#1

Seeking thoughts from the excellent hive mind here regarding my persistent plantar fasciitis that refuses to respond to all the conventional treatment recommendations. (Neither being on weekly Rapa or not taking it has made no difference at all).

I’m thinking my next step might be going for PRP, but reading about all the postings here on peptides I thought BPC-157 might also sort it out (view corroborated by Perplxity.ai) but then I wondered if instead of an injection in the heal, Transcutol would work as a delivery method (that one Perplexity couldn’t answer).

Any thoughts from anyone on this? Will/could it work?

Also, if anyone in UK uses BPC-157, do you have a reliable source?

#2

I would mix DMSO about 90% solution with 10% distilled water. Spray it on liberally. On your foot it probably won’t even be uncomfortable. If it is the itching will go away in about 15 minutes. You’ll need to do it a few times, this is not magic. You can take a teaspoon in a glass of water orally, but it will make you stink.

Low cost, low risk and I think it will help.

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#3

What has this included? I had great response to steroid injunctions although required 3 injections.

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#4

Everything non-invasive, so I could try steroid injections as the next step.

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#5

My 1 year plantar fasciitis went away after taking very serious training of the feet. I’m now obsessed with muscular feet and muscular calves.

I once stopped doing these tips, and I felt the fascitis slowly coming back:

  • While brushing your teeth, for the rest of your life, do it one legged and putting your feet in difficult positions.
  • Calf rises while stepping into a towel (check videos) with increasing load every 3-4 days (listen to your feet).
  • Same as previous but with knees bent. It targets a different part of the calf.
  • While at home, always go without shoes.
  • Buy wider shoes.

It’s called fasciitis as in inflamation but it isnt, you need to have feet like a hobbit.

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#6

I’ve been doing all this for best part of a year, all the possible foot and leg exercises one can do, I am barefoot inside and only wear Vivo Barefoot outside so I feel I’m at the end of the road as far as non-invasive therapy is concerned.

Several years ago I had a first bout of Plantar Fasciitis and managed to eradicate it with the exercises etc and have continued with them ever since. The weird thing about this time is I stepped on an overnight long haul flight with no sign of any foot issues and stepped off that same flight in excruciating pain. How that happened I have no idea. My first thought was that I’d stepped on something really sharp that had cut the skin, but there was nothing there.
Now almost a year on it just won’t get better and if I run or play table tennis then it makes it significantly worse.
Hence I now feel my body just needs that extra bit of help to properly heal.
Could be steroid or PRP injection but having read about people finding those injections really painful that’s why I wondered about the BPC-157 and could it possibly cross the skin if mixed with Transcutol.

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#7

Oh, that is crazy that a flight made things that bad. Best of lucks with your healing!

I don’t have experience with anabolic substances, so I can’t help you…. I can only say my knee didn’t like Corticosteroid injections.

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#8

What? It is inflammatory.

@RPS i had horrible symptoms for years and tried everything. I did steroids as a last resort.

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#9

I would give it a try, but from what I have read, the peptide chains are very fragile; even rough handling can cause some degradation, so Transcutol may not be the best solution.

Here is a take from one Ai site:

Query: “Would adding Transcutol diethylene glycol monoethyl ether) to the BPC-157 peptide in an attempt to apply BPC-157 externally to the heel to alleviate the effects of Plantar Fasciitis have any effect, or would the Transcutol break up the peptide molecular structure?”

Answer: "Adding Transcutol (diethylene glycol monoethyl ether) to the BPC-157 peptide for external application to the heel in an attempt to alleviate plantar fasciitis may have potential therapeutic effects, but there are important considerations regarding the stability and efficacy of the peptide.

Transcutol is known to enhance the skin penetration and permeation of various drugs by interacting with the stratum corneum lipids, increasing their disorder and fluidity, which facilitates the delivery of small molecules and some larger molecules through the skin.[1-2] However, the effect of Transcutol on the stability and molecular structure of peptides like BPC-157 is less clear.

BPC-157 has shown promising results in wound healing and tissue repair when applied topically in various formulations, including creams.[3-4] However, the stability of BPC-157 in the presence of Transcutol has not been specifically studied. Given that Transcutol can alter the lipid structure of the skin, it is possible that it could also affect the stability of the peptide.

