With respect to TA-1 (thymosin alpha-1). I have used it and felt that it makes a difference. The trick to that peptide is you must only have the doses in a vial that you plan to use in 2 to 7 days. Dosing 1 vial within 5 days would be best. Some protocols show it being used every day for months for specific conditions.
Once it’s reconstituted the refrigerated shelf life is about 2 to 7 days at 4C (typical refrigerator temp)
As a powder it is shelf stable for 3 weeks at up to 40C. So shipping is not an issue.
As a powder 5 months stable at 4C and up to one year at -18C (we keep it at -21C)
TA-1 is very safe and the dose indicated 1.6mg is what is recommended by the mfg’s of Zadaxin (brand name for TA-1)
It is a very safe peptide to use and in some cases up to 16mg per daily dose have been used.
Here is an example of dosing and vial size that works;
1.6mg per daily dose x 3 per week = 4.8mg per vial – I’d suggest 5mg per vial (1.67mg per dose)
1 month would require 4 vials = 20mg
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Our body is a significant peptide synthesizer. It makes about 7,000 different peptides.
Fundamentally peptides are instruction sheets. They are used to communicate from one system to another.
When you eat and the glucose level rises in your blood, your system produces (among other things) Insulin. Insulin is a peptide based hormone (there are 4 types of hormones). This instruction sheet then tells specific cells what to do with the glucose.
Only cells with the insulin receptor respond to this instruction set.
Not every cell has every receptor for every peptide.
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I think improving transcription has an immediate effect on peptide production. Hence i think it is a good tool for improving metabolic homeostasis.
Tim
#681
Good to know, Steve. Thanks.
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Ulf
#682
Restoring my lymphocytes took 1,67 mg daily for 3 days, done in three rounds with a week to ten days between each.
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Tim
#683
Everychem gets some bad reviews. Could be fake reviews posted by competitors. Who knows? Gets good reviews on reddit. Are you disillusioned with your Chinese sources?
https://www.scamdoc.com/view/1322621
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“Company X gets good reviews and bad reviews.” Thanks for that insightful analysis?
My 5 Chinese sources have never let me down, but I haven’t seen TAK-653 and bromantane from China.
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cl-user
#685
Here is a comparison of 31 gauge needles from BD syringes (top) and Easy Touch syringes (bottom)
Rather similar but the BD have a bevel that makes the tip less sharp. Thanks to @Steve_Combi for pointing me to the Easy Touch ones. I have mostly no bruising with them.
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Beth
#686
This is great, thanks. I give my CKD cats sub q fluids and have learned from the pros that needles are not created equal… some are more hollow for faster flow (not important for an injection) and indeed, some brands are sharper.
Where do you get yours? I was advised never to buy on amazon due to many fakes being on there.
cl-user
#687
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Beth
#688
Thx! I just received an order of other items from them yesterday!
Tim
#689
What about 1/4 or 5/16 insulin needles?
cl-user
#690
These are 5/16 31G insulin needles
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I’m about to start an experiment with LL 37
Our daughter (51y/o) has ischemic bladder due to recurring UTI’s that don’t resolve. Or UTI’s due to ischemia, not sure about the chicken and egg part of this one. So I got some IL 37 in today and she will start on Monday or as soon as I’ve sorted out dosing. If anyone here has any experience with this peptide, I’m all ears! (or eyes 
)
LL-37, the master antimicrobial peptide, its multifaceted role from combating infections to cancer immunity
https://www.sciencedirect.com/science/article/abs/pii/S0924857924003145b
One of the antibiotics she was prescribed 5 years ago caused her to be “floxed”
We are hoping for relief for both or even one of these conditions. She is just finishing up a 4 week TA-1 routine but no great improvement yet.
edited to remove mis-leading info on IL37 and added more info on LL 37
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Bicep
#692
I’m confused about whether you’re looking at the peptide LL37 or interleukin IL37. It sounds like the latter. But LL37 is a great one and antimicrobial, made by many cells in the body. I’m curious how it comes out if you can buy that stuff. I’m interested. IL 37, I have no idea if this is a peptide.
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What I have is LL 37 peptide
My post on this is way off base LoL! for some reason I got the 2 mixed up. I’ll edit that post to clarify that.
I checked with my supplier and they don’t have IL37 but they do have an interesting selection of anti-virals.
Ludovic
#694
I came across this very interesting article about the peptide Thymosin beta-4 and the heart. I plan to use this peptide the day after 3 hour long trail runs I do every 2 weeks because i have genetic hypertrophic cardiomyopathy;
https://www.sciencedirect.com/science/article/pii/S1567576923000644#s0040
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There are 3 versions available;
TB500 (frag 1-4)
TB500 (frag 17-23)
TB500 (Full 43)
Frag = fragment, this is commonly done with peptides, to isolate a portion of the full peptide and use fragments for specific functions. I’ve been taking TB500 (frag 1-4) every morning (evry 2 months I take a week off) for about 15 months, in combination with BPC-157
The full version is the complete peptide of TB-4, not commonly available
Most common is TB500 (frag 1-4) with (frag 11-23) second in availability.
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Davin8r
#696
Hey Steve, everything I’ve read says the opposite – that TB4 is the one universally available and the “real” TB500 (the frag) is nearly impossible to find. Are you sure you’ve got that right?
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I’m impressed with LL 37, it has helped our daughter in a very short period of time, and she has been doing a UTI test every couple of days and seeing positive results but…
It’s not fully resolved yet and seems to be 2 steps forward and 1 back for her. Probably due to being on various antibiotics 6 to 7 times a year for the past 8 years and most likely hosting a variety of resistant pathogens. Once we see where this goes I’ll post the test results.
For me, I’ve been fighting a little thing for nearly 2 years that has been “chronic” it presents for 4 to 5 days a week, rarely more than 3 days without being present. Since I started LL 37 I’ve been free of this thing for 10 days now. Super happy with that result.
My reason for getting this one is is that it is anti-microbial, anti-viral and anti-fungal. Since most infectious pathogens modify our immune system to be able to “hide”, we can become more susceptible to that pathogen, Some of these like EBV are in us forever. with 90% of humans being infected with this one.
My thought process was to, hopefully, clear out any residual pathogens in the hopes that my immune system would become more robust.
Many of these residual pathogens and the modifications they make are root causes of various disease and conditions.
A study published in Nature Genetics details similar clusters suggesting that EBV also plays a role in six other diseases: multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis, and celiac disease
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