 77, I’m still running at all. Peptides, indisputably, keep me going.
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Some things are not easily measured but that doesn’t mean they don’t work or provide a benefit. Since our body makes about 7,000 peptides we know that without them we don’t exist, they are critical inter-system communicators, providing instructions on what happens in our body.
I’ve come to view them like dietary supplements and good food. As we age our body does not process things the way it used to, it does not produce important compounds we require to be healthy like it used to, and the internal comms become weaker.
So I supplement my declining peptides by adding them back in. Some are easily measured for benefit like I experienced with gonadorelin increasing my test.
My weight, as the miracle of GLP1-RA’s have changed my life.
My old injuries no longer being an issue as I age thanks to BPC 157 and TB 500/Goralitide. New injuries healing like I was a kid again. My immune system performance is more than good for a 69y/o thanks to our modified TRIIM protocol, TA-1 and LL 37 etc.
Endurance, strength, muscle tone, all improved with peptides.
Basically peptides are life, in my opinion.
As far as losing money in bio-tech, while that may be one good way to do that, I’ve experienced more than a few other ways LoL! I feel your pain
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I totally agree. I’ve been a heavy user of peptides, in fact, I just finished another round of BPC 157, for a tendon issue, but I can’t ‘prove’ that it’s useful. I’ve used BPC 157b andTB4, and I still can’t say categorically that they work. I still have my tendon issues. it’s not that I don’t believe that work, it’s just that at this point I’m more interested in what I can measure.
SS 31 is interesting because it’s been said to improve HRV, and that is something I can track.
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Jay
#772
Tim, it’s been a year since your post on Visoluten. Do you or your retina doc have any opinions on the effectiveness of Visoluten?
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Tendons are very slow to heal for a variety of reasons. Even after they appear to be healed and functional they are not fully healed.
This why I don’t do “rounds” or cycles of BPC+TB, I take them every morning for the past 20 months with a week off every 2 months. I take 500mcg of each
Also tendons heal better when there is hGH present, another reason I take Ipamorelin + CJC-1295 noDAC 5 nights a week for the past 20 months with a week or so off every couple months.
These 2 combinations have a lot of synergies related to healing. hGH and IGF-1 are very good at helping the body produce collagen which tendons need to heal. BPC activates hGH receptors in tendons, etc…
Tendons never repair to their previous condition, like all wounds. Deep cuts through muscle never heal to the same strength, wounds in skin never heal to the same strength. Tissue remodeling is very complex and anything that relies on elastin is not going to heal to the way it was previous to the injury.
Yes you can make tendons that have healed, stronger and larger with proper exercise and adequate nutrients present, but the injured area will never be as strong as it was before the injury.
I learned that from a couple of plastic surgeons I met when I was in the wound care industry in the 90’s
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Jay
#774
Steve_Combi, I plan to use CJC-1295 (no DAC) 100 mcg SC before bed and Ipamorelin: 200 mcg SC before bed for a duration of 4 to 8 weeks to help insure good bone repair after a broken femur. If you have time I’d like to know your sources for CJC-1295 and Ipamorelin, as well as the needles for SC injection. And, your method of proper dilution of CJC-1295 and Ipamorelin, plus sterilization methods. I’m asking for a lot, but I’m short on research time at this point. Thanks.
Happy to help but it may get long so lets do this by private messages. After it’s all sorted out we could do a synopsis to post so it’s only one post
Paul, if you haven’t watched this interview, it’s absolutely worth your time if you’re suffering from chronic tendon injury:
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Hey thanks. I haven’t seen this, much appreciated.
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