Therefore, while Transcutol may enhance the penetration of BPC-157 through the skin, there is a risk that Transcutol could disrupt the peptide’s molecular structure, potentially reducing its therapeutic efficacy. Further research is needed to confirm the stability and effectiveness of BPC-157 when combined with Transcutol for topical application. It is advisable to consult with a healthcare provider or a specialist in pharmaceutical formulations before attempting such a combination."

One study used BPC-157 in a cream to treat burns on mice.

(50 microg of BPC 157 dissolved in 2 ml of distilled water was mixed with 50 g of commercial neutral cream (also used as local vehicle-control)), while silver sulfadiazine 1% cream was a standard agent acting locally.}

https://sci-hub.se/10.1016/s0305-4179(01)00055-9

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#10

Strongly suggest checking out PEMF. It really works and I have used it for carpel tunnel, tarsal tunnel, tennis elbow, you name it. Hard to believe, but it works. Only negative is you need to wear it and use it for several hours a day. But as an example, carpel tunnel can take months to resolve with splints, nsaids, etc ( forget surgery). PEMF=days. I use the devices from https://www.micro-pulse.com/ , the M1.

#11

I am using a PEMF coil every night but currently it appears to have no effect. Maybe after another couple of weeks it will have worked, but given so far nothing has changed that’s why I’m exploring new options.

#12

FWIW, I wore rocker shoes (highest in the middle) for a while. One of the suggestions was to not use ones feet (to give them time to recover) – aka, not walking, nope, not happening.

But there was advice to put pressure on the instep & also to not put weight on one’s heel, so I figured rocker shoes would do it. My heel quit hurting after a while, so maybe it did work.

#13

Not sure if you have tried this or not but l found a lot benefit from following the work of Keith Baar. Doing isometric loads through the injured tissues for 30 seconds every 2 minutes for 3 sets. Repeated every 6 to 8 hrs.
I have found it very effective for repetitive injuries but the difficulty is finding the correct isometric exercise.

#14

I had severe plantar fasciitis for about a year, walking in the morning and sleeping was terrible. I started taking Tirzepitde for weight loss and it all went away, I would imagine it was a direct effect of the anti-inflammatory benefits of Triz. I also take bpc-157/TB4 for healing my shoulder and I would guess there are similar benefits with it as well. I also, swear by wearing my Hokas as general foot care.

Here is a Reddit where dozens of people report the same effect of Triz on PF

https://www.reddit.com/r/Mounjaro/s/tnpMtpOD2J

#15

Thank you @Elizabeth_Kirby and @EenDwaze thats two new things for me to look into.
@Aerosmit , glad that worked for you but there is no way I want anything to suppress my appetite given my current weight and fat % metrics
Thank you @desertshores for pointing out that Transcutol could affect the structure of the peptide. I might try that suggestion of mixing with neutral skin cream.

#16

Re PEMF, what settings are you using. Might want to speak directly to Bob Denis at ICES. He is very open to giving some advice re settings. Are you stacking the coils over the point of pain?

#17

Yes, I am stacking the coils and have worked my way up to the maximum setting.
I do find some partial relief first thing in the morning, but usually by the evening it’s as bad as ever especially after a game of table tennis. Since 2 weeks ago I’ve stopped all table tennis (am still lifting as don’t want to lose strength and zone two on a bike isn’t detrimental at all for the foot) so I was hoping this would really give it a chance to heal, but unfortunately right now I just don’t feel any improvement and table tennis will resume in a weeks time.

Anyway, I’ll probably keep doing PEMF even if I go for an injection of one sort or another as it should help anyway.

#18

Could it be vascular obstruction? It came to mind bc it happened to you on a long flight.

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#19

That is what I originally thought so went to the hospital. They said no, it’s just plantar fasciitis which fits with the symptoms back then and today (and I was showing none of the symptoms of vascular obstruction in the legs or feet).

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#20

Have you had an xray to make it is not a fracture, stress or hairline vs plantar fascitis?