First of this week we started taking DSIP - delta sleep inducing peptide.
> Stage 3 NREM N3, slow-wave sleep (SWS), delta sleep, deep sleep 20 to 40 minutes
One of our clients has a watch that monitors sleep and his Delta sleep has increased from an average of 32 minutes to 51 minutes.
That was an interesting results so I’ve ordered 3 of those watches for myself, wife and 1 son 
The suggested dose range is 100mcg to 500mcg.
We started with a 200mcg dose for 2 nights, then 300mcg and then 400mcg. I don’t find any difference with a higher dose so last night went back down to 200mcg and seemed to get the same benefit.
We have both noticed a benefit. I typically get up once per night for a visit to the bat room usually around 4am. I’ve been finding that I don’t fully wake up during my excursion and I barely remember going back to sleep as it happens so quickly.
My wife is a light sleeper (mother of 4 - although our youngest is now 41 the old habits are hard to shake). She is noticing a similar effect, any time she wakes she finds she is back to sleep without any effort.
This is not at all like a “sleeping pill”, theoretically it only affects the duration of Delta sleep. A very important part of the sleep cycle. Neither of us have felt “groggy” in the morning but I do feel more rested. I’ve been dealing with chronic pain from a sciatic issue for 2 moths now and that was having a negative impact on my typical “I sleep like a stone” thing.
Now I’m back sleeping like a stone, maybe even better than that. The pain is still there but does not seem to have the same effect on my sleep.
I forgot to mention this one. Since losing 55lb 2 years ago, my hands have been cold almost all the time. Yesterday evening I noticed they were not cold and they haven’t been cold since I started DSIP. Granted it’s a lot warmer but my hands were cold all the time, not just when I was out doors but at work, at home, all the time.
May have a direct or indirect effect on body temperature and alleviating hypothermia.[21][22][23]
Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide that was first isolated from rabbit brain in 1977. It is known for its ability to promote sleep, particularly characterized by an increase in the delta rhythm of the EEG (electroencephalogram), which is associated with slow-wave sleep. DSIP is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
Here’s a more detailed look at DSIP:
Key Properties and Effects:
DSIP is known to induce sleep, particularly slow-wave sleep, in various animal models, including rabbits, mice, rats, and cats.
When infused into the brain, DSIP can reduce motor activity in rabbits.
DSIP concentrations in the brain and plasma exhibit a diurnal variation, with lower levels in the morning and higher levels in the afternoon.
- Modulates hormone secretion:
DSIP may play a role in regulating the release of hormones like growth hormone and prolactin.
- Potential therapeutic uses:
Studies have explored DSIP’s potential in treating insomnia, pain, and withdrawal symptoms, though results have been inconsistent.
- Possible links to other conditions:
DSIP-like immunoreactivity has been studied in relation to major depressive disorder, Cushing’s syndrome, and Alzheimer’s disease.
Mechanism of Action:
- Hypothalamus and brainstem:
DSIP is synthesized in the hypothalamus and targets multiple sites, including the brainstem.
DSIP is believed to influence the hypothalamus-pituitary-adrenal (HPA) axis, which is involved in stress response.
- Modulation of neurotransmitters:
DSIP may modulate neurotransmitter systems, potentially impacting sleep and other functions.
- Potential role in other pathways:
DSIP may also be involved in pathways like the MAPK and PI3K/AKT pathways, as well as interacting with the glucocorticoid-induced leucine zipper (GILZ).
Current Research:
While DSIP has been studied for many years, its precise role in sleep regulation and other physiological processes is still not fully understood.
Studies on DSIP’s effects on sleep have produced somewhat inconsistent results, and further research is needed to clarify its role.
- Potential for new treatments:
Despite the inconsistencies, DSIP’s potential in treating sleep disorders and other conditions continues to be explored.
In summary, Delta Sleep-Inducing Peptide is a neuropeptide that plays a role in regulating sleep and potentially other physiological processes. While its exact mechanisms and clinical applications are still under investigation, it remains a focus of research in the fields of sleep, neurobiology, and potential therapeutic interventions.
