#1

FWIW Review …

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#2

Have been taking Turmeric with added Piperine for some time.

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#3

I avoid piperine. I take too many things that piperine could increase the levels of, so I think it’s just best for me to not have to deal with it.

#4

Everything I take is in small doses and taken with intervals, so if something gets increased by Piperine it’ll be OK.

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#5

Interesting research. Thank you for posting. I have been taking up to the recommended limit for years as an assimilative aid but never considered it for its standalone properties. In fact, Consumer Labs warns you to limit your dose.

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#6

A decent and I think accurate summation on Piperine in relation to ASCVD.

Piperine

Piperine, an alkaloid found in black pepper, has diverse pharmacological effects including bioavailability enhancement, anti-inflammatory, antioxidant, and lipid-modifying properties.

Mechanisms Potentially Reducing ASCVD Risk:

  1. Lipid Metabolism:
  • Piperine has been reported to lower serum triglycerides, LDL-C, and total cholesterol in animal studies. It influences enzymes involved in lipid metabolism and may reduce cholesterol synthesis via inhibition of HMG-CoA reductase, an enzyme targeted by statins for ASCVD prevention.
  1. Anti-inflammatory Action:
  • Piperine suppresses pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, and modulates signaling pathways like NF-κB and PPARs. These inflammatory mediators are key players in the progression of atherosclerosis.
  1. Antioxidant Effects:
  • Piperine has shown free radical scavenging activity, reducing oxidative damage and preventing LDL oxidation, a key step in atherogenesis.
  1. Endothelial Function:
  • Piperine has shown some promise in improving endothelial function, which is often impaired in ASCVD. Endothelial dysfunction is a precursor to atherosclerotic plaque formation and contributes to vascular inflammation.
  1. Insulin Sensitivity:
  • Piperine may also improve insulin sensitivity, an important factor in reducing ASCVD risk, particularly in individuals with metabolic syndrome or diabetes.
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