I am preparing a poster for the above. This makes reference to this forum and I would like to ensure, therefore, that people are content with the words that I use.
My abstract has been accepted and is:
Continuing experimentation in the world of independent research raises questions about Rapamycin, the role of menaquinones in mitochondrial function, whether Parkinsons Disease and ALS/MND should be considered diseases of aging, what the role of transitions, transversions and deletions are in terms of the effects of mtDNA damage on gene expression and whether follicular atresia should be considered as part of the aging process.
I have put a draft of the poster on my citrate website. I intend first finalising the draft and then cutting it down to the format of an A0 poster. However, having a draft ensures that this forum can comment on any aspects that people think should be changed.
https://citrate.science/2025poster/poster2025.html
I am also intending to publish an infographic from the poster of which I published an earlier version here yesterday, but this is the current version with mistakes corrected.
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You should update the text to mention that the highest dose (60uM) weâve done resulted in an increase in the size of the worms similar to the size increase in rotifers. This, in combination with no evidence of toxicity at these doses, indicates that similar lifespan effects may be possible at higher doses, and this is why higher doses are being explored.
The link to the IPAM page on Rapamycin News you should change it to the original post, right now youâve got it on a random comment on the post.
Additionally I am experimenting with IPAM myself. I have consumed it a few times but that isnât really my focus as I wonât get much useful data from that. I can get some useful data from creating a topical formulation as I am seeing some interesting results in skin anti-aging effects which I want to explore further.
If we get the higher dose results before the event comes out please update the poster.
I am going to update the image to mention this study was done in worms and add a bit more information:
I appreciate the mention.
Because there are no word limits on the website I can easily add to that. I would not myself say âDoses were too low to change lifespanâ as we donât know they will change lifespan at a higher dose.
I will, of course, update the website when the results are out and if the results are in sufficient time to be printed in the poster (which is about 2 weeks before the conference) then I will have them in the poster.
What I will do is wait for any other comments on this topic and then do a single set of modifications to the web post.
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Fair point. We will see what happens. But I think itâs still a true statement, if lifespan didnât meaningfully go up or down then the dose is too low. Everything will have an effect at some dosage level.
I have updated the poster quite a bit. Here are two photos
